PERIODONTAL DISEASE

This study tests whether taking omega-3 fatty acids (fish oil) plus low-dose aspirin can improve gum disease treatment in smokers with advanced periodontitis. Participants receive these supplements or a placebo alongside standard deep-cleaning procedures. The trial measures chang…

This study tests a new, gentler way to clean deep gum pockets in people with advanced periodontitis. It compares a standard deep-cleaning method using larger tools to a minimally invasive approach using thinner, more delicate instruments. The goal is to see if the gentler method …

This study compares a test interdental brush to other interdental brushes in 88 adults with active periodontal disease. Over 4 weeks, researchers will measure plaque, gum bleeding, and pocket depth to see which brush works best. Participants use the brush twice daily and report a…

This study looks at whether adding a diode laser to standard deep cleaning (scaling and root planing) improves gum disease treatment. Twenty adults with moderate to severe gum disease will have each side of their mouth randomly assigned to cleaning alone or cleaning plus laser. T…

This study tests whether a gel containing lovastatin, a cholesterol drug, can improve standard gum disease treatment. Researchers will compare the medicated gel to a placebo gel in 44 adults with periodontitis, including both smokers and non-smokers. The goal is to see if the gel…

This study tests whether adding a daily probiotic tablet and a coenzyme Q10 toothpaste to standard gum cleaning can improve oral health in pregnant women. Forty pregnant women will be split into two groups: one gets the probiotic plus Q10 toothpaste, the other gets only the Q10 t…

This study tests if a probiotic spray containing good bacteria can help prevent and treat gum disease in older adults. Researchers will give 90 elderly participants either the probiotic spray or a placebo for four weeks. They will measure changes in gum health, bleeding, and bad …

This study tests whether a hydrogen peroxide mouth rinse (OROXID®) can improve gum health when used alongside standard dental cleaning. About 90 adults with moderate-to-severe gum disease will use either a 1.5% or 3% rinse or a control rinse for 12 weeks. The goal is to see if it…

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study tests whether using a lactoferrin-based toothpaste and mouthwash twice daily, along with regular professional cleanings, can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpas…

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study surveys 100 general practitioners in Italy to assess their knowledge of how oral health, especially gum disease, relates to systemic conditions like diabetes. Participants complete a 35-question digital questionnaire. The goal is to identify gaps in knowledge and impro…

This study is checking how often the fungus Candida albicans shows up in the gums of 100 Syrian adults with periodontitis (serious gum disease). Researchers will collect plaque samples and measure gum health to see if the fungus is linked to more severe disease. The goal is to be…

This study looks at whether sleep quality is linked to gum disease (periodontitis). Researchers will measure sleep quality, fatigue, and certain substances in saliva from 48 healthy adults with or without gum disease. The goal is to better understand how oral health and sleep are…

This study looks at how gum disease and smoking change certain proteins in saliva. Researchers will collect saliva and check gum health in 116 people with and without periodontitis. The goal is to see if these proteins can help diagnose gum disease and understand smoking's role.

This study looks at a protein called Mitofusin-1 in saliva to see if it can help measure how severe gum disease is and how well treatment works. Researchers will compare healthy people, those with mild to severe gum disease, and smokers with severe gum disease. Participants give …

This observational study in 46 people with severe gum disease aims to understand how two types of gum tissue (infra-osseous and supra-osseous granulation tissue) differ in their healing potential and infection-fighting properties. Researchers will collect tissue samples during pe…