OVERWEIGHT , OBESITY

This early-stage study tests a new drug, SRSD384, to see if it is safe and how it works in people who are overweight or obese. The study has two parts: one tests the drug alone, and the other tests it together with another weight loss drug, tirzepatide, in people who also have ty…

This study tests if a family-based weight management program can slow the start of puberty in 240 overweight girls aged 6.5 to 8 from low-income households. Half the families will attend 20 weekly sessions on healthy eating and activity, while the other half receive usual care an…

This study tests a new drug, zovaglutide, to help adults with overweight or obesity lose weight. About 744 people will receive either the drug or a placebo for 52 weeks. The main goal is to see how much weight they lose and if at least 5% of body weight is lost.

This early-stage study tests a single dose of the experimental drug IBIO-600 in 32 overweight or obese adults aged 18 to 65. The main goal is to find a safe and tolerable dose while checking how the drug affects body composition. Participants must have a stable weight and no majo…

This study tests whether a smart lifestyle program that combines diet and exercise can improve metabolic health in 435 overweight or obese adults aged 20-60 with metabolic syndrome. Participants will be split into two groups: one receiving simple dietary advice, and the other rec…

This study tests a community-based exercise program for adults aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, or arthritis. The goal is to see if personalized exercise can improve heart and muscle fitness, mobility, and overall well-b…

This study tests whether adding metformin (a diabetes drug) to secukinumab (a standard psoriasis medication) works better than secukinumab alone for treating moderate-to-severe plaque psoriasis in overweight or obese Chinese adults. About 186 participants will receive either the …

This study tests whether a daily probiotic called AKM Lab-01 can help overweight or obese adults lose weight safely. About 200 participants will take either the probiotic or a placebo for 3 months. Researchers will measure changes in body weight, BMI, blood fats, blood sugar, and…

This study tests a new physical education program designed to prevent common health issues like myopia, overweight, and anxiety in 200 junior high students. The program combines exercise with health education, aiming to address multiple conditions at once. Researchers will compar…

This study tests whether a 10-week camp program can help children and teens (ages 7-14) who struggle with binge eating. Some parents will also receive special training to support their child. Researchers will follow participants for up to five years to see if the program reduces …

This early-stage study looks at whether ZT002, a new long-acting drug for weight management, changes how the body processes four common medications (metformin, warfarin, rosuvastatin, and digoxin). About 60 healthy overweight or obese adults aged 18–45 will take these drugs with …

This study looks at whether exercising in the morning or evening improves how the body handles sugar in people with prediabetes who have an extreme natural body clock. Twenty-eight overweight adults will try no exercise, morning exercise, and evening exercise on separate days. Th…

This study looks at whether a single session of magnetic brain stimulation can temporarily change how the heart and brain communicate in women who have had multiple pregnancy losses and are overweight or obese. Sixty women will be randomly assigned to receive either real or fake …

This study will check how much weight people lose after six months on tirzepatide combined with lifestyle coaching in real-world Dutch clinics. Researchers will look at medical records of 1700 adults with obesity (BMI 30+ or 27+ with related health issues) who haven't had prior o…

This study looks at how eating mostly ultra-processed foods versus less-processed foods changes key health markers like blood pressure, blood sugar, and cholesterol. About 79 overweight adults will follow special diets based on dietary guidelines. The goal is to understand how fo…

This study looks at how exercise changes the way the brain reacts to stress and food in overweight veterans. Researchers will use brain scans and hormone tests to understand these effects. The goal is to learn more about stress-related eating, not to test a new treatment.