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New drug MAR001 aims to tackle stubborn high triglycerides

NCT ID NCT07028749

Ongoing Disease control Sponsor: Marea Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2b study tests whether the experimental drug MAR001 can lower high triglycerides and remnant cholesterol in adults. About 216 participants will receive either MAR001 or a placebo by injection. The main goal is to see if MAR001 reduces triglyceride levels more than placebo over the study period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

MAR001

What this could lead to

If successful, MAR001 could offer a new treatment option to lower high triglycerides and remnant cholesterol, potentially reducing heart disease risk.

What could go wrong

This is an early Phase 2b trial with only 216 participants, so results may not confirm effectiveness or safety. The drug may not work better than placebo or could have side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTRIGLYCERIDEMIA

Contacts and locations

Locations

  • Marea Site 101

    Nedlands, Western Australia, 6009, Australia

  • Marea Site 102

    Clayton, Victoria, 3168, Australia

  • Marea Site 103

    Canberra, Australian Capital Territory, 2617, Australia

  • Marea Site 104

    Milton, Queensland, 4064, Australia

  • Marea Site 105

    Kanwal, New South Wales, 2259, Australia

  • Marea Site 106

    Miranda, New South Wales, 2228, Australia

  • Marea Site 107

    Merewether, New South Wales, 2291, Australia

  • Marea Site 108

    Herston, Queensland, 4006, Australia

  • Marea Site 109

    Wollongong, New South Wales, 2500, Australia

  • Marea Site 110

    Heidelberg Heights, Victoria, 3081, Australia

  • Marea Site 111

    Leabrook, South Australia, 5068, Australia

  • Marea Site 112

    Perth, Western Australia, 6000, Australia

  • Marea Site 113

    Hoppers Crossing, Victoria, 3029, Australia

  • Marea Site 203

    Papatoetoe, Auckland, 2025, New Zealand

  • Marea Site 204

    Ebdentown, Upper Hutt, 5018, New Zealand

  • Marea Site 205

    Silverdale, Auckland, 0932, New Zealand

  • Marea Site 206

    Christchurch, South Island, 8013, New Zealand

  • Marea Site 207

    New Lynn, Auckland, 0600, New Zealand

  • Marea Site 208

    Rotorua, 3010, New Zealand

  • Marea Site 209

    Christchurch, 4710, New Zealand

  • Marea Site 211

    Birkenhead, Auckland, 0626, New Zealand

  • Marea Site 301

    Louisville, Kentucky, 40213, United States

  • Marea Site 302

    Boca Raton, Florida, 33434, United States

  • Marea Site 303

    Greensboro, North Carolina, 27405, United States

  • Marea Site 304

    Great Neck, New York, 11021, United States

  • Marea Site 305

    St Louis, Missouri, 63110, United States

  • Marea Site 306

    Hamden, Connecticut, 06517, United States

  • Marea Site 307

    Port Saint Lucie, Florida, 34952, United States

  • Marea Site 308

    McKinney, Texas, 75071, United States

  • Marea Site 309

    Tacoma, Washington, 98405, United States

  • Marea Site 310

    Columbus, Georgia, 31904, United States

  • Marea Site 312

    San Antonio, Texas, 78229, United States

  • Marea Site 313

    Little Rock, Arkansas, 72204, United States

  • Marea Site 314

    Greenville, South Carolina, 29607, United States

  • Marea Site 315

    Winston-Salem, North Carolina, 27104, United States

  • Marea Site 316

    Baltimore, Maryland, 21229, United States

  • Marea Site 317

    Park Ridge, Illinois, 60068, United States

  • Marea Site 318

    New Windsor, New York, 12553, United States

  • Marea Site 319

    Peachtree Corners, Georgia, 30092, United States

  • Marea Site 320

    Little River, South Carolina, 29566, United States

  • Marea Site 321

    Manassas, Virginia, 20109, United States

  • Marea Site 322

    Amarillo, Texas, 79124, United States

  • Marea Site 325

    Springfield, Illinois, 62702, United States

  • Marea Site 326

    Memphis, Tennessee, 38119, United States

  • Marea Site 328

    Anniston, Alabama, 36207, United States

  • Marea Site 329

    Mobile, Alabama, 36608, United States

  • Marea Site 330

    Kansas City, Missouri, 64151, United States

  • Marea Site 401

    Chicoutimi, Quebec, G7H 7K9, Canada

  • Marea Site 402

    Montreal, Quebec, H1T 1C8, Canada

  • Marea Site 403

    London, Ontario, N5W6A2, Canada

  • Marea Site 404

    Sarnia, Ontario, N7T 4X3, Canada

  • Marea Site 405

    Québec, Quebec, G1G 3Y8, Canada

  • Marea Site 406

    Concord, Ontario, L4K 4M2, Canada

  • Marea Site 407

    Québec, Quebec, G1V 4M6, Canada