New drug aims to tame dangerous fat levels in blood

NCT ID NCT05852431

Completed Disease control Sponsor: 89bio, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called pegozafermin in 369 adults with severe hypertriglyceridemia, a condition where blood fat levels are dangerously high. Participants received either the drug or a placebo for 26 weeks. The main goal was to see if the drug could safely lower triglyceride levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pegozafermin

What this could lead to

If it works, this could provide a new treatment option to lower dangerously high triglycerides and reduce the risk of pancreatitis and heart disease.

What could go wrong

This is a completed Phase 3 trial, but results are not yet public. The drug may not work better than placebo, and side effects are possible with any new medication.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Dyslipidemias hyperlipidemia hypertriglyceridemia Lipid Metabolism Disorders metabolic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE HYPERTRIGLYCERIDEMIA

Contacts and locations

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Locations

89 Clinical Study Site

Austin, Texas, 78757, United States
89Bio Clinical Study Site

Tucson, Arizona, 85712, United States
89Bio Clinical Study Site

Long Beach, California, 90815, United States
89Bio Clinical Study Site

Tustin, California, 92780, United States
89Bio Clinical Study Site

Clearwater, Florida, 33756, United States
89Bio Clinical Study Site

Homestead, Florida, 33030, United States
89Bio Clinical Study Site

Miami Lakes, Florida, 33014, United States
89Bio Clinical Study Site

Orlando, Florida, 32825, United States
89Bio Clinical Study Site

Tampa, Florida, 33606, United States
89Bio Clinical Study Site

Columbus, Georgia, 31904, United States
89Bio Clinical Study Site

Lawrenceville, Georgia, 30044, United States
89Bio Clinical Study Site

Chicago, Illinois, 60607, United States
89Bio Clinical Study Site

Wichita, Kansas, 67205, United States
89Bio Clinical Study Site

Marrero, Louisiana, 70072, United States
89Bio Clinical Study Site

Oxon Hill, Maryland, 20745, United States
89Bio Clinical Study Site

North Massapequa, New York, 11758, United States
89Bio Clinical Study Site

Morganton, North Carolina, 28655, United States
89Bio Clinical Study Site

Eugene, Oregon, 97404, United States
89Bio Clinical Study Site

Chattanooga, Tennessee, 37421, United States
89Bio Clinical Study Site

Lampasas, Texas, 76550, United States
89Bio Clinical Study Site

Burke, Virginia, 22015, United States
89Bio Clinical Study Site

San Juan, 00927, Puerto Rico
89bio Clincal Study Site

London, N128BU, United Kingdom
89bio Clinical Study Site

Chandler, Arizona, 85712, United States
89bio Clinical Study Site

Peoria, Arizona, 85381, United States
89bio Clinical Study Site

Conway, Arkansas, 72032, United States
89bio Clinical Study Site

Jonesboro, Arkansas, 72401, United States
89bio Clinical Study Site

Little Rock, Arkansas, 72205, United States
89bio Clinical Study Site

Los Angeles, California, 90057, United States
89bio Clinical Study Site

Santa Ana, California, 92705, United States
89bio Clinical Study Site

Thousand Oaks, California, 91360, United States
89bio Clinical Study Site

Wheat Ridge, Colorado, 80033, United States
89bio Clinical Study Site

Bridgeport, Connecticut, 06610, United States
89bio Clinical Study Site

Clearwater, Florida, 33761, United States
89bio Clinical Study Site

Hialeah Gardens, Florida, 33016, United States
89bio Clinical Study Site

Miramar, Florida, 33027, United States
89bio Clinical Study Site

Panama City, Florida, 32401, United States
89bio Clinical Study Site

Atlanta, Georgia, 30309, United States
89bio Clinical Study Site

West Des Moines, Iowa, 50265, United States
89bio Clinical Study Site

Flint, Michigan, 48504, United States
