Could a daily pill help kids with inherited high cholesterol?
NCT ID NCT05694260
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This study tests bempedoic acid, a cholesterol-lowering tablet, in children aged 6 to 17 with heterozygous familial hypercholesterolemia (HeFH), an inherited condition causing very high cholesterol. Researchers measure how the drug moves through the body and how well it lowers cholesterol over 8 weeks. The goal is to find a safe and effective dose for this age group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- bempedoic acid, a daily tablet that lowers cholesterol
- What this could lead to
- If successful, this could provide a new treatment option for children with inherited high cholesterol who cannot take or need more than statins.
- What could go wrong
- This is a small, early-phase study focused on drug levels and safety, not yet proving long-term benefit. Side effects or lack of effectiveness may emerge in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Amsterdam UMC - Locatie AMC
Amsterdam, 1105 AZ, Netherlands
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Cardiology Care for Children
Lancaster, Pennsylvania, 17601, United States
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Corporacio Sanitaria Parc Tauli - Hospital de Sabadell
Barcelona, 8208, Spain
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Ecogene-21
Chicoutimi, Quebec, G7H 5H6, Canada
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Erasmus MC
Rotterdam, 3015 G, Netherlands
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Excel Medical Clinical Trials, LLC
Boca Raton, Florida, 33434, United States
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Hospital Abente y Lago
A Coruña, Galicia, 15001, Spain
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Hospital Sant Joan de Deu
Barcelona, 8950, Spain
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Hospital Universitario 12 de Octubre
Madrid, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Reina Sofia
Córdoba, 14004, Spain
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Hospital Universitario de Jerez de la Frontera
Cadiz, 11407, Spain
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Kinder- und Jugendkrankenhaus AUF DER BULT
Hanover, Germany
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McMaster University Medical Center
Hamilton, Ontario, L8N 3Z5, Canada
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Providere Research Inc
West Covina, California, 91790, United States
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Rigshospitalet
Copenhagen, 2100, Denmark
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Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet
Frankfurt am Main, Germany
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University of Alberta Hospital - Stollery Children's Hospital
Edmonton, Alberta, T6G 2B7, Canada
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University of Utah and Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Viborg Regional Hospital
Viborg, Denmark
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Washington University School of Medicine, Division of Endocrinology, Metabolism and Lipid Research
St Louis, Missouri, 63110, United States
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