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Gum disease showdown: platelet gel, laser, or iodine – which works best?

NCT ID NCT07707063

Disease control Sponsor: Military Hospital of Tunis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests three add-on treatments for gum disease: a platelet-rich fibrin gel (I-PRF), a diode laser, and an iodine rinse. Each is used alongside standard deep cleaning in smokers and non-smokers with moderate to severe periodontitis. The goal is to see which approach best reduces bleeding, pocket depth, and gum attachment loss over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (I-PRF), diode laser, and 1% povidone-iodine irrigation
What this could lead to
If successful, these add-on treatments could become standard options to improve gum health after deep cleaning, especially for smokers.
What could go wrong
This is a small, early-phase trial with only 50 participants. Results may not apply to all patients, and the benefits over standard care could be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion: Patients with Stage II-IV Periodontitis; at least one bleeding pocket \> 4 mm minimum in every quadrant. Exclusion: patients who: * Pregnant /Lactating * History of radiotherapy or chemotherapy in the head/neck region. * Known hypersensitivity to Iodine or Methylene blue solution * Systematic antibiotic use within the last 30 days * Long-term use of immunosuppressants or corticosteroids (daily use) * type 1 / 2 diabetes

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Conditions

The condition(s) this trial relates to.

periodontal disorder Periodontal Pocket periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non smokers Periodontal disease Periodontitis Smokers

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Military Hospital of Instruction of Tunis

    RECRUITING

    Tunis, Mont Fleury, 1008, Tunisia

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