89bio Clinical Study Site

St Louis, Missouri, 63110, United States
89bio Clinical Study Site

Las Vegas, Nevada, 89106, United States
89bio Clinical Study Site

Las Vegas, Nevada, 89118, United States
89bio Clinical Study Site

East Syracuse, New York, 13057, United States
89bio Clinical Study Site

Cincinnati, Ohio, 45227, United States
89bio Clinical Study Site

Middleburg Heights, Ohio, 44130, United States
89bio Clinical Study Site

Stow, Ohio, 44224, United States
89bio Clinical Study Site

Oklahoma City, Oklahoma, 73102, United States
89bio Clinical Study Site

Charleston, South Carolina, 29414, United States
89bio Clinical Study Site

Tullahoma, Tennessee, 37388, United States
89bio Clinical Study Site

Amarillo, Texas, 79106, United States
89bio Clinical Study Site

Dallas, Texas, 75226, United States
89bio Clinical Study Site

Graham, Texas, 76450, United States
89bio Clinical Study Site

Houston, Texas, 77030, United States
89bio Clinical Study Site

Mansfield, Texas, 76063, United States
89bio Clinical Study Site

San Antonio, Texas, 78209, United States
89bio Clinical Study Site

Wichita Falls, Texas, 76301, United States
89bio Clinical Study Site

Rosario, Santa Fe Province, 2000, Argentina
89bio Clinical Study Site

Buenos Aires, C1023AAB, Argentina
89bio Clinical Study Site

Buenos Aires, C1425CABA, Argentina
89bio Clinical Study Site

Buenos Aires, C1426ABP, Argentina
89bio Clinical Study Site

Córdoba, 5000, Argentina
89bio Clinical Study Site

Córdoba, 5749, Argentina
89bio Clinical Study Site

Córdoba, X5000 BSQ, Argentina
89bio Clinical Study Site

Córdoba, X5000AAX, Argentina
89bio Clinical Study Site

Córdoba, X5004CDT, Argentina
89bio Clinical Study Site

Mendoza, M5509, Argentina
89bio Clinical Study Site

Rosario, S2000CVD, Argentina
89bio Clinical Study Site

San Miguel de Tucumán, T400IHE, Argentina
89bio Clinical Study Site

Viedma, R8500ACE, Argentina
89bio Clinical Study Site

Graz, A-8036, Austria
89bio Clinical Study Site

Edegem, 2650, Belgium
89bio Clinical Study Site

Ghent, 9000, Belgium
89bio Clinical Study Site

Haine-Saint-Paul, 7100, Belgium
89bio Clinical Study Site

Yvoir, 5530, Belgium
89bio Clinical Study Site

Dimitrovgrad, 6400, Bulgaria
89bio Clinical Study Site

Sliven, 8800, Bulgaria
89bio Clinical Study Site

Sofia, 1336, Bulgaria
89bio Clinical Study Site

Sofia, 1431, Bulgaria
89bio Clinical Study Site

Sofia, 1606, Bulgaria
89bio Clinical Study Site

Sofia, 1618, Bulgaria
89bio Clinical Study Site

Veliko Tarnovo, 5000, Bulgaria
89bio Clinical Study Site

North Vancouver, British Columbia, V7M 2H4, Canada
89bio Clinical Study Site

Brampton, Ontario, L6R3J7, Canada
89bio Clinical Study Site

Chicoutimi, Quebec, G7H 7K9, Canada
89bio Clinical Study Site

Laval, Quebec, H7T2P5, Canada
89bio Clinical Study Site

Montreal, Quebec, H2W1R7, Canada
89bio Clinical Study Site

Québec, Quebec, G1V 4G5, Canada
89bio Clinical Study Site

Concepción, 4030000, Chile
89bio Clinical Study Site

Santiago, 8330336, Chile
89bio Clinical Study Site

Santiago, 8910259, Chile
89bio Clinical Study Site

Valdivia, 5090000, Chile
89bio Clinical Study Site

Viña del Mar, 2520997, Chile
89bio Clinical Study Site

Brno, 60200, Czechia
89bio Clinical Study Site

Brno, 65691, Czechia
89bio Clinical Study Site

Prague, 12808, Czechia
89bio Clinical Study Site

Prague, 14021, Czechia
89bio Clinical Study Site

Prague, 15006, Czechia
89bio Clinical Study Site

Marseille, 13005, France
89bio Clinical Study Site

Paris, 75013, France
89bio Clinical Study Site

Valenciennes, 59300, France
89bio Clinical Study Site

Batumi, 6000, Georgia
89bio Clinical Study Site

Tbilisi, 0160, Georgia
89bio Clinical Study Site

Tbilisi, 0177, Georgia
89bio Clinical Study Site

Tbilisi, 0186, Georgia
89bio Clinical Study Site

Essen, 45147, Germany
89bio Clinical Study Site

Leipzig, 27 04103, Germany
89bio Clinical Study Site

