New drug MAR001 aims to tackle stubborn high triglycerides

NCT ID NCT07028749

Recruiting now Disease control Sponsor: Marea Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This Phase 2b study tests whether the experimental drug MAR001 can lower high triglycerides and remnant cholesterol in adults. About 216 participants will receive either MAR001 or a placebo by injection. The main goal is to see if MAR001 reduces triglyceride levels more than placebo over the study period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MAR001
What this could lead to: If successful, MAR001 could offer a new treatment option to lower high triglycerides and remnant cholesterol, potentially reducing heart disease risk.
What could go wrong: This is an early Phase 2b trial with only 216 participants, so results may not confirm effectiveness or safety. The drug may not work better than placebo or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTRIGLYCERIDEMIA

Contacts and locations

Locations

Marea Site 101
RECRUITING

Nedlands, Western Australia, 6009, Australia
Marea Site 102
RECRUITING

Clayton, Victoria, 3168, Australia
Marea Site 103
RECRUITING

Canberra, Australian Capital Territory, 2617, Australia
Marea Site 104
RECRUITING

Milton, Queensland, 4064, Australia
Marea Site 105
RECRUITING

Kanwal, New South Wales, 2259, Australia
Marea Site 106
RECRUITING

Miranda, New South Wales, 2228, Australia
Marea Site 107
RECRUITING

Merewether, New South Wales, 2291, Australia
Marea Site 108
RECRUITING

Herston, Queensland, 4006, Australia
Marea Site 109
RECRUITING

Wollongong, New South Wales, 2500, Australia
Marea Site 110
RECRUITING

Heidelberg Heights, Victoria, 3081, Australia
Marea Site 111
RECRUITING

Leabrook, South Australia, 5068, Australia
Marea Site 112
RECRUITING

Perth, Western Australia, 6000, Australia
Marea Site 113
RECRUITING

Hoppers Crossing, Victoria, 3029, Australia
Marea Site 203
RECRUITING

Papatoetoe, Auckland, 2025, New Zealand
Marea Site 204
RECRUITING

Ebdentown, Upper Hutt, 5018, New Zealand
Marea Site 205
RECRUITING

Silverdale, Auckland, 0932, New Zealand
Marea Site 206
RECRUITING

Christchurch, South Island, 8013, New Zealand
Marea Site 207
RECRUITING

New Lynn, Auckland, 0600, New Zealand
Marea Site 208
RECRUITING

Rotorua, 3010, New Zealand
Marea Site 209
RECRUITING

Christchurch, 4710, New Zealand
Marea Site 211
RECRUITING

Birkenhead, Auckland, 0626, New Zealand
Marea Site 301
RECRUITING

Louisville, Kentucky, 40213, United States
Marea Site 302
RECRUITING

Boca Raton, Florida, 33434, United States
Marea Site 303
RECRUITING

Greensboro, North Carolina, 27405, United States
Marea Site 304
RECRUITING

Great Neck, New York, 11021, United States
Marea Site 305
RECRUITING

St Louis, Missouri, 63110, United States
Marea Site 306
RECRUITING

Hamden, Connecticut, 06517, United States
Marea Site 307
RECRUITING

Port Saint Lucie, Florida, 34952, United States
Marea Site 308
RECRUITING

McKinney, Texas, 75071, United States
Marea Site 309
RECRUITING

Tacoma, Washington, 98405, United States
Marea Site 310
RECRUITING

Columbus, Georgia, 31904, United States
Marea Site 312
RECRUITING

San Antonio, Texas, 78229, United States
Marea Site 313
RECRUITING

Little Rock, Arkansas, 72204, United States
Marea Site 314
RECRUITING

Greenville, South Carolina, 29607, United States
Marea Site 315
RECRUITING

Winston-Salem, North Carolina, 27104, United States
Marea Site 316
RECRUITING

Baltimore, Maryland, 21229, United States
Marea Site 317
RECRUITING

Park Ridge, Illinois, 60068, United States
Marea Site 318
RECRUITING

New Windsor, New York, 12553, United States
Marea Site 319
RECRUITING

Peachtree Corners, Georgia, 30092, United States
Marea Site 320
RECRUITING

Little River, South Carolina, 29566, United States
Marea Site 321
RECRUITING

Manassas, Virginia, 20109, United States
Marea Site 322
RECRUITING

Amarillo, Texas, 79124, United States
Marea Site 325
RECRUITING

Springfield, Illinois, 62702, United States
Marea Site 326
RECRUITING

Memphis, Tennessee, 38119, United States
Marea Site 328
RECRUITING

Anniston, Alabama, 36207, United States
Marea Site 329
RECRUITING

Mobile, Alabama, 36608, United States
Marea Site 330
RECRUITING

Kansas City, Missouri, 64151, United States
Marea Site 401
RECRUITING

Chicoutimi, Quebec, G7H 7K9, Canada
Marea Site 402
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Marea Site 403
RECRUITING

London, Ontario, N5W6A2, Canada
Marea Site 404
RECRUITING

Sarnia, Ontario, N7T 4X3, Canada
Marea Site 405
RECRUITING

Québec, Quebec, G1G 3Y8, Canada
Marea Site 406
RECRUITING

Concord, Ontario, L4K 4M2, Canada
Marea Site 407
RECRUITING

Québec, Quebec, G1V 4M6, Canada

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