New shot shows promise for lowering bad cholesterol

NCT ID NCT05763875

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new medicine called inclisiran in 350 people with high cholesterol who were not taking any other cholesterol drugs. The goal was to see if inclisiran could lower 'bad' LDL cholesterol more than a placebo or another drug called ezetimibe. Participants received either inclisiran, ezetimibe, or a placebo, and their cholesterol levels were measured after 150 days.

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Conditions

The condition(s) this trial relates to.

Hypercholesterolemia hyperlipidemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERCHOLESTEROLEMIA

Contacts and locations

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Locations

Alma Clinical Research Inc

Miami, Florida, 33165, United States
ClinCloud

Maitland, Florida, 32751, United States
Compass Point Research

Nashville, Tennessee, 37203, United States
Conrad Clinical Research

Edmond, Oklahoma, 73013, United States
Cozy Research LLC

Zephyrhills, Florida, 33541, United States
Dominion Medical Associates

Richmond, Virginia, 23219, United States
Fam Medical Specialists Of Fl Plc

Plant City, Florida, 33563, United States
Grace Research LLC

Bossier City, Louisiana, 71111, United States
Grace Research Llc

Shreveport, Louisiana, 71101, United States
Harmony Clinical Research

North Miami Beach, Florida, 33162, United States
Hillcrest Medical Research

DeLand, Florida, 32720, United States
Inpatient Research Clinical LLC

Miami Lakes, Florida, 33014, United States
Koch Family Medicine

Morton, Illinois, 61550, United States
Lillestol Research LLC

Fargo, North Dakota, 58103, United States
Monroe Biomedical Research

Monroe, North Carolina, 28112, United States
Mt Olympus Medical Research

Sugar Land, Texas, 77479, United States
Novartis Investigative Site

Barranquilla, Atlántico, 080012, Colombia
Novartis Investigative Site

Floridablanca, Santander Department, 57-7, Colombia
Novartis Investigative Site

Manizales, 170008, Colombia
Novartis Investigative Site

San Gil, 684031, Colombia
Novartis Investigative Site

Munich, Bavaria, 80809, Germany
Novartis Investigative Site

Hanover, Lower Saxony, 30449, Germany
Novartis Investigative Site

Löhne, North Rhine-Westphalia, 32584, Germany
Novartis Investigative Site

Jerichow, Saxony-Anhalt, 39319, Germany
Novartis Investigative Site

Berlin, 10787, Germany
Novartis Investigative Site

Bochum, 44789, Germany
Novartis Investigative Site

Gladbeck, 45968, Germany
Novartis Investigative Site

Hamburg, 22607, Germany
Novartis Investigative Site

Papenburg, 26871, Germany
Novartis Investigative Site

Budapest, 1083, Hungary
Novartis Investigative Site

Pécs, 7623, Hungary
Novartis Investigative Site

Monterrey, Nuevo León, 64060, Mexico
Novartis Investigative Site

Monterrey, Nuevo León, 64440, Mexico
Novartis Investigative Site

Mérida, Yucatán, 97070, Mexico
Novartis Investigative Site

Culiacan Sinaloa, 80230, Mexico
Novartis Investigative Site

Querétaro, 76000, Mexico
Parkway Medical Center

Birmingham, Alabama, 35215, United States
Prime Global Research Inc

The Bronx, New York, 10456, United States
SEC Clinical Research

Dothan, Alabama, 36305, United States
Southern Clin Research Clinic

Zachary, Louisiana, 70791, United States
Spaulding Clinical Research

West Bend, Wisconsin, 53095, United States
WellNow Urgent Care and Research

Huber Heights, Ohio, 45424, United States

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