HYPERCHOLESTEROLEMIA
Clinical trials for HYPERCHOLESTEROLEMIA explained in plain language.
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New hope for stubborn high cholesterol: experimental drug SHR-1918 enters trials
Disease control Not yet recruitingThis study tests an experimental drug called SHR-1918 for people with high cholesterol that remains high despite taking statins and PCSK9 inhibitors. About 126 adults will receive either SHR-1918 or a placebo to see if the drug safely lowers cholesterol levels over 12 to 24 weeks…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: PHASE2, PHASE3 • Sponsor: Beijing Suncadia Pharmaceuticals Co., Ltd • Aim: Disease control
Last updated May 17, 2026 03:00 UTC
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New combo therapy could protect kidneys and hearts without High-Dose statins
Disease control Not yet recruitingThis study compares two cholesterol-lowering approaches in about 1,950 adults with chronic kidney disease and heart disease. One group gets a moderate statin plus ezetimibe, the other a high-dose statin alone. The goal is to see if the combination is as good at preventing heart a…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: NA • Sponsor: Yonsei University • Aim: Disease control
Last updated May 17, 2026 02:57 UTC
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Triple therapy aims to melt artery plaque before first heart attack
Disease control Not yet recruitingThis study tests whether a combination of three cholesterol-lowering medicines (bempedoic acid, ezetimibe, and a high-intensity statin) can reduce and stabilize plaque buildup in the coronary arteries. It includes 103 adults with early atherosclerosis who have never had a heart a…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: PHASE3 • Sponsor: Daiichi Sankyo • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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Double-Barreled cholesterol attack: new combo trial for Statin-Intolerant patients
Disease control Not yet recruitingThis study tests whether combining two cholesterol-lowering drugs (inclisiran and alirocumab) works better than either drug alone. About 60 adults with high heart risk who cannot take statins will receive one or both drugs for 9 months. The goal is to see if the combo lowers 'bad…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: PHASE4 • Sponsor: University Medical Centre Ljubljana • Aim: Disease control
Last updated May 13, 2026 16:01 UTC
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Heart-Healthy drugs may shield brain in At-Risk group
Disease control Not yet recruitingThis small pilot study will test whether a pharmacist-led program to manage high blood pressure and high cholesterol can help protect brain health in 10 people aged 50-75 who carry the APOE ε4 gene, a known risk factor for dementia. Participants will take standard medications (AR…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: PHASE2 • Sponsor: University of Southern California • Aim: Disease control
Last updated May 07, 2026 18:41 UTC
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Triple drug attack on cholesterol after heart attacks
Disease control Not yet recruitingThis study compares a three-drug combination (atorvastatin, ezetimibe, and bempedoic acid) against the usual two-drug therapy for lowering LDL cholesterol in people who have had a recent heart attack or unstable angina. About 120 adults will take either the triple or dual therapy…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: PHASE4 • Sponsor: Punjab Institute of Cardology • Aim: Disease control
Last updated May 06, 2026 16:03 UTC
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New weekly shot aims to lower stubborn high cholesterol
Disease control Not yet recruitingThis study tests an experimental drug, alirocumab, given once a week to adults with high cholesterol. The goal is to see how well it lowers LDL (bad) cholesterol and what side effects may occur. About 420 participants will take different doses, and researchers will measure drug l…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: PHASE2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated May 01, 2026 15:57 UTC
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Health coaches empower patients to take control of chronic illnesses
Knowledge-focused Not yet recruitingThis study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: NA • Sponsor: Meharry Medical College • Aim: Knowledge-focused
Last updated May 17, 2026 02:56 UTC
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Japan study to reveal if patients stay on track with new cholesterol drugs
Knowledge-focused Not yet recruitingThis study looks at medical records from Japan to see how consistently patients take two different cholesterol-lowering medicines, inclisiran and evolocumab, over one year. It will include about 3,600 adults with high cholesterol. The goal is to understand real-world medication h…
Matched conditions: HYPERCHOLESTEROLEMIA
Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC
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Digital nudge: could a letter save your heart?
Knowledge-focused Not yet recruitingThis study will test if sending an electronic letter to 100,000 adults in Denmark with heart disease and high cholesterol encourages them to get their cholesterol checked. Some participants will also receive extra information about a related risk factor. The goal is to see if sim…
Matched conditions: HYPERCHOLESTEROLEMIA
Phase: NA • Sponsor: Tor Biering-Sørensen • Aim: Knowledge-focused
Last updated May 04, 2026 16:30 UTC