HYPERCHOLESTEROLEMIA

This early-phase study tests a single dose of VERVE-201, a gene-editing therapy, in 36 adults with high cholesterol and triglycerides that don't respond to standard treatments. The goal is to see if it is safe and to measure how it affects blood fat levels. Participants must not …

This study tests whether two food supplements, Cynacol and Metacol, can lower LDL (bad) cholesterol in people with mild high cholesterol. About 40 adults aged 35-70 with LDL levels between 115 and 190 mg/dL will take one supplement daily for 90 days. The goal is to see which supp…

This study will follow 3,000 Italian adults taking Inclisiran, a long-acting cholesterol-lowering injection, to see how consistently they take it and how much their LDL (bad) cholesterol drops. Researchers want to understand real-world adherence and effectiveness, not test a new …

This study tests whether starting cholesterol-lowering care in the emergency department can reduce heart risks for adults aged 40-75 who are at risk for heart disease but not yet on treatment. About 130 participants will receive a guideline-based program to lower their cholestero…

This study tests whether a church-based program led by community health workers can help Black adults in New Orleans lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 800 participants aged 40 and older with at least three heart risk fac…

This study compares the effects of corn oil and avocado oil on cholesterol in adults with mildly to moderately high non-HDL cholesterol. Over 54 participants will follow a controlled diet with each oil for 21 days, with a break in between. The goal is to see which oil better redu…

This study tests whether sharing genetic test results with Veterans who have high cholesterol can help them feel more confident about taking statins. Many Veterans avoid statins due to fear of side effects or doubts about benefits. By showing each person their unique genetic risk…

This study tests whether a time-saving, joint-friendly muscle stimulation technology (whole-body electromyostimulation) can lower resting blood pressure and improve other heart-related risk factors in people with mild high blood pressure and overweight. Researchers will compare t…

This study will track 5,000 people in Italy who are prescribed PCSK9 inhibitors for high cholesterol. Researchers want to see how consistently patients take their medication, how long they stay on it, and how much their cholesterol levels drop. The goal is to understand real-worl…

This study looks at people with lipid disorders—conditions where fats like cholesterol are too high or too low in the blood. Researchers want to learn how these fats cause diseases like hardening of the arteries. Up to 2,000 adults and children (ages 2 and up) will have their blo…

This study will follow 1,500 Italian adults taking bempedoic acid for high cholesterol to see how consistently they take the medication and how much their LDL cholesterol drops. Researchers will also track side effects. The goal is to understand how the drug works outside of cont…