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Gum disease showdown: platelet gel, laser, or iodine – which works best?

NCT ID NCT07707063

Recruiting now Disease control Sponsor: Military Hospital of Tunis Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests three add-on treatments for gum disease: a platelet-rich fibrin gel (I-PRF), a diode laser, and an iodine rinse. Each is used alongside standard deep cleaning in smokers and non-smokers with moderate to severe periodontitis. The goal is to see which approach best reduces bleeding, pocket depth, and gum attachment loss over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (I-PRF), diode laser, and 1% povidone-iodine irrigation
What this could lead to
If successful, these add-on treatments could become standard options to improve gum health after deep cleaning, especially for smokers.
What could go wrong
This is a small, early-phase trial with only 50 participants. Results may not apply to all patients, and the benefits over standard care could be small.

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Conditions

The condition(s) this trial relates to.

periodontal disorder Periodontal Pocket periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON SMOKERS PERIODONTAL DISEASE PERIODONTITIS SMOKERS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Military Hospital of Instruction of Tunis

    RECRUITING

    Tunis, Mont Fleury, 1008, Tunisia

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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