New drug offers hope for Statin-Intolerant patients with high cholesterol
NCT ID NCT05923281
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called pemafibrate (K-877) in 71 people with high cholesterol who cannot take statins due to side effects. Participants took either a low or high dose of pemafibrate or a placebo daily for 12 weeks. The goal was to see if pemafibrate safely lowers LDL (bad) cholesterol.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pemafibrate (K-877)
What this could lead to
If it works, this could provide a new treatment option for people with high cholesterol who cannot tolerate statins.
What could go wrong
This is a small, completed Phase 3 trial with only 71 participants. The results may not apply to everyone, and pemafibrate may not lower cholesterol as effectively as statins.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Affiliated CENTRAL CLINIC of Higashiyamato Hospital
Tokyo, Japan
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Central Japan International Medical Center
Gifu, Japan
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Fukuwa Clinic
Tokyo, Japan
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Juntendo University Hospital
Tokyo, Japan
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Kohnodai Hospital, National Center for Global Health and Medicine
Chiba, Japan
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Koshigaya Municipal Hospital
Saitama, Japan
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Kumamoto University Hospital
Kumamoto, Japan
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Medical Corporation Chiseikai Tokyo Center Clinic
Tokyo, Japan
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Medical Corporation LONGWOOD Maeda Clinic
Osaka, Japan
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Mishuku Hospital
Tokyo, Japan
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NTT Medical Center Sapporo
Hokkaido, Japan
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Nakayama Clinic
Aichi, Japan
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OCROM Clinic
Osaka, Japan
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Rinku General Medical Center
Osaka, Japan
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Saitama Medical University Hospital
Saitama, Japan
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Seiwa Clinic
Tokyo, Japan
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Tashiro Endocrinology Clinic
Fukuoka, Japan
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ToCROM Clinic
Tokyo, Japan
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Tokyo Heart Summit Tokyo Heart Rhythm Hospital
Tokyo, Japan
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Tokyo-Eki Center-building Clinic
Tokyo, Japan
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Tsukuba Medical Center Foundation Tsukuba Medical Center Hospital
Ibaraki, Japan
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Yokohama Minami Kyosai Hospital
Kanagawa, Japan