New drug shows promise for controlling dangerous fat levels in blood

NCT ID NCT06822790

Recruiting now Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study tests the long-term safety and effectiveness of a drug called plozasiran in adults with very high triglycerides (a type of fat in the blood). About 869 people who completed earlier studies will receive injections every 3 months for 2 years. The goal is to see if the drug can safely lower triglyceride levels and reduce related health risks.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTRIGLYCERIDEMIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site 1
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Miami Lakes, Florida, 33014, United States
Research Site 10
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Manassas, Virginia, 20110, United States
Research Site 100
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Dimitrovgrad, 6400, Bulgaria
Research Site 101
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Sarnia, Ontario, N7T 4X3, Canada
Research Site 102
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Waterloo, Ontario, N2T 0C1, Canada
Research Site 103
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Halifax, Nova Scotia, NS B3H 1V7, Canada
Research Site 104
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Beijing, Beijing Municipality, 100034, China
Research Site 105
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Yuncheng, Shanxi, 44000, China
Research Site 106
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Xingtai, Hebei, 054099, China
Research Site 107
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Changsha, Hu'nan, 410011, China
Research Site 108
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Changsha, Hu'nan, 410015, China
Research Site 109
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Wenzhou, Zhejiang, 325000, China
Research Site 11
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Canoga Park, California, 91303, United States
Research Site 110
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Nanchang, Jiangxi, 330006, China
Research Site 111
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Guangzhou, Guangdong, 510180, China
Research Site 112
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Guangzhou, Guangdong, 510080, China
Research Site 113
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Chengdu, Sichuan, 610072, China
Research Site 114
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Liuzhou, Guangxi Zhuang, 545006, China
Research Site 115
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Baotou, Inner Mongolia, 014010, China
Research Site 116
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Praha 4-Krc, 140 59, Czechia
Research Site 117
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Hodonín, 69501, Czechia
Research Site 118
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Olomouc, CZ77900, Czechia
Research Site 119
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Prague, 11000, Czechia
Research Site 12
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Annapolis, Maryland, 21401, United States
Research Site 120
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Pessac, Gironde, 33604, France
Research Site 121
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Pécs, 7623, Hungary
Research Site 122
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Budapest, 1132, Hungary
Research Site 123
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Budapest, 1051, Hungary
Research Site 124
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Daugavpils, LV-5417, Latvia
Research Site 125
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Riga, LV1063, Latvia
Research Site 126
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Kaunas, 49387, Lithuania
Research Site 127
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Šiauliai, LT-76206, Lithuania
Research Site 128
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Christchurch, 08011, New Zealand
Research Site 129
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Wellington, 6021, New Zealand
Research Site 13
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Sugar Land, Texas, 77479, United States
Research Site 130
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Elblag, 82-300, Poland
Research Site 131
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Lodz, 94-255, Poland
Research Site 132
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Malbork, 82-200, Poland
Research Site 133
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Wroclaw, 51-314, Poland
Research Site 134
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Katowice, 40-156, Poland
Research Site 135
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Szczecin, 71- 500, Poland
Research Site 136
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Lodz, 91-363, Poland
Research Site 137
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Żarów, 58-130, Poland
Research Site 138
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Krakow, 31-501, Poland
Research Site 139
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Warsaw, 00-215, Poland
Research Site 14
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Hialeah, Florida, 33016, United States
Research Site 140
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Wroclaw, 53-673, Poland
Research Site 141
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Katowice, 40-752, Poland
Research Site 142
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Bucharest, 010192, Romania
Research Site 143
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Ploieşti, 100342, Romania
Research Site 144
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Târgu Mureş, 540136, Romania
Research Site 145
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Timișoara, 300362, Romania
Research Site 146
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Košice, 04001, Slovakia
Research Site 147
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Bardejov, 08501, Slovakia
Research Site 148
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Rožňava, 048 01, Slovakia
Research Site 149
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Somerset West, Western Cape, 7130, South Africa
Research Site 15
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Bountiful, Utah, 84010, United States
Research Site 150
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Seville, 41013, Spain
Research Site 151
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Zaragoza, 50009, Spain
Research Site 152
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Plymouth, Devon, PL5 3JB, United Kingdom
Research Site 153
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Torquay, Devon, TQ2 7AA, United Kingdom
Research Site 154
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Miami, Florida, 33144, United States
Research Site 155
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Fort Lauderdale, Florida, 33308, United States
Research Site 156
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Long Island City, New York, 11106, United States
Research Site 157
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Indianapolis, Indiana, 46290, United States
Research Site 158
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Houston, Texas, 77061, United States
Research Site 159
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Orlando, Florida, 32825, United States
Research Site 16
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Tamarac, Florida, 33321, United States
Research Site 160
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Fort Worth, Texas, 76132, United States
Research Site 161
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Plano, Texas, 75093, United States
