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A gel that may save the tooth next door: wisdom tooth extraction gets a preventive upgrade

NCT ID NCT07718932

Recruiting now Disease control Sponsor: Aristotle University Of Thessaloniki Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether applying a regenerative gel called Emdogain to the root of the second molar during wisdom tooth removal can prevent the deep pockets and bone loss that often develop on that tooth afterward. The study involves 70 healthy adults who need a lower wisdom tooth removed. Half will receive the gel during surgery; the other half will heal naturally. Researchers will measure changes in gum attachment and bone levels over six months to see if the gel leads to better healing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a regenerative gel made from enamel matrix proteins (Emdogain)
What this could lead to
If it works, this could offer a simple, one-time preventive step during wisdom tooth extraction to protect the adjacent molar from gum disease and bone loss.
What could go wrong
This is a small, early-stage trial with 70 participants. The gel may not improve healing over natural recovery, and its effects beyond 6 months are unknown.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder Periodontal Pocket

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALVEOLAR BONE LOSS IMPACTED TOOTH WITH ABNORMAL POSITIONING PERIODONTAL POCKET

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • 424 General Military Hospital

    RECRUITING

    Thessaloniki, Greece

  • Aristotle University of Thessaloniki

    RECRUITING

    Thessaloniki, Greece

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