OVERWEIGHT , OBESITY

This study tests whether a daily supplement of Akkermansia muciniphila (AKM Lab-01), a type of gut bacteria, can help overweight or obese adults lose weight safely. Two hundred participants will take either the supplement or a placebo for 3 months. Researchers will measure change…

This early-stage trial tests a single dose of the experimental drug IBIO-600 in 32 overweight or obese adults. The main goal is to see if the drug is safe and tolerable, and to measure how it moves through the body. Researchers will also look at its effect on body composition. Th…

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. The goal is to see if 12 weeks of treatment can improve how the body uses insulin, compared to a placebo. All participants also receive standard lifestyle advice. The …

This study looks at whether a community program that teaches families about healthy eating, physical activity, and sleep can help children who are overweight or obese. About 160 children will be randomly assigned to either join the program right away or be placed on a waitlist. T…

This study looks at whether drinking cranberry juice for 12 weeks can help overweight or obese adults improve blood sugar, insulin levels, cholesterol, and gut health. About 73 participants will be randomly assigned to receive either a cranberry drink or a placebo, then switch af…

This study tests whether a high-phenolic olive oil can improve metabolic health better than a low-phenolic version. Over 8 weeks, 80 adults with overweight/obesity and metabolic issues will consume one of the two oils. Researchers will measure changes in blood fats, blood pressur…

This study compares two versions of an experimental injection called BGM0504 to see if they work the same way in the body. It involves 144 overweight or obese adults aged 18-55. Participants receive a single dose, and researchers measure drug levels and monitor for side effects.

This study tests whether asiaticoside, a compound from the herb Centella asiatica, can help overweight or obese adults lose weight. Thirty participants will take asiaticoside tablets for 12 weeks, and researchers will measure changes in metabolic rate and body weight. The goal is…

This study is testing whether wearing a smartwatch and getting personalized health coaching through a mobile app can help people with high blood pressure, diabetes, obesity, or related conditions improve their lifestyle. About 1,700 adults aged 21-75 will wear a smartwatch for at…

This study tests whether a smartwatch-based program, combined with coaching from healthcare staff, can improve heart health in overweight or obese adults who have early signs of problems like high blood pressure or prediabetes. The program focuses on exercise and diet, and tracks…

This study looks at whether standing on a whole-body vibration machine can immediately improve blood pressure, heart rate, and walking ability in overweight or obese young women. 26 sedentary women aged 18-25 with a BMI between 25 and 40 will be recruited. The goal is to see if t…

This observational study will follow 10,000 adults with obesity or overweight to understand how the disease progresses and what factors predict treatment success. Researchers will analyze medical records from 2000 onward, looking at heart and metabolic complications over 5 to 10 …

This early-stage study looks at how ZT002, a long-acting experimental drug for weight management, affects the way the body processes four common medications (metformin, warfarin, rosuvastatin, and digoxin). About 60 overweight or obese but otherwise healthy adults aged 18-45 will…

This study compares how natural sugar (sucrose) and the artificial sweetener sucralose affect blood sugar control and metabolism in 120 adults with normal weight, overweight, or obesity. Participants will consume low or high doses of each sweetener in solid or liquid form over 12…

This study is testing a 24-week program that combines nutrition counseling, exercise, sleep tips, and stress management for cancer survivors who are overweight. Researchers want to see if the program is practical and helpful for improving sleep quality, reducing stress, and boost…

This early-stage study tests a single dose of Zovaglutide (ZT002), an experimental drug for overweight and obesity, in 40 adults with varying levels of kidney function. Researchers will measure how the drug moves through the body and check for side effects. The goal is to underst…

This study looks at how different snacks (walnuts or pretzels) change brain activity related to food cravings and fullness during a 12-week weight-loss diet. Researchers will use brain scans to measure responses to food pictures and track changes in body fat and appetite. The goa…