New shot aims to tame dangerous fat levels in blood
NCT ID NCT07604974
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests an injectable drug called ION775 in 72 adults with high or severely high triglycerides. The goal is to see if it safely lowers fasting triglyceride levels. Participants continue standard care while receiving the study drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ION775
What this could lead to
If successful, this could provide a new treatment option to lower dangerously high triglycerides, reducing risk of pancreatitis and heart disease.
What could go wrong
This is an early-phase, open-label trial with only 72 participants, so results may not confirm safety or effectiveness. Side effects and lack of a placebo group limit conclusions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ionis Investigative Site
RECRUITINGLincoln, California, 95648, United States
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Ionis Investigative Site
RECRUITINGAurora, Colorado, 80045, United States
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Ionis Investigative Site
RECRUITINGBoca Raton, Florida, 33434, United States
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Ionis Investigative Site
RECRUITINGMiami, Florida, 33184, United States
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Ionis Investigative Site
RECRUITINGMiramar, Florida, 33027, United States
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Ionis Investigative Site
RECRUITINGColumbus, Georgia, 31904, United States
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Ionis Investigative Site
RECRUITINGLouisville, Kentucky, 40213, United States
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Ionis Investigative Site
RECRUITINGFlint, Michigan, 48504, United States
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Ionis Investigative Site
RECRUITINGMunroe Falls, Ohio, 44262, United States
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Ionis Investigative Site
RECRUITINGLittle River, South Carolina, 29566, United States
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Ionis Investigative Site
RECRUITINGHouston, Texas, 77040, United States
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Ionis Investigative Site
RECRUITINGLampasas, Texas, 76550, United States
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Ionis Investigative Site
RECRUITINGMcKinney, Texas, 75071, United States
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Ionis Investigative Site
RECRUITINGMesquite, Texas, 75071, United States
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Ionis Investigative Site
RECRUITINGSan Antonio, Texas, 78209, United States
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Ionis Investigative Site
RECRUITINGQuébec, G1V 4W2, Canada