Sugar vs. sweetener showdown: which is better for your blood sugar?

NCT ID NCT07656298

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares how natural sugar (sucrose) and the artificial sweetener sucralose affect blood sugar control and metabolism in 120 adults with normal weight, overweight, or obesity. Participants will consume low or high doses of each sweetener in solid or liquid form over 12-week periods. The goal is to see if responses differ by body weight, dose, or how the sweetener is consumed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
sucrose (natural sugar) and sucralose (artificial sweetener)
What this could lead to
If successful, this could clarify whether artificial sweeteners are better or worse for metabolism than natural sugar, and how dose and form (solid vs. liquid) matter.
What could go wrong
This is an early-stage observational study with only 120 participants, so results may not apply to everyone. It measures short-term effects, not long-term health outcomes.

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Conditions

The condition(s) this trial relates to.

glucose metabolism disease Inflammation Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hospital Universitario Virgen de la Victoria

    RECRUITING

    Málaga, Malaga, 29103, Spain

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