Genetic test aims to get vets on statins and cut heart risk

NCT ID NCT06568601

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their statin response and heart risk, or a standard risk report. The goal is to see if personalized genetic information improves cholesterol levels over 15 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pharmacogenetic and polygenic risk testing
What this could lead to: If successful, this approach could help more veterans lower their cholesterol and reduce heart disease risk by personalizing statin therapy.
What could go wrong: This is a relatively small, early-stage study (410 participants) and focuses on behavior change, not a new drug. Results may not apply to non-veterans or those already on statins.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder diabetes mellitus Genetic Risk Score Hypercholesterolemia hyperlipidemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERCHOLESTEROLEMIA

Contacts and locations

Locations

Durham VA Medical Center, Durham, NC
NOT_YET_RECRUITING

Durham, North Carolina, 27705-3875, United States
Richard L. Roudebush VA Medical Center, Indianapolis, IN
RECRUITING

Indianapolis, Indiana, 46202-2884, United States

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