Weekly shot for high cholesterol? new trial tests more frequent dosing

NCT ID NCT07477704

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 6 times

Summary

This study tests whether a weekly dose of alirocumab (Praluent) is safe and effective for adults with high cholesterol. Alirocumab is already approved for use every two weeks, but this trial explores if giving it weekly works better. About 420 participants will receive different weekly doses, and researchers will track how much their LDL ('bad') cholesterol drops and watch for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: alirocumab (Praluent)
What this could lead to: If successful, this could show that weekly dosing of alirocumab is a safe and effective option for lowering high cholesterol.
What could go wrong: This is a mid-stage trial with 420 participants, so results are not final. The weekly dose may cause more side effects or not work better than the approved every-two-week regimen.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hypercholesterolemia hyperlipidemia Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERCHOLESTEROLEMIA

Contacts and locations

Locations

AMR Norman
RECRUITING

Norman, Oklahoma, 73069, United States
Accellacare of Wilmington
RECRUITING

Wilmington, North Carolina, 28401, United States
Altoona Center for Clinical Research
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Anaheim Clinical Trials
RECRUITING

Anaheim, California, 92801, United States
Balanced Life Health Care Solutions
RECRUITING

Lawrenceville, Georgia, 30046, United States
Be Well Clinical Studies - Round Rock
RECRUITING

Round Rock, Texas, 78681, United States
Cenexel CNS
RECRUITING

Los Alamitos, California, 90720, United States
Center for Advanced Research and Education
RECRUITING

Gainesville, Georgia, 30501, United States
Charlottesville Medical Research
RECRUITING

Charlottesville, Virginia, 22911, United States
Coastal Carolina Research Center_North Charleston
RECRUITING

North Charleston, South Carolina, 29405, United States
Consano Clinical Research, LLC
RECRUITING

Shavano Park, Texas, 78231, United States
Cullman Clinical Trials
RECRUITING

Cullman, Alabama, 35055, United States
Diablo Clinical Research - Flourish Research
RECRUITING

Walnut Creek, California, 94598, United States
East-West Medical Research Institute
RECRUITING

Honolulu, Hawaii, 96814, United States
Endeavor Clinical Trials
RECRUITING

San Antonio, Texas, 78240, United States
Flourish Research - San Antonio Medical Trials
RECRUITING

San Antonio, Texas, 78229, United States
K2 Medical Research The Villages
RECRUITING

The Villages, Florida, 32159, United States
L-MARC Research Center
RECRUITING

Louisville, Kentucky, 40213, United States
Lynn Health Science Institute
RECRUITING

Oklahoma City, Oklahoma, 73112, United States
Mercury Street Medical Group, PLLC
RECRUITING

Butte, Montana, 59701, United States
Ohio Clinical Trials
RECRUITING

Columbus, Ohio, 43212, United States
Palm Research Center, Mountainview Medical Center
RECRUITING

Las Vegas, Nevada, 89128, United States
Pinnacle Research Group
RECRUITING

Anniston, Alabama, 36207, United States
Precision Clinical Research
RECRUITING

Sunrise, Florida, 33351, United States
Rainier Clinical Research Center
RECRUITING

Renton, Washington, 98057, United States
Southwest General Healthcare Center
RECRUITING

Fort Myers, Florida, 33907, United States
Tampa Bay Medical Research
RECRUITING

Clearwater, Florida, 33761, United States
Tandem Clinical Research
RECRUITING

Marrero, Louisiana, 70072, United States
Tribe Clinical Research
RECRUITING

Greenville, South Carolina, 29607, United States
Valley Institute of Research, Rockwood Medical Clinic
RECRUITING

Fort Worth, Texas, 76164, United States
Velocity Clinical Research - Durham
RECRUITING

Durham, North Carolina, 27701, United States
Velocity Clinical Research - Omaha
RECRUITING

Omaha, Nebraska, 68134, United States
Velocity Clinical Research Dallas
RECRUITING

Dallas, Texas, 75230, United States
Velocity Clinical Research, Medford
RECRUITING

Medford, Oregon, 97504, United States

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