HYPERTRIGLYCERIDEMIA

This study tests an experimental drug called MAR001 in 30 adults with high triglycerides, a type of fat in the blood. The goal is to see if MAR001 can lower fat levels after a meal better than a placebo. Participants must have stable eating habits and certain blood sugar levels.

This early-phase study tests a single dose of VERVE-201, a gene-editing therapy, in 36 adults with high cholesterol and triglycerides that don't respond to standard treatments. The goal is to see if it is safe and to measure how it affects blood fat levels. Participants must not …

This study tests a new medicine called JMT202, given as a shot under the skin, for people with very high triglycerides (a type of fat in the blood). The goal is to see if it is safe and how well it works. About 48 Chinese adults with high triglycerides will take part, and some wi…

This study tests whether adding chia seeds and pumpkin seeds to a standard heart-healthy diet can lower triglyceride levels in people with hypertriglyceridemia (high blood fats). About 375 adults with moderately high triglycerides will follow one of two diets for 4 weeks. The goa…

This study tests a new drug called RBD5044 in 40 adults with high triglycerides, a type of fat in the blood that can increase heart risk. Participants receive either the drug or a placebo twice over 12 weeks. The main goal is to see if the drug safely lowers triglyceride levels c…

This study is for adults with very high triglycerides, a type of fat in the blood that can increase the risk of pancreatitis and heart disease. Participants who completed a previous related study can join and will receive injections of plozasiran every 3 months for 2 years. The g…

This early-phase study tests a single-dose CRISPR treatment (CTX310) designed to edit a gene that controls fat levels in the blood. It is for adults aged 18 to 75 with severe high cholesterol or triglycerides that do not improve with standard medications. The main goal is to chec…

This study tests whether a time-saving, joint-friendly muscle stimulation technology (whole-body electromyostimulation) can lower resting blood pressure and improve other heart-related risk factors in people with mild high blood pressure and overweight. Researchers will compare t…

This study looks at how two different fish oils, EPA and DHA, affect blood clotting and cholesterol in people with high triglycerides. Researchers will give participants either EPA or DHA supplements and track changes in blood tests over several visits. The goal is to gather info…

This study looks at whether high-speed centrifugation (spinning blood very fast) can separate fat from plasma to allow accurate measurement of anti-Xa activity, a test that monitors blood thinners. About 150 adults on blood thinners will have their samples tested. The goal is to …

This study looks at how different types of insulin resistance affect the liver's fat production in people with high triglycerides. About 40 overweight adults will have their fat metabolism measured after a meal, with and without prior exercise. The goal is to understand the link …

This study is a registry that collects information from 500 people in Russia with extremely high triglyceride levels (a type of fat in the blood). The goal is to understand their health, genetics, and current treatments. No new treatments are tested; instead, researchers observe …