Research Site 162
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Mt. Dora, Florida, 32757, United States
Research Site 163
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Houston, Texas, 77090, United States
Research Site 164
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Norman, Oklahoma, 73072, United States
Research Site 165
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Summit, New Jersey, 07901, United States
Research Site 166
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Baltimore, Maryland, 21229, United States
Research Site 167
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Elkhart, Indiana, 46514-2487, United States
Research Site 168
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San Antonio, Texas, 78230, United States
Research Site 169
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Wilmington, North Carolina, 28401, United States
Research Site 17
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Park Ridge, Illinois, 60068, United States
Research Site 170
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Tomball, Texas, 77375, United States
Research Site 171
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Córdoba, X5000AAW, Argentina
Research Site 172
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Ciudad Autonoma Buenos Aires, 1425, Argentina
Research Site 173
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Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
Research Site 174
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Nedlands, Western Australia, 6009, Australia
Research Site 175
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Roeselare, 8800, Belgium
Research Site 176
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Votuporanga, São Paulo, 15500-269, Brazil
Research Site 177
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São Paulo, 04266-010, Brazil
Research Site 178
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Belo Horizonte, Minas Gerais, 30150-274, Brazil
Research Site 179
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São Paulo, 05403-900, Brazil
Research Site 18
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Tampa, Florida, 33614, United States
Research Site 180
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Campinas, São Paulo, 13060-080, Brazil
Research Site 181
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Aracaju, Sergipe, 49055-530, Brazil
Research Site 182
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Sofia, 1431, Bulgaria
Research Site 183
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Sofia, 1431, Bulgaria
Research Site 184
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Sofia, 1527, Bulgaria
Research Site 185
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Plovdiv, 4001, Bulgaria
Research Site 186
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Sofia, 1431, Bulgaria
Research Site 187
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Burgas, 8000, Bulgaria
Research Site 188
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Luoyang, Henan, 471003, China
Research Site 189
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Shanghai, Shanghai Municipality, 200050, China
Research Site 19
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Québec, G1G5X1, Canada
Research Site 190
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Liaocheng, Shandong, 252000, China
Research Site 191
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Bengbu, Anhui, 233004, China
Research Site 192
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Suzhou, Jiangsu, 215002, China
Research Site 193
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Beijing, Beijing Municipality, 100091, China
Research Site 194
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Zagreb, 10000, Croatia
Research Site 195
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Ústí nad Labem, 40113, Czechia
Research Site 196
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Trutnov, 541 01, Czechia
Research Site 197
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Hradec Králové, 50005, Czechia
Research Site 198
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Teplice, 41501, Czechia
Research Site 199
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Marseille, Bouches-du-Rhône, 13005, France
Research Site 2
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Jefferson City, Missouri, 65109, United States
Research Site 20
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Victoria, British Columbia, V8T5G4, Canada
Research Site 200
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Paris, Paris, 75013, France
Research Site 201
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Magdeburg, Saxony-Anhalt, 39120, Germany
Research Site 202
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Veszprém, 8200, Hungary
Research Site 203
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Zalaegerszeg, 8900, Hungary
Research Site 204
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Budapest, 1033, Hungary
Research Site 205
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Miskolc, 3530, Hungary
Research Site 206
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Roma, 00168, Italy
Research Site 207
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Milan, 20162, Italy
Research Site 208
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Brescia, 25123, Italy
Research Site 209
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Rozzano, Milano, 20089, Italy
Research Site 21
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Bakersfield, California, 93311, United States
Research Site 210
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Palermo, 90127, Italy
Research Site 211
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Riga, LV-1002, Latvia
Research Site 212
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Daugavpils, LV-5410, Latvia
Research Site 213
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Kaunas, LT-50177, Lithuania
Research Site 214
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Vilnius, LT-08661, Lithuania
Research Site 215
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Zamość, 22-400, Poland
Research Site 216
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Warsaw, 03-291, Poland
Research Site 217
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Galati, 800291, Romania
Research Site 218
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Moldava nad Bodvou, 045 01, Slovakia
Research Site 219
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Krugersdorp, Gauteng, 1739, South Africa
Research Site 22
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Beavercreek, Ohio, 45431, United States
Research Site 220
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Cape Town, Western Cape, 7570, South Africa
Research Site 221
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Cape Town, Western Cape, 7925, South Africa
Research Site 222
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Cape Town, Western Cape, 7500, South Africa
Research Site 223
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Barcelona, 08035, Spain
Research Site 224
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A Coruña, La Coruña, 15006, Spain
Research Site 225
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Valencia, 46010, Spain
Research Site 226
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Madrid, 28041, Spain
Research Site 227
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London, Greater London, EC1M 6BQ, United Kingdom
Research Site 228
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New York, New York, 10029, United States
Research Site 229
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Palm Springs, California, 92262, United States
