Gene-Editing shot aims to slash cholesterol that drugs Can't touch
NCT ID NCT06451770
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This early-stage study tests a single dose of VERVE-201, a gene-editing therapy, in 36 adults with dangerously high cholesterol and triglycerides that don't respond to standard treatments. The treatment aims to permanently turn off a liver gene (ANGPTL3) to lower blood fats. The main goal is to check safety, but researchers will also measure how well it works.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Study Center
RECRUITINGClearwater, Florida, 33756, United States
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Clinical Study Center
RECRUITINGMiami Lakes, Florida, 33016, United States
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Clinical Study Center
RECRUITINGPort Orange, Florida, 32127, United States
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Clinical Study Center
RECRUITINGNew York, New York, 10029, United States
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Clinical Study Center
RECRUITINGAdelaide, Australia
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Clinical Study Center
RECRUITINGMelbourne, Australia
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Clinical Study Center
RECRUITINGChicoutimi, Canada
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Clinical Study Center
RECRUITINGMontreal, Canada
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Clinical Study Center
RECRUITINGToronto, Canada
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Clinical Study Center
RECRUITINGAmsterdam, Netherlands
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Clinical Study Center
RECRUITINGCape Town, South Africa
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Clinical Study Center
RECRUITINGJohannesburg, South Africa
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Clinical Study Center
RECRUITINGLiverpool, United Kingdom
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Clinical Study Center
RECRUITINGLondon, United Kingdom
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Clinical Study Center
RECRUITINGManchester, United Kingdom
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Clinical Study Center 2
RECRUITINGManchester, United Kingdom
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Other studies related to the condition(s) this trial covers.
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