Bread that fights cholesterol? oat fiber put to the test
NCT ID NCT06822621
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This trial tests whether white bread enriched with oat beta-glucans can improve cholesterol levels and reduce inflammation in adults who are overweight or mildly hypercholesterolemic. Participants follow a calorie-restricted diet and eat either the enriched bread or a regular white bread daily for 8 weeks. Researchers will compare changes in blood cholesterol and inflammatory markers, as well as gut bacteria composition, between the two groups.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- White wheat bread enriched with oat beta-glucans
- What this could lead to
- If effective, this bread could offer a simple dietary way to help manage cholesterol and reduce inflammation in people with overweight or obesity.
- What could go wrong
- This is a small, early-stage trial, and the benefits may be modest or not appear. The bread is tested alongside a weight-loss diet, so any effect may be partly due to the diet itself.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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Sep 2024
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
25 to 60 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * no underlying diseases * with LDL-cholesterol levels between 115-150 mg/dL * with 25\<BMI\<32 kg/m2 * with stable body weight in the last 3 months before the intervention * with normal diet and exercise habits Exclusion Criteria: * not suffer from diabetes mellitus, cardiovascular disease, chronic renal failure * not receive hypolipidemic treatment * not receive nutritional supplements that may affect blood lipid levels (eg omega-3 supplements, plant sterols/stanols) or the intestinal microbial flora (probiotics/prebiotics/antibiotics). * not be pregnant or lactating * not have food allergies * not have habits that prevent their compliance with the research protocol
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National and Kapodistrian University of Athens, School of Medicine
Athens, Attica, 11527, Greece
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