Research Site 23
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Topeka, Kansas, 66606, United States
Research Site 230
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Missouri City, Texas, 77459, United States
Research Site 231
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Philadelphia, Pennsylvania, 19104, United States
Research Site 232
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St Louis, Missouri, 63136, United States
Research Site 233
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New York, New York, 10016, United States
Research Site 234
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Columbus, Ohio, 43214, United States
Research Site 235
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Huntington Beach, California, 92648, United States
Research Site 236
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Lake Forest, California, 92630, United States
Research Site 237
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Lawrenceville, Georgia, 30044, United States
Research Site 238
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Fort Mill, South Carolina, 29707, United States
Research Site 239
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Córdoba, X5006CBI, Argentina
Research Site 24
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Houston, Texas, 77095, United States
Research Site 240
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Córdoba, X5008HHW, Argentina
Research Site 241
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Toronto, Ontario, M5G 2C4, Canada
Research Site 242
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Tianjin, Tianjin Municipality, 300121, China
Research Site 243
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Shanghai, Shanghai Municipality, 200040, China
Research Site 244
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Prague, 140 21, Czechia
Research Site 245
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Bologna, 40138, Italy
Research Site 246
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Kaunas, 49449, Lithuania
Research Site 247
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Gdynia, 81-338, Poland
Research Site 248
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Nitra, 950 01, Slovakia
Research Site 249
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Rosario, 2000, Argentina
Research Site 25
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Victoria, Texas, 77901, United States
Research Site 250
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Ciudad Autonoma Buenos Aires, Buenos Aires, C1128AAF, Argentina
Research Site 251
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Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Research Site 252
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Heidelberg Heights, Victoria, 3081, Australia
Research Site 253
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Clayton, Victoria, 3168, Australia
Research Site 254
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Belém, Pará, 66073-000, Brazil
Research Site 255
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Belo Horizonte, Minas Gerais, 30220-140, Brazil
Research Site 256
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Canoas, Rio Grande do Sul, 92425-900, Brazil
Research Site 257
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Brasília, Federal District, 70710-100, Brazil
Research Site 258
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Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Research Site 259
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Salvador, Estado de Bahia, 41810-010, Brazil
Research Site 26
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Horsham, Pennsylvania, 19044, United States
Research Site 260
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Sofia, 1582, Bulgaria
Research Site 261
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Wuhan, Hubei, 430060, China
Research Site 262
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Karlovac, 47000, Croatia
Research Site 263
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Slaný, 27401, Czechia
Research Site 264
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Náchod, 547 01, Czechia
Research Site 265
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Budapest, 1152, Hungary
Research Site 266
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Vilnius, LT-08661, Lithuania
Research Site 267
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Wroclaw, 53-030, Poland
Research Site 268
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Banská Bystrica, 97401, Slovakia
Research Site 269
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Mossel Bay, Western Cape, 6500, South Africa
Research Site 27
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El Paso, Texas, 19044, United States
Research Site 270
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Pretoria, Gauteng, 0181, South Africa
Research Site 271
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Barcelona, 08023, Spain
Research Site 272
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Houston, Texas, 77030, United States
Research Site 273
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Riverhead, New York, 12401, United States
Research Site 274
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Seattle, Washington, 98109, United States
Research Site 275
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Redding, California, 96001, United States
Research Site 276
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Ciudad Autonoma Buenos Aires, C1417, Argentina
Research Site 277
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Buenos Aires, C1056ABI, Argentina
Research Site 278
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Córdoba, 5000, Argentina
Research Site 279
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Campina Grande do Sul, 83430-000, Brazil
Research Site 28
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Overland Park, Kansas, 66211, United States
Research Site 280
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Salvador, 40323-010, Brazil
Research Site 281
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Salvador, 40170310, Brazil
Research Site 282
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Sofia, 1510, Bulgaria
Research Site 283
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Sofia, 1756, Bulgaria
Research Site 284
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Deggingen, 73326, Germany
Research Site 285
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Berlin, 13353, Germany
Research Site 286
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Szeged, 6725, Hungary
Research Site 287
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Riga, LV-1038, Latvia
Research Site 288
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Cape Town, 7530, South Africa
Research Site 289
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Santiago de Compostela, 15706, Spain
Research Site 29
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Fremont, Nebraska, 68025, United States
Research Site 290
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Minneapolis, Minnesota, 55455, United States
Research Site 291
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Houston, Texas, 77074, United States
Research Site 292
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Houston, Texas, 77030, United States
Research Site 293
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Chattanooga, Tennessee, 37411, United States
Research Site 294
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Vandalia, Ohio, 45377, United States
Research Site 3
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Omaha, Nebraska, 68144, United States
