New daily pill aims to crush stubborn cholesterol in High-Risk patients
NCT ID NCT06005597
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tested a daily pill combining two drugs, obicetrapib and ezetimibe, in 407 people with inherited high cholesterol or heart disease. Participants took the combination or a placebo on top of their usual cholesterol meds. The main goal was to see if the combo lowered LDL ('bad') cholesterol more than placebo or either drug alone. Results are pending.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
obicetrapib and ezetimibe combination pill
What this could lead to
If successful, this combination pill could offer a new, more effective daily option to lower LDL cholesterol in people with stubborn high cholesterol, potentially reducing heart attack and stroke risk.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. The combination may cause side effects or not work better than existing treatments. Long-term safety and heart benefits are still unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alpine Research Organization, Inc.
Clinton, Utah, 84015, United States
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Amarillo Heart Clinical Research Institute, Inc
Amarillo, Texas, 79124, United States
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Capital Area Research
Camp Hill, Pennsylvania, 17074, United States
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Cardiovascular Research of Knoxville
Powell, Tennessee, 37849, United States
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Cardiovascular Research of Northwest Indiana, LLC
Munster, Indiana, 46321, United States
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Cary Research Group, LLC
Cary, North Carolina, 27518, United States
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Center for Advanced Research and Education
Gainesville, Georgia, 30501, United States
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CentraCare Heart & Vascular Center
Saint Cloud, Minnesota, 56303, United States
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Centricity Research - Columbus
Columbus, Georgia, 31904, United States
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Chattanooga Research & Medicine, PLLC
Chattanooga, Tennessee, 37404, United States
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DM Clinical Research
Houston, Texas, 77375, United States
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Diabetes and Thyroid Center of Fort Worth
Fort Worth, Texas, 76132, United States
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East Valley Diabetes & Endocrinology
Gilbert, Arizona, 85297, United States
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Evanston Premier Healthcare Research LLC
Skokie, Illinois, 60077, United States
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Grace Research, LLC - Bossier City, LA
Bossier City, Louisiana, 71111, United States
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Hampton Roads Center for Clinical Research
Suffolk, Virginia, 23435, United States
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Horizon Research Group of Opelousas
Eunice, Louisiana, 70535, United States
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Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
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Juno Research, LLC - Medical Center Office
Houston, Texas, 77054, United States
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Lucas Research, Inc
Morehead City, North Carolina, 28557, United States
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Maryland Cardiovascular Specialists
Baltimore, Maryland, 21229, United States
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McClaren Bay Heart and Vascular
Bay City, Michigan, 49770, United States
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Metabolic and Atherosclerosis Research Center
Cincinnati, Ohio, 45227, United States
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Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc
Rapid City, South Dakota, 57701, United States
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NSC Research
Johns Creek, Georgia, 30024, United States
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North Georgia Clinical Research
Woodstock, Georgia, 30189, United States
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North Mississippi Medical Center
Tupelo, Mississippi, 38801, United States
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Northern Pines Health Center
Buckley, Michigan, 49620, United States
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Northwest Houston Heart Center
Tomball, Texas, 77375, United States
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Novant Health Clinical Research, LLC
Charlotte, North Carolina, 27701, United States
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Novant Health Heart and Vascular Institute
Charlotte, North Carolina, 28204, United States
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Oakland Medical Research Center
Troy, Michigan, 48085, United States
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PharmaTex Research, LLC
Amarillo, Texas, 79109, United States
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Progressive Medical Research
Port Orange, Florida, 32127, United States
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South Texas Clinical Research
Corpus Christi, Texas, 78404, United States
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Sparrow Clinical Research Institute
Lansing, Michigan, 48912, United States
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Spectrum Medical, Inc.
Danville, Virginia, 24541, United States
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St. Louis Heart and Vascular Cardiology
St Louis, Missouri, 63136, United States
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Summit Research Group, LLC
Stow, Ohio, 44240, United States
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TidalHealth Peninsula Regional, Inc.
Salisbury, Maryland, 21804, United States
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Triad Internal Medicine
Asheboro, North Carolina, 27203, United States
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Washington University School of Medicine
St Louis, Missouri, 63136, United States
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Wellness Clinical Research Associates
McKinney, Texas, 75069, United States
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Wilmington Health Associates
Wilmington, North Carolina, 28412, United States