OVERWEIGHT , OBESITY

This study is testing whether a daily supplement containing a specific gut bacteria (Akkermansia muciniphila) can help people who are overweight or obese lose weight and improve related health markers like cholesterol and blood sugar. About 200 participants will take either the s…

This study is testing whether an investigational drug called Zovaglutide can help adults with overweight or obesity lose weight and keep it off. About 744 participants will receive either Zovaglutide or a placebo (a dummy treatment) for 52 weeks to see how much weight they lose a…

This study aims to test a new screening tool to spot binge eating disorder early in children and teens aged 7-14. It will also see if a 10-week summer camp program, with or without extra help for parents, can reduce binge eating behaviors. The goal is to find better ways to ident…

This study is testing an existing program that teaches families of children with overweight or obesity about healthy eating and physical activity. About 160 children, aged 6-14, will be randomly assigned to start the program right away or wait three months. Researchers will measu…

This study is testing whether a supervised, community-based exercise program can help older adults with multiple chronic conditions improve their health and quality of life. It will enroll 150 people aged 50 and older who have at least two conditions like heart disease risk, diab…

This study is testing whether a new tablet called ZT006 helps people with overweight or obesity lose weight. About 180 participants will take either ZT006 or a placebo (a dummy pill) for 28 weeks, while also following a diet and exercise plan. The main goal is to see how much bod…

This study is testing whether a program using smartwatches, a phone app, and health coaching can help overweight adults improve their heart health. It will involve about 1,400 people who have borderline high blood pressure, blood sugar, or cholesterol. The goal is to see if this …

This study is testing whether a family-based health program can slow down the start of puberty in girls who are overweight. Researchers will enroll 240 girls from lower-income families. Half will receive a 5-month program focused on healthy eating and activity, while the other ha…

This study is testing a new type of school physical education class designed to prevent several common health issues in teenagers at the same time. The program combines exercise with health education and will be tested on 200 junior high school students in China. Researchers want…

This small pilot study is testing whether a combined nutrition and exercise program is practical and helpful for cancer survivors who have finished treatment and are overweight. The 6-month program includes education, counseling, group support, and using wearable devices to track…

This study aims to learn if exercising at a specific time of day—morning or evening—works better for improving how the body handles sugar in adults with prediabetes who have extreme natural body clocks (early 'larks' or late 'owls'). Researchers will compare no exercise, morning …

This study aims to understand how the level of food processing affects health markers like blood pressure, blood sugar, and cholesterol. Researchers will provide 79 overweight or obese adults with two different diets that both follow healthy eating guidelines—one made mostly of u…

This is an early safety study for a new injectable drug called ZT002, being developed for overweight and obesity. It aims to understand how the drug is processed by the body in 40 people with different levels of kidney function, compared to people with normal kidneys. The main go…

This study aims to understand how eating different daily snacks (walnuts or pretzels) affects brain activity related to food and feelings of fullness during a 12-week weight-loss program. Researchers will use brain scans and questionnaires to measure changes in cravings, appetite…

This study aims to understand how a 12-week exercise program changes brain activity in response to food pictures and stress in inactive, overweight veterans. Researchers will use brain scans and hormone tests to see if exercise alters how the brain processes food cues and stress.…