HYPERTRIGLYCERIDEMIA

This study is for adults with very high triglycerides, a type of fat in the blood that can increase the risk of pancreatitis and heart disease. Participants who completed a prior study will receive an injection of plozasiran every 3 months for 2 years. The goal is to see if the d…

This study tests whether adding chia seeds and pumpkin seeds to a heart-healthy diet can lower triglyceride levels in people with hypertriglyceridemia (high blood fats). About 375 adults with moderately high triglycerides will eat either a standard healthy diet or the same diet p…

This study tests an experimental drug called RBD5044 in 40 adults with high triglycerides, a type of blood fat that raises heart risk. Participants receive either the drug or a placebo twice over 12 weeks. The main goal is to see if RBD5044 safely lowers triglyceride levels.

This study tests an experimental drug called MAR001 in 30 adults with high triglycerides, a type of blood fat. The goal is to see if MAR001 lowers fat levels after a meal better than a placebo. Participants will take the drug or placebo and have their blood tested after eating a …

This early-phase study tests a single dose of VERVE-201, a gene-editing therapy, in 36 adults with high cholesterol and triglycerides that don't respond to standard treatments. The goal is to see if it is safe and how it affects blood fat levels. Participants must have refractory…

This study is testing a new treatment called CTX310, which uses CRISPR gene editing to turn off a gene linked to high cholesterol and fats. It is for adults aged 18 to 75 whose lipid levels remain high despite standard treatments. The goal is to see if the therapy is safe and can…

This study tests an experimental injection called JMT202 in people with very high triglycerides, a type of fat in the blood that can raise heart risk. About 48 Chinese adults will receive either the drug or a placebo to check safety and how well the body handles it. The goal is t…

This study looks at whether high-speed centrifugation can remove fat from blood samples so doctors can accurately measure anti-Xa activity, a key test for monitoring blood thinners. About 150 adults on anticoagulants will have their blood samples tested. The goal is to see if thi…

This study looks at how different types of insulin resistance (in fat or muscle) affect fat production in the liver. Researchers will measure fat levels in the blood after a meal, with and without exercise beforehand. The goal is to understand these processes better, not to test …

This early-stage study aims to understand how two different fish oils, EPA and DHA, affect blood clotting and cholesterol in people with high triglyceride levels. About 80 participants will be randomly assigned to take either EPA or DHA supplements for a period, with blood tests …

This study is a registry that gathers data from 500 people in Russia with extremely high triglycerides (a type of fat in the blood). The goal is to learn about their health, genetics, and current treatments. No new drugs or procedures are tested—just observation and record-keepin…