New gum surgery aims to save teeth from advanced periodontitis

NCT ID NCT03997578

Recruiting now Disease control Sponsor: Universidad de Murcia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new surgical technique called NIPSA, combined with a gum graft and special proteins, to treat severe gum disease. Forty adults with periodontitis and deep gum pockets will receive the procedure. The goal is to see if this approach can reduce pocket depth and improve gum attachment better than standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: connective tissue graft plus enamel matrix derivative and xenograft
What this could lead to: If successful, this could offer a more effective surgical option to repair gum and bone damage from periodontitis, potentially saving teeth that might otherwise be lost.
What could go wrong: This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. Surgery carries risks like infection, pain, or graft failure, and long-term benefits are not yet proven.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIODONTAL BONE LOSS PERIODONTAL; LESION PERIODONTITIS

Contacts and locations

Locations

Centro Odontologico Del Sureste Slp
RECRUITING

Murcia, 30007, Spain

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