HYPERCHOLESTEROLEMIA

This study tests whether a weekly dose of alirocumab (Praluent) is safe and effective for adults with high cholesterol. Alirocumab is already approved for use every two weeks, but this trial explores if giving it weekly works better. About 420 participants will receive different …

This study tests a new drug called SHR-1918 for people with high cholesterol that remains high even when taking statins and another type of cholesterol-lowering drug (PCSK9 inhibitors). About 126 adults will receive either SHR-1918 or a placebo to see if it safely lowers their LD…

This study compares two cholesterol-lowering strategies in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate-dose statin plus ezetimibe, the other gets a high-dose statin alone. The goal is to see if the combo is just as g…

This study looks at whether combining two different cholesterol-lowering drugs (inclisiran and alirocumab) works better than using either alone. About 60 adults with high heart risk who cannot take statins will be assigned to one of three groups. The goal is to see if the combo l…

This early-stage study tests a single dose of VERVE-201, a gene-editing therapy, in 36 adults with dangerously high cholesterol and triglycerides that don't respond to standard treatments. The treatment aims to permanently turn off a liver gene (ANGPTL3) to lower blood fats. The …

This study compares how corn oil and avocado oil affect cholesterol levels in people with mildly to moderately high non-HDL cholesterol. Over 54 participants will follow a controlled diet for 21 days with each oil, separated by a 21-day break. The goal is to see which oil improve…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent heart attacks and strokes in people at risk. About 130 adults aged 40-75 who are in the ER for possible heart issues will receive guideline-based care. The goal is to low…

This study will follow 3,000 adults in Italy who are already taking Inclisiran, a long-acting injection for high cholesterol. Researchers want to see how consistently patients take the medication and how much it lowers their LDL ("bad") cholesterol in everyday practice. The goal …

This study compares two food supplements, Cynacol and Metacol, to see which one lowers 'bad' LDL cholesterol better in people with mild high cholesterol. About 40 adults aged 35-70 with LDL levels between 115-190 mg/dL will take one supplement daily for 90 days. The goal is to fi…

This study aims to learn more about lipid disorders—conditions that affect fats like cholesterol in the blood. Researchers will observe up to 2,000 people with abnormal cholesterol levels to better understand how these disorders develop and how to diagnose them. Participants will…

This study will follow 1,500 Italian adults taking bempedoic acid for high cholesterol to see how consistently they take the medication and how well it lowers their cholesterol. Researchers will also check for side effects. The goal is to understand real-world use, not to test a …

This study is following 5,000 Italian patients who are taking PCSK9 inhibitor injections (Repatha or Praluent) for high cholesterol. Researchers want to see how consistently patients take their medication and how well it lowers their LDL cholesterol in real life, not just in a la…