Double vision for heart stents: could two scans beat one?
NCT ID NCT05333068
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two strategies for placing stents in people with multiple blocked heart arteries. One group gets standard guidance using a pressure wire (FFR), while the other also uses an imaging catheter (OCT) to spot unstable plaques. The goal is to see if the combined approach reduces deaths, heart attacks, and the need for more procedures over two years. About 1,200 adults aged 30-80 with at least two blockages are taking part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PCI revascularization strategy based on combined FFR and OCT assessment
What this could lead to
If successful, this approach could become a new standard for treating multiple blocked arteries, potentially lowering the risk of heart attacks and the need for repeat procedures.
What could go wrong
This is a large but still early-stage comparison; the combined strategy may not prove significantly better than standard care, and the added imaging could increase procedure time or cost without clear benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aarhus University Hospital
Aarhus, Denmark
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Albert Schweitzer Hospital
Dordrecht, Netherlands
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Apex Heart Institute
Ahmedabad, India
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Apollo Hospitals
Bangalore, India
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C.C. Iliescu Institute of Cardiology Bucharest
Bucharest, Romania
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Centre Hospitalier Régional Universitaire de Lille
Lille, France
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Charité - Universitätsmedizin Berlin
Berlin, Germany
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Cheng Hsin General Hospital
Taipei, Taiwan
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Clinic Hospital Targu Mures & S.C. Cardio Med SRL
Târgu Mureş, Romania
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Clinique Louis Pasteur
Nancy, France
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Danderyd Hospital
Stockholm, Sweden
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Elisabeth-TweeSteden Hospital
Tilburg, Netherlands
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Far Eastern Memorial Hospital
New Taipei City, Taiwan
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Hamilton Health Sciences
Hamilton, Canada
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Hospital Bellvitge Barcelona
Barcelona, Spain
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Hospital Clinico San Carlos
Madrid, Spain
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Hospital Clínic de Barcelona
Barcelona, Spain
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Hospital Gregorio Marañón Madrid
Madrid, Spain
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Hospital La Fe Valencia
Valencia, Spain
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Hospital Universitario Ramon y Cajal
Madrid, Spain
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Hospital de La Princesa
Madrid, Spain
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Humanitas Research Hospital
Milan, Italy
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Jagiellonian University; John Paul II Hospital
Krakow, Poland
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Linköping University
Linköping, Sweden
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Lund University
Lund, Sweden
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Marqués de Valdecilla University Hospital
Santander, Spain
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McGill University Health Centre
Montreal, Canada
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Medical University of Silesia
Katowice, Poland
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Medisch Spectrum Twente
Enschede, Netherlands
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Middle Slovak Institute of Cardiovascular Disease
Banská Bystrica, Slovakia
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Miedziowe Centrum Zdrowia
Lubin, Poland
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Monash Medical
Clayton, Australia
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National Heart Institute
Kuala Lumpur, Malaysia
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National Taiwan University Hospital
Taipei, Taiwan
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National University Corporation Institute of Science Tokyo
Bunkyō City, Japan
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Niagara Health System - St. Catherines Site
Saint Catharines, Canada
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Nicolae Stăncioiu Heart Institute
Cluj-Napoca, Romania
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North-Estonia Medical Centre
Tallinn, Estonia
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OLVG
Amsterdam, Netherlands
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Policlinico Universitario Fondazione Agostino Gemelli
Rome, Italy
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Post Graduate Institute of Medical education and Research
Chandigarh, India
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Regional Specialist Hospital
Wroclaw, Poland
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Universitetssjukhuset Örebro
Örebro, Sweden
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University Hospital Krakow
Krakow, Poland
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University Hospital La Paz
Madrid, Spain
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Universitätsklinikum Frankfurt
Frankfurt, Germany
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Warsaw Medical University
Warsaw, Poland
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Wellington Hospital
Wellington, New Zealand
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Yokohama City University Medical Center
Yokohama, Japan