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Gum fluid proteins may hold clues to periodontal disease severity

NCT ID NCT07793370

Knowledge-focused Sponsor: Abant Izzet Baysal University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This observational study measures three proteins, PTHrP, RANKL, and OPG, in the fluid that seeps from the gums. Researchers will compare levels in 81 adults split into three groups: healthy gums, gingivitis, and periodontitis. During a routine dental exam, they collect fluid samples with small paper strips and analyze the proteins in the lab. The goal is to see whether these proteins track with gum health and disease severity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Routine periodontal examination and gingival crevicular fluid collection
What this could lead to
If the markers differ between healthy gums, gingivitis, and periodontitis, they could become tools for diagnosing or monitoring gum disease.
What could go wrong
This is a small observational study, so it can only show associations, not cause and effect. The markers may not prove useful in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

81 people

The number who actually took part.

Started

Jun 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult individuals seeking dental care at the Department of Periodontology, Faculty of Dentistry, Bolu Abant Izzet Baysal University. The population includes a total of 81 participants representing three distinct periodontal conditions: individuals with a healthy periodontium, individuals diagnosed with gingivitis, and individuals diagnosed with Stage III periodontitis.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 18 years and older. * Presence of at least 20 natural teeth, excluding third molars. * For the Periodontally Healthy GrouP: PD ≤ 3 mm, BOP \< 10%, and no interproximal CAL or RBL. * For the Gingivitis Group: PD ≤ 3 mm, BOP ≥ 30%, and no interproximal CAL or RBL. * For the Periodontitis Group: Diagnosed with Stage III periodontitis (interproximal CAL ≥ 5 mm, PD ≥ 6 mm, and RBL extending to the middle third of the root or more apically). Exclusion Criteria: * Presence of systemic diseases that may affect periodontal tissues (e.g., cardiovascular diseases, atherosclerosis, immune system diseases, rheumatoid arthritis, obesity, cancer, and diabetes). * Use of antibiotics within the last 3 months. * Use of any medication that may affect periodontal tissues. * Presence of infectious diseases such as HIV, HBV, or tuberculosis. * Pregnancy or lactation. * History of periodontal treatment within the last 6 months. * Smoking

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Conditions

The condition(s) this trial relates to.

gingivitis periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis Periodontal disease Periodontitis

Contacts and locations

Locations

  • Bolu Abant İzzet Baysal University, Faculty of Dentistry, Department of Periodontology

    Bolu, Gölköy, 14030, Turkey (Türkiye)

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