New cholesterol shot shows promise in large trial

NCT ID NCT05192941

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 4 trial tested the drug inclisiran (given as a shot under the skin) against a placebo in 1770 adults with high cholesterol who were already on cholesterol-lowering therapy. The goal was to see if inclisiran helps more people reach their LDL cholesterol targets. The study also looked at safety and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inclisiran (a drug injected under the skin to lower cholesterol)
What this could lead to: If it works, this could provide a new, convenient treatment option for people with high cholesterol who need to lower their heart disease risk.
What could go wrong: This is a completed Phase 4 trial, so results are known. However, inclisiran may not work for everyone, and side effects like muscle pain are possible. It is not a cure, just a way to manage cholesterol.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris cardiovascular disorder Dyslipidemias Hypercholesterolemia hyperlipidemia peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERCHOLESTEROLEMIA

Contacts and locations

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Locations

Novartis Investigative Site

Sofia, Bulgaria, 1202, Bulgaria
Novartis Investigative Site

Burgas, Burgas, 8000, Bulgaria
Novartis Investigative Site

Burgas, 8001, Bulgaria
Novartis Investigative Site

Gabrovo, 5300, Bulgaria
Novartis Investigative Site

Pleven, 5800, Bulgaria
Novartis Investigative Site

Plovdiv, 4002, Bulgaria
Novartis Investigative Site

Rousse, 7000, Bulgaria
Novartis Investigative Site

Sofia, 1233, Bulgaria
Novartis Investigative Site

Sofia, 1606, Bulgaria
Novartis Investigative Site

Sofia, 1618, Bulgaria
Novartis Investigative Site

Stara Zagora, 6000, Bulgaria
Novartis Investigative Site

Varna, 9010, Bulgaria
Novartis Investigative Site

Veliko Tarnovo, 5000, Bulgaria
Novartis Investigative Site

Chlumec nad Cidlinou, Chlumec Nad Cidlinou, 503 51, Czechia
Novartis Investigative Site

Přerov, Olomouc Region, 750 02, Czechia
Novartis Investigative Site

Hlučín, 748 01, Czechia
Novartis Investigative Site

Hodonín, 695 01, Czechia
Novartis Investigative Site

Mělník, 276 01, Czechia
Novartis Investigative Site

Olomouc, 772 00, Czechia
Novartis Investigative Site

Olomouc, 779 00, Czechia
Novartis Investigative Site

Pardubice, 532 03, Czechia
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Slaný, 274 01, Czechia
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Trutnov, 460 63, Czechia
Novartis Investigative Site

Pärnu, 80018, Estonia
Novartis Investigative Site

Tallinn, 10138, Estonia
Novartis Investigative Site

Tallinn, 13419, Estonia
Novartis Investigative Site

Tartu, 50406, Estonia
Novartis Investigative Site

Amiens, 80054, France
Novartis Investigative Site

Chambéry, 73000, France
Novartis Investigative Site

Le Chesnay, 78150, France
Novartis Investigative Site

Le Kremlin-Bicêtre, 94275, France
Novartis Investigative Site

Lille, 59000, France
Novartis Investigative Site

Marseille, 13005, France
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Nantes, 44093, France
Novartis Investigative Site

Paris, 75013, France
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Valenciennes, 59300, France
Novartis Investigative Site

Mannheim, Baden-Wurttemberg, 68305, Germany
Novartis Investigative Site

Stuttgart, Baden-Wurttemberg, 70376, Germany
Novartis Investigative Site

Lichtenfels, Bavaria, 96215, Germany
Novartis Investigative Site

Muehldorf Am Inn, Bavaria, 84453, Germany
Novartis Investigative Site

Munich, Bavaria, 81377, Germany
Novartis Investigative Site

Nuremberg, Bavaria, 90402, Germany
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Regensburg, Bavaria, 93053, Germany
Novartis Investigative Site

Frankfurt am Main, Hesse, 60590, Germany
Novartis Investigative Site

Frankfurt am Main, Hesse, 60594, Germany
Novartis Investigative Site

Frankfurt am Main, Hesse, 65929, Germany
Novartis Investigative Site

Langen, Hesse, 63225, Germany
Novartis Investigative Site

Göttingen, Lower Saxony, 37075, Germany
Novartis Investigative Site

Hanover, Lower Saxony, 30159, Germany
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Hanover, Lower Saxony, 30449, Germany
Novartis Investigative Site

