HYPERTRIGLYCERIDEMIA

This phase 2 trial tests an injectable drug called ION775 in 72 adults with high or severely high triglycerides. The goal is to see if it safely lowers fasting triglyceride levels. Participants continue standard care while receiving the study drug.

This study tests a new medicine called SHR-1918 for people with high triglycerides, a type of blood fat that can raise heart risk. About 360 adults will get either the drug or a placebo for 48 weeks to see if it safely lowers fat levels. The goal is to control the condition, not …

This study tests the long-term safety and effectiveness of a drug called plozasiran in adults with very high triglycerides (a type of fat in the blood). About 869 people who completed earlier studies will receive injections every 3 months for 2 years. The goal is to see if the dr…

This early-stage trial tests a new CRISPR-based treatment called CTX310 for people with severe cholesterol and triglyceride problems that don't improve with standard therapies. The treatment uses a tiny fat bubble to deliver gene-editing tools that turn off a gene linked to high …

This Phase 2 trial tests whether the drug RBD5044 can safely lower high triglyceride levels in adults. About 40 Chinese participants with high triglycerides will receive either RBD5044 or a placebo twice over 84 days. The main goal is to see if RBD5044 reduces triglyceride levels…

This early-stage study tests a single dose of VERVE-201, a gene-editing therapy, in 36 adults with dangerously high cholesterol and triglycerides that don't respond to standard treatments. The treatment aims to permanently turn off a liver gene (ANGPTL3) to lower blood fats. The …

This study tests whether adding chia and pumpkin seeds to a standard healthy diet can lower triglyceride levels in people with hypertriglyceridemia. 375 adults with moderately high triglycerides will follow a balanced diet for 4 weeks, with half also eating seeds. The goal is to …

This study tests a new injection called JMT202 in 48 Chinese adults with very high triglycerides (a type of fat in the blood). The goal is to see if it is safe and can lower triglyceride levels. Participants will receive either the drug or a placebo over several doses, and resear…

This Phase 2 study tests whether the drug MAR001 can lower blood fat levels after a meal in adults with high triglycerides. Thirty participants will receive either MAR001 or a placebo injection. The main goal is to see if MAR001 reduces the rise in triglycerides and remnant chole…

This study compares low-glycemic index (GI) bakery foods like pasta and pizza to standard wholegrain versions in 40 adults with high triglycerides. The goal is to see if low-GI carbs improve a key marker of metabolic and heart risk more than wholegrain carbs. Participants follow …

This study is a registry that gathers information from up to 500 people in Russia who have extremely high triglyceride levels (a type of fat in the blood). The goal is to learn more about their health, genetics, and current treatments. No new drugs or procedures are tested—just o…

This study looks at how different types of insulin resistance (in fat or muscle) affect the liver's production of fats called triglycerides. Researchers will measure fat production after a meal, with and without exercise beforehand. The goal is to understand why some people have …

This early study is testing two types of fish oil—EPA and DHA—to see how they affect blood clotting and cholesterol in people with high triglycerides. Eighty participants will take one of the two oils for a month and have their blood tested. The goal is to learn which oil might b…

This study tests whether spinning blood samples at very high speed can remove fat particles that interfere with a key test for blood thinners. Researchers will add fat to routine blood samples from 150 adults on anti-Xa medications and see if the spinning method clears the fat wi…