Research Site 30
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Flint, Michigan, 48532, United States
Research Site 31
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Oklahoma City, Oklahoma, 73112, United States
Research Site 32
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Olive Branch, Mississippi, 38654, United States
Research Site 33
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Jackson, Mississippi, 39202, United States
Research Site 34
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Oxnard, California, 93030, United States
Research Site 35
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St. George, Utah, 84790, United States
Research Site 36
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Morehead City, North Carolina, 28557, United States
Research Site 37
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Asheboro, North Carolina, 27203, United States
Research Site 38
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North Miami, Florida, 33162, United States
Research Site 39
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Lincoln, California, 95648, United States
Research Site 4
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Québec, Quebec, G1V 4W2, Canada
Research Site 40
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Garden Grove, California, 92844, United States
Research Site 41
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Orlando, Florida, 32825, United States
Research Site 42
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Mt. Dora, Florida, 32757, United States
Research Site 43
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Elkhart, Indiana, 46514, United States
Research Site 44
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Baltimore, Maryland, 21229, United States
Research Site 45
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Wetteren, 9230, Belgium
Research Site 46
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Namur, 5000, Belgium
Research Site 47
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Mechelen, 2800, Belgium
Research Site 48
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Gozée, 6534, Belgium
Research Site 49
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Pleven, 5800, Bulgaria
Research Site 5
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Montreal, Quebec, H2W 1R7, Canada
Research Site 50
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Plovdiv, 4002, Bulgaria
Research Site 51
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Sofia, 1616, Bulgaria
Research Site 52
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Kyustendil, 2500, Bulgaria
Research Site 53
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Sofia, 1404, Bulgaria
Research Site 54
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Kardzhali, 6600, Bulgaria
Research Site 55
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Sarnia, Ontario, N7T 4X3, Canada
Research Site 56
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Kitchener, N2H5Z8, Canada
Research Site 57
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Beijing, Beijing Municipality, 100034, China
Research Site 58
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Yuncheng, Shanxi, 44000, China
Research Site 59
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Changsha, Hu'nan, 410011, China
Research Site 6
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Chicoutimi, Quebec, G7H 7K9, Canada
Research Site 60
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Wenzhou, Zhejiang, 325000, China
Research Site 61
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Nanchang, Jiangxi, 330006, China
Research Site 62
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Guangzhou, Guangdong, 510000, China
Research Site 63
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Liuzhou, Guangxi Zhuang, 545006, China
Research Site 64
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Baotou, Inner Mongolia, 14010, China
Research Site 65
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Hodonín, 69501, Czechia
Research Site 66
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Prague, 11000, Czechia
Research Site 67
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Pécs, 7623, Hungary
Research Site 68
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Budapest, 1132, Hungary
Research Site 69
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Riga, LV1063, Latvia
Research Site 7
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London, Ontario, N6A 5K8, Canada
Research Site 70
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Kaunas, 49387, Lithuania
Research Site 71
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Plymouth, Devon, PL5 3JB, United Kingdom
Research Site 72
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Long Island City, New York, 11106, United States
Research Site 73
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Houston, Texas, 77061, United States
Research Site 74
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Plano, Texas, 75093, United States
Research Site 75
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Houston, Texas, 77090, United States
Research Site 76
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Norman, Oklahoma, 73072, United States
Research Site 77
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Summit, New Jersey, 07901, United States
Research Site 78
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Elblag, 82-300, Poland
Research Site 79
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Lodz, 94-255, Poland
Research Site 8
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Newport, Pennsylvania, 17074, United States
Research Site 80
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Malbork, 82-200, Poland
Research Site 81
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Katowice, 40-156, Poland
Research Site 82
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Żarów, 58-130, Poland
Research Site 83
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Krakow, 31-501, Poland
Research Site 84
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Warsaw, 00-215, Poland
Research Site 85
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Katowice, 40-752, Poland
Research Site 86
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Box Hill, Victoria, 3128, Australia
Research Site 87
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Hasselt, 3500, Belgium
Research Site 88
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Wetteren, 9230, Belgium
Research Site 89
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Namur, 5380, Belgium
Research Site 9
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Beverly Hills, California, 90211, United States
Research Site 90
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Mechelen, 97770, Belgium
Research Site 91
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Gozée, 6534, Belgium
Research Site 92
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Pleven, 5800, Bulgaria
Research Site 93
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Plovdiv, 4002, Bulgaria
Research Site 94
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Rousse, 7013, Bulgaria
Research Site 95
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Sofia, 1616, Bulgaria
Research Site 96
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Kyustendil, 2500, Bulgaria
Research Site 97
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Sofia, 1618, Bulgaria
Research Site 98
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Kardzhali, 6600, Bulgaria
Research Site 99
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Stara Zagora, 6010, Bulgaria

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