New combo pill slashes stubborn cholesterol in High-Risk patients
NCT ID NCT06005597
First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 18 times
Summary
This phase 3 study tested a daily pill that combines two drugs, obicetrapib and ezetimibe, in 407 adults with inherited high cholesterol or heart disease. Participants were already on maximum cholesterol-lowering therapy. The goal was to see if the combo pill could further lower LDL (bad) cholesterol more than either drug alone or a placebo. The study is complete, and results will show if this new option can help control cholesterol levels better.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alpine Research Organization, Inc.
Clinton, Utah, 84015, United States
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Amarillo Heart Clinical Research Institute, Inc
Amarillo, Texas, 79124, United States
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Capital Area Research
Camp Hill, Pennsylvania, 17074, United States
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Cardiovascular Research of Knoxville
Powell, Tennessee, 37849, United States
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Cardiovascular Research of Northwest Indiana, LLC
Munster, Indiana, 46321, United States
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Cary Research Group, LLC
Cary, North Carolina, 27518, United States
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Center for Advanced Research and Education
Gainesville, Georgia, 30501, United States
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CentraCare Heart & Vascular Center
Saint Cloud, Minnesota, 56303, United States
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Centricity Research - Columbus
Columbus, Georgia, 31904, United States
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Chattanooga Research & Medicine, PLLC
Chattanooga, Tennessee, 37404, United States
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DM Clinical Research
Houston, Texas, 77375, United States
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Diabetes and Thyroid Center of Fort Worth
Fort Worth, Texas, 76132, United States
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East Valley Diabetes & Endocrinology
Gilbert, Arizona, 85297, United States
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Evanston Premier Healthcare Research LLC
Skokie, Illinois, 60077, United States
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Grace Research, LLC - Bossier City, LA
Bossier City, Louisiana, 71111, United States
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Hampton Roads Center for Clinical Research
Suffolk, Virginia, 23435, United States
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Horizon Research Group of Opelousas
Eunice, Louisiana, 70535, United States
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Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
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Juno Research, LLC - Medical Center Office
Houston, Texas, 77054, United States
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Lucas Research, Inc
Morehead City, North Carolina, 28557, United States
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Maryland Cardiovascular Specialists
Baltimore, Maryland, 21229, United States
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McClaren Bay Heart and Vascular
Bay City, Michigan, 49770, United States
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Metabolic and Atherosclerosis Research Center
Cincinnati, Ohio, 45227, United States
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Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc
Rapid City, South Dakota, 57701, United States
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NSC Research
Johns Creek, Georgia, 30024, United States
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North Georgia Clinical Research
Woodstock, Georgia, 30189, United States
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North Mississippi Medical Center
Tupelo, Mississippi, 38801, United States
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Northern Pines Health Center
Buckley, Michigan, 49620, United States
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Northwest Houston Heart Center
Tomball, Texas, 77375, United States
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Novant Health Clinical Research, LLC
Charlotte, North Carolina, 27701, United States
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Novant Health Heart and Vascular Institute
Charlotte, North Carolina, 28204, United States
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Oakland Medical Research Center
Troy, Michigan, 48085, United States
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PharmaTex Research, LLC
Amarillo, Texas, 79109, United States
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Progressive Medical Research
Port Orange, Florida, 32127, United States
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South Texas Clinical Research
Corpus Christi, Texas, 78404, United States
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Sparrow Clinical Research Institute
Lansing, Michigan, 48912, United States
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Spectrum Medical, Inc.
Danville, Virginia, 24541, United States
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St. Louis Heart and Vascular Cardiology
St Louis, Missouri, 63136, United States
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Summit Research Group, LLC
Stow, Ohio, 44240, United States
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TidalHealth Peninsula Regional, Inc.
Salisbury, Maryland, 21804, United States
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Triad Internal Medicine
Asheboro, North Carolina, 27203, United States
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Washington University School of Medicine
St Louis, Missouri, 63136, United States
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Wellness Clinical Research Associates
McKinney, Texas, 75069, United States
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Wilmington Health Associates
Wilmington, North Carolina, 28412, United States
Conditions
Explore the condition pages connected to this study.