Heart attack drug aims to save tiny vessels

NCT ID NCT07380919

Recruiting now Disease control Sponsor: Federico II University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether the drug ranolazine can protect the tiny blood vessels in the heart after a heart attack. One hundred adults who had a major heart attack and have at least one other blocked artery will receive either ranolazine plus standard care or standard care alone. The main goal is to see if ranolazine helps keep the small vessels working better, measured by a special index at the start and after about six weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ranolazine
What this could lead to: If it works, this could point toward a new way to protect the heart's tiny blood vessels after a heart attack, potentially reducing long-term damage.
What could go wrong: This is a mid-stage trial with only 100 participants, so results may not apply to everyone. Ranolazine can cause side effects like dizziness, nausea, and constipation.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STEMI (ST ELEVATION MI)

Contacts and locations

Locations

Department of Cardiology, Santa Maria Goretti Hospital, Latina, Italy
NOT_YET_RECRUITING

Latina, Italy, Italy
Department of Medical and Surgical Sciences and "Renato Dulbecco" University Hospital, "Magna Graecia" University
RECRUITING

Catanzaro, Italy, 88100, Italy
Federico II University Hospital - Division of Cardiology
RECRUITING

Naples, Italy

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