HYPERCHOLESTEROLEMIA

This completed Phase 3 trial tested two new drugs, AG2304T and AG2304R, in 158 adults with primary hypercholesterolemia (high cholesterol). The study compared these drugs to an active control to see how well they lower LDL cholesterol and to check for side effects. Results could …

This early-stage study tested a new drug called BKR-017 in 9 adults already taking statins for high cholesterol. Researchers checked how the body handles BKR-017 and whether it builds up over a week of twice-daily dosing. The main goal was to see if it is safe and how it affects …

This study tested the drug pravastatin in 21 HIV-positive people with high cholesterol who were already on HIV medications. The goal was to see if pravastatin could safely lower their cholesterol without affecting their HIV treatment. Participants received either pravastatin or a…

This study tested whether drinking a calcium-bicarbonate mineral water called Lete can lower LDL (bad) cholesterol in healthy adults with high cholesterol. 160 participants drank either the test water or a regular low-mineral water for four months. The goal was to see if the mine…

This completed Phase 3 trial tested whether a single pill combining ezetimibe, rosuvastatin, and amlodipine can safely lower both cholesterol and blood pressure in 163 Korean adults with hypertension and high cholesterol. Participants took the combination pill or a control for 8 …

This completed Phase 4 trial tested the drug inclisiran (given as a shot under the skin) against a placebo in 1770 adults with high cholesterol who were already on cholesterol-lowering therapy. The goal was to see if inclisiran helps more people reach their LDL cholesterol target…

This study tested whether drinking unsweetened soymilk every day can lower cholesterol in adults with high levels. Twenty-five participants drank two bottles (750 mL total) daily for 8 weeks. Researchers measured cholesterol and other health markers to see if the soymilk helped i…

This study tested a new drug called MK-0616 (enlicitide) to see if it lowers 'bad' LDL cholesterol better than current pills (ezetimibe, bempedoic acid, or both). About 300 adults with high cholesterol and heart disease risk took part. The main goal was to check cholesterol reduc…

This study looked at how well the drug atostazet lowers cholesterol and affects blood sugar in people aged 65 and older with high cholesterol. Over 600 participants took the drug for 6 months, and researchers tracked side effects and changes in glucose metabolism. The goal was to…

This study looked at how a red yeast rice supplement (LipoCol Forte) affects cholesterol in 41 men aged 35-55 with high cholesterol. Researchers checked blood and stool samples to see changes in cholesterol, heart disease risk, gut bacteria, and bile acids. The goal was to see if…

This completed study looked at nearly 7,000 adults with high cholesterol who switched from taking a statin alone to a combination pill containing Pitavastatin and Ezetimibe. The main goal was to see how much their LDL (bad) cholesterol dropped after 24 weeks. The study was observ…

This Phase 3 trial tested an oral drug called enlicitide decanoate (MK-0616) in 303 adults with heterozygous familial hypercholesterolemia, an inherited condition causing very high cholesterol. Participants took either the drug or a placebo daily for up to 52 weeks. The main goal…

This study looked at how well the drug Livalozet lowers bad cholesterol (LDL-C) in people with high cholesterol, comparing those with and without diabetes. Over 1,500 adults took part for 24 weeks. The main goal was to measure the change in LDL-C levels from the start of the stud…

This study tested whether a twice-yearly injection (inclisiran) lowers LDL cholesterol better than a daily pill (bempedoic acid) in 402 adults with heart disease who still have high cholesterol despite taking statins. Participants received either inclisiran or bempedoic acid on t…

This study tested a drug called pemafibrate (K-877) in 71 people with high cholesterol who cannot take statins due to side effects. Participants took either a low or high dose of pemafibrate or a placebo daily for 12 weeks. The goal was to see if pemafibrate safely lowers LDL (ba…

This study looked at whether eating sunflower seeds every day can lower cholesterol in adults. 28 men with high cholesterol ate a set amount of sunflower seeds for 45 days. Their cholesterol levels were checked before and after. The goal is to see if sunflower seeds can be a simp…

This study tested a new medicine called inclisiran in 350 people with high cholesterol who were not taking any other cholesterol drugs. The goal was to see if inclisiran could lower 'bad' LDL cholesterol more than a placebo or another drug called ezetimibe. Participants received …

This Phase 3 trial tested a daily pill combining two drugs, obicetrapib and ezetimibe, in 407 people with inherited high cholesterol or heart disease. Participants took the combination or a placebo on top of their usual cholesterol meds. The main goal was to see if the combo lowe…

This Phase 3 trial tested whether a single pill combining ezetimibe and rosuvastatin works better than rosuvastatin alone for lowering LDL (bad) cholesterol. The study included 305 Chinese adults whose cholesterol was not well controlled on statin therapy. Participants took eithe…

This study tested a new drug called obicetrapib in over 2,500 people with high cholesterol that wasn't well controlled by their current treatments. Participants took either a 10 mg obicetrapib pill or a placebo daily for about 6 months. The main goal was to see if obicetrapib cou…

This large Phase 3 trial tested an experimental oral drug called enlicitide decanoate (MK-0616) in nearly 3,000 adults with high cholesterol, including those with a genetic form. The goal was to see if the drug safely lowers 'bad' LDL cholesterol more than a placebo over 24 weeks…

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This study tested whether an educational website helps people who stopped taking statins due to muscle pain make informed decisions about restarting. Nearly 900 participants were randomly assigned to use the website or receive usual care. The goal was to see if the website increa…

This completed study followed 1868 patients with high cholesterol to see how inclisiran (Leqvio®) and other cholesterol-lowering treatments work in real-world medical practice. Researchers tracked heart events, medication use, and lab results without assigning any treatments. The…

This study looked at medical records from over 11,900 adults in China who took either inclisiran or PCSK9 mAbs to lower their high cholesterol. Researchers wanted to see how well these drugs worked in everyday medical practice, not just in controlled trials. The study found that …