Double vision for heart stents: could two scans beat one?

NCT ID NCT05333068

Ongoing Disease control Sponsor: Diagram B.V. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two strategies for placing stents in people with multiple blocked heart arteries. One group gets standard guidance using a pressure wire (FFR), while the other also uses an imaging catheter (OCT) to spot unstable plaques. The goal is to see if the combined approach reduces deaths, heart attacks, and the need for more procedures over two years. About 1,200 adults aged 30-80 with at least two blockages are taking part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PCI revascularization strategy based on combined FFR and OCT assessment
What this could lead to: If successful, this approach could become a new standard for treating multiple blocked arteries, potentially lowering the risk of heart attacks and the need for repeat procedures.
What could go wrong: This is a large but still early-stage comparison; the combined strategy may not prove significantly better than standard care, and the added imaging could increase procedure time or cost without clear benefit.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder ischemic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE ISCHEMIA MULTIVESSEL CORONARY ARTERY DISEASE VULNERABLE PLAQUE

Contacts and locations

Locations

Aarhus University Hospital

Aarhus, Denmark
Albert Schweitzer Hospital

Dordrecht, Netherlands
Apex Heart Institute

Ahmedabad, India
Apollo Hospitals

Bangalore, India
C.C. Iliescu Institute of Cardiology Bucharest

Bucharest, Romania
Centre Hospitalier Régional Universitaire de Lille

Lille, France
Charité - Universitätsmedizin Berlin

Berlin, Germany
Cheng Hsin General Hospital

Taipei, Taiwan
Clinic Hospital Targu Mures & S.C. Cardio Med SRL

Târgu Mureş, Romania
Clinique Louis Pasteur

Nancy, France
Danderyd Hospital

Stockholm, Sweden
Elisabeth-TweeSteden Hospital

Tilburg, Netherlands
Far Eastern Memorial Hospital

New Taipei City, Taiwan
Hamilton Health Sciences

Hamilton, Canada
Hospital Bellvitge Barcelona

Barcelona, Spain
Hospital Clinico San Carlos

Madrid, Spain
Hospital Clínic de Barcelona

Barcelona, Spain
Hospital Gregorio Marañón Madrid

Madrid, Spain
Hospital La Fe Valencia

Valencia, Spain
Hospital Universitario Ramon y Cajal

Madrid, Spain
Hospital de La Princesa

Madrid, Spain
Humanitas Research Hospital

Milan, Italy
Jagiellonian University; John Paul II Hospital

Krakow, Poland
Linköping University

Linköping, Sweden
Lund University

Lund, Sweden
Marqués de Valdecilla University Hospital

Santander, Spain
McGill University Health Centre

Montreal, Canada
Medical University of Silesia

Katowice, Poland
Medisch Spectrum Twente

Enschede, Netherlands
Middle Slovak Institute of Cardiovascular Disease

Banská Bystrica, Slovakia
Miedziowe Centrum Zdrowia

Lubin, Poland
Monash Medical

Clayton, Australia
National Heart Institute

Kuala Lumpur, Malaysia
National Taiwan University Hospital

Taipei, Taiwan
National University Corporation Institute of Science Tokyo

Bunkyō City, Japan
Niagara Health System - St. Catherines Site

Saint Catharines, Canada
Nicolae Stăncioiu Heart Institute

Cluj-Napoca, Romania
North-Estonia Medical Centre

Tallinn, Estonia
OLVG

Amsterdam, Netherlands
Policlinico Universitario Fondazione Agostino Gemelli

Rome, Italy
Post Graduate Institute of Medical education and Research

Chandigarh, India
Regional Specialist Hospital

Wroclaw, Poland
Universitetssjukhuset Örebro

Örebro, Sweden
University Hospital Krakow

Krakow, Poland
University Hospital La Paz

Madrid, Spain
Universitätsklinikum Frankfurt

Frankfurt, Germany
Warsaw Medical University

Warsaw, Poland
Wellington Hospital

Wellington, New Zealand
Yokohama City University Medical Center

Yokohama, Japan

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