Winsen, Lower Saxony, 21423, Germany
Novartis Investigative Site

Cologne, North Rhine-Westphalia, 51065, Germany
Novartis Investigative Site

Essen, North Rhine-Westphalia, 45355, Germany
Novartis Investigative Site

Löhne, North Rhine-Westphalia, 32584, Germany
Novartis Investigative Site

Kaiserslautern, Rhineland-Palatinate, 67655, Germany
Novartis Investigative Site

Saint Ingbert, Saarland, 66386, Germany
Novartis Investigative Site

Bad Gottleuba, Saxony, 01816, Germany
Novartis Investigative Site

Dresden, Saxony, 01099, Germany
Novartis Investigative Site

Dresden, Saxony, 01307, Germany
Novartis Investigative Site

Leipzig, Saxony, 04103, Germany
Novartis Investigative Site

Schleswig, Schleswig-Holstein, 24837, Germany
Novartis Investigative Site

Bad Homburg, 61348, Germany
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Bad Krozingen, 79189, Germany
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Bad Oeynhausen, 32545, Germany
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Bamberg, 96049, Germany
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Berlin, 10367, Germany
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Berlin, 10559, Germany
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Berlin, 10787, Germany
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Berlin, 10789, Germany
Novartis Investigative Site

Berlin, 13347, Germany
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Berlin, 13353, Germany
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Bochum, 44789, Germany
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Bremen, 28277, Germany
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Coburg, 96450, Germany
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Cologne, 51069, Germany
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Dessau, 06846, Germany
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Dresden, 01307, Germany
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Duisburg, 47051, Germany
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Erfurt, 99089, Germany
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Erfurt, 99097, Germany
Novartis Investigative Site

Essen, 45277, Germany
Novartis Investigative Site

Essen, 45355, Germany
Novartis Investigative Site

Essen, 45359, Germany
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Fulda, 36037, Germany
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Gelnhausen, 63571, Germany
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Gladbeck, 45968, Germany
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Hamburg, 22041, Germany
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Hamburg, 22607, Germany
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Haßloch, 67454, Germany
Novartis Investigative Site

Hennigsdorf, 16761, Germany
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Hoyerswerda, 02977, Germany
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Kassel, 34121, Germany
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Kiel, 24105, Germany
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Lüneburg, 21339, Germany
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Magdeburg, 39110, Germany
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Magdeburg, 39120, Germany
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Mainz, 55131, Germany
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Mannheim, 68165, Germany
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Markkleeberg, 04416, Germany
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Münster, 48149, Germany
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Papenburg, 26871, Germany
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Pirna, 01796, Germany
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Potsdam, 14471, Germany
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Reinfeld, 23858, Germany
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Rostock, 18057, Germany
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Rüdersdorf, 15562, Germany
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Singen, 78224, Germany
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Stuttgart, 70378, Germany
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Wallerfing, 94574, Germany
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Warendorf, 48231, Germany
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Wuppertal, 42117, Germany
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Daugavpils, LV-5417, Latvia
Novartis Investigative Site

Ogre, 5001, Latvia
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Riga, 1012, Latvia
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Riga, LV 1002, Latvia
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Riga, LV-1001, Latvia
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Riga, LV-1012, Latvia
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Krosno, Krosno, 38-400, Poland
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Krakow, Maloposkie, 31-271, Poland
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Szczecin, West Pomeranian Voivodeship, 71-528, Poland
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Gdynia, 81-157, Poland
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Katowice, 40-648, Poland
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Krakow, 31-216, Poland
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Rzeszów, 35-055, Poland
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Skierniewice, 96-100, Poland
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Tarnów, 33-100, Poland
Novartis Investigative Site

Málaga, Andalusia, 29009, Spain
Novartis Investigative Site

Seville, Andalusia, 41014, Spain
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Sanlucar Barrameda, Cadiz, 11540, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08003, Spain
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Majadahonda, Madrid, 28222, Spain
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San Sebastian Reyes, Madrid, 28702, Spain
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Oviedo, Principality of Asturias, 33011, Spain
Novartis Investigative Site

Barcelona, 08035, Spain
Novartis Investigative Site

Córdoba, 14004, Spain
Novartis Investigative Site

Seville, 41013, Spain

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