New shot aims to tame dangerous fat levels in blood

NCT ID NCT07604974

Recruiting now Disease control Sponsor: Ionis Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests an injectable drug called ION775 in 72 adults with high or severely high triglycerides. The goal is to see if it safely lowers fasting triglyceride levels. Participants continue standard care while receiving the study drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ION775
What this could lead to: If successful, this could provide a new treatment option to lower dangerously high triglycerides, reducing risk of pancreatitis and heart disease.
What could go wrong: This is an early-phase, open-label trial with only 72 participants, so results may not confirm safety or effectiveness. Side effects and lack of a placebo group limit conclusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTRIGLYCERIDEMIA SEVERE HYPERTRIGLYCERIDEMIA

Contacts and locations

Locations

Ionis Investigative Site
RECRUITING

Lincoln, California, 95648, United States
Ionis Investigative Site
RECRUITING

Aurora, Colorado, 80045, United States
Ionis Investigative Site
RECRUITING

Boca Raton, Florida, 33434, United States
Ionis Investigative Site
RECRUITING

Miami, Florida, 33184, United States
Ionis Investigative Site
RECRUITING

Miramar, Florida, 33027, United States
Ionis Investigative Site
RECRUITING

Columbus, Georgia, 31904, United States
Ionis Investigative Site
RECRUITING

Louisville, Kentucky, 40213, United States
Ionis Investigative Site
RECRUITING

Flint, Michigan, 48504, United States
Ionis Investigative Site
RECRUITING

Munroe Falls, Ohio, 44262, United States
Ionis Investigative Site
RECRUITING

Little River, South Carolina, 29566, United States
Ionis Investigative Site
RECRUITING

Houston, Texas, 77040, United States
Ionis Investigative Site
RECRUITING

Lampasas, Texas, 76550, United States
Ionis Investigative Site
RECRUITING

McKinney, Texas, 75071, United States
Ionis Investigative Site
RECRUITING

Mesquite, Texas, 75071, United States
Ionis Investigative Site
RECRUITING

San Antonio, Texas, 78209, United States
Ionis Investigative Site
RECRUITING

Québec, G1V 4W2, Canada

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