Baja, Hungary
89bio Clinical Study Site

Nyíregyháza, 4400, Hungary
89bio Clinical Study Site

Belagāve, 590010, India
89bio Clinical Study Site

Bīkaner, 334001, India
89bio Clinical Study Site

Dehradun, 248001, India
89bio Clinical Study Site

Jaipur, 302017, India
89bio Clinical Study Site

Nagpur, 441108, India
89bio Clinical Study Site

Pimpri-Chinchwad, 411057, India
89bio Clinical Study Site

Varanasi, 221010, India
89bio Clinical Study Site

Milan, 20138, Italy
89bio Clinical Study Site

Modena, 41126, Italy
89bio Clinical Study Site

Reggio Emilia, 42123, Italy
89bio Clinical Study Site

Daugavpils, Latvia
89bio Clinical Study Site

Zemgale, 1002, Latvia
89bio Clinical Study Site

Monterrey, Nuevo León, 64310, Mexico
89bio Clinical Study Site

Cuernavaca, Mexico
89bio Clinical Study Site

General Escobedo, 66050, Mexico
89bio Clinical Study Site

Guadalajara, 76100, Mexico
89bio Clinical Study Site

Querétaro City, 76100, Mexico
89bio Clinical Study Site

Tlalpan, 14080, Mexico
89bio Clinical Study Site

Bialystok, 15-351, Poland
89bio Clinical Study Site

Krakow, 30-348, Poland
89bio Clinical Study Site

Krakow, 31-501, Poland
89bio Clinical Study Site

Lodz, 91-363, Poland
89bio Clinical Study Site

Lodz, 93-338, Poland
89bio Clinical Study Site

Lublin, 20-362, Poland
89bio Clinical Study Site

Warsaw, 00-215, Poland
89bio Clinical Study Site

Barcelona, 08036, Spain
89bio Clinical Study Site

Barcelona, 08041, Spain
89bio Clinical Study Site

Barcelona, 08907, Spain
89bio Clinical Study Site

Cadiz, 11009, Spain
89bio Clinical Study Site

Córdoba, 14004, Spain
89bio Clinical Study Site

Granada, 18014, Spain
89bio Clinical Study Site

Granada, 18016, Spain
89bio Clinical Study Site

Huelva, 21005, Spain
89bio Clinical Study Site

Madrid, 28041, Spain
89bio Clinical Study Site

Málaga, 29004, Spain
89bio Clinical Study Site

Pamplona, 31008, Spain
89bio Clinical Study Site

Cardiff, CF14 4XW, United Kingdom
89bio Clinical Study Sites

Sparta, New Jersey, 07871, United States
89bio Clinical Trial Site

Huntington Park, California, 90255, United States
89bio Clinical Trial Site

Northridge, California, 91325, United States
89bio Clinical Trial Site

Panorama City, California, 91402, United States
89bio Clinical Trial Site

Santa Ana, California, 92705, United States
89bio Clinical Trial Site

Wheat Ridge, Colorado, 80033, United States
89bio Clinical Trial Site

Port Orange, Florida, 32127, United States
89bio Clinical Trial Site

Shreveport, Louisiana, 71105, United States
89bio Clinical Trial Site

Kansas City, Missouri, 64131, United States
89bio Clinical Trial Site

New Windsor, New York, 12553, United States
89bio Clinical Trial Site

New York, New York, 10029, United States
89bio Clinical Trial Site

Richmond Hill, New York, 77379, United States
89bio Clinical Trial Site

Syracuse, New York, 13057, United States
89bio Clinical Trial Site

Columbus, Ohio, 43213, United States
89bio Clinical Trial Site

Clarksville, Tennessee, 37040, United States
89bio Clinical Trial Site

San Antonio, Texas, 78207, United States
89bio Clinical Trial Site

Salt Lake City, Utah, 84107, United States
89bio Clinical Trial Site

Richmond, Virginia, 23249, United States
89bio Clinical Trial Site

Vienna, 1030, Austria
89bio Clinical Trial Site

Vienna, 1130, Austria
89bio Clinical Trial Site

Botevgrad, 2140, Bulgaria
89bio Clinical Trial Site

Plovdiv, 4004, Bulgaria
89bio Clinical Trial Site

Sliven, 8800, Bulgaria
89bio Clinical Trial Site

Sofia, 1202, Bulgaria
89bio Clinical Trial Site

Veliko Tarnovo, 5000, Bulgaria
89bio Clinical Trial Site

Kutaisi, 4600, Georgia
89bio Clinical Trial Site

Tbilisi, 0159, Georgia
89bio Clinical Trial Site

Balatonfüred, 8230, Hungary
89bio Clinical Trial Site

Budapest, 1122, Hungary
89bio Clinical Trial Site

Riga, 1002, Latvia
89bio Cllinical Study Site

Genova, 16132, Italy