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Could a toothbrush and mouthwash cut pneumonia in the elderly?

NCT ID NCT07807397

Prevention Sponsor: Colgate Palmolive Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many residents develop pneumonia during the trial, along with their oral health and diabetes status.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Stannous fluoride toothpaste, sodium fluoride toothpaste, cetylpyridinium chloride and zinc mouthwash, sodium fluoride mouthwash, chlorhexidine mouthwash, and a connected toothbrush
What this could lead to
If effective, this program could reduce pneumonia cases among elderly nursing home residents by improving daily oral hygiene.
What could go wrong
The trial is early and results may not show a clear benefit. Some mouthwashes may cause side effects like staining or taste changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed Informed Consent Form to receive on-site dental care and grant access to their medical and dental records, and Consent for information collection, consultation, and disease control oral healthcare treatment * Male and female subjects aged 60 years or older. * A resident of one of the nursing home sites. * ASA physical classification status of II, III, or IV (excluding high frailty scores) * Frailty assessment of low or moderate Exclusion Criteria: * Tumor(s) of the soft or hard tissues of the oral cavity. * History of allergies to oral care/personal care consumer products or their ingredients. * ASA category V patients * High frailty assessment * Resident deemed behaviorally difficult in interview or initial assessment * Endentulous * Fractured teeth and/or root tips present * Oral lesions * Grossly mobile teeth for Cohort B * Temporary crowns for Cohort B

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Conditions

The condition(s) this trial relates to.

dental caries gingivitis periodontal disorder pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries,dental Elderly Gingivitis Periodontal disease

How to take part

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  1. The official record

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