Gel and bone graft combo aims to regrow Gum-Damaged bone

NCT ID NCT07522684

Recruiting now Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a gel made from polynucleotide and hyaluronic acid, combined with a bone graft, can help repair bone defects caused by advanced gum disease. 66 adults with severe periodontitis will receive either standard surgery, surgery with bone graft alone, or surgery with both the gel and bone graft. Researchers will measure bone and gum healing over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: polynucleotide and hyaluronic acid gel combined with xenogeneic bone graft
What this could lead to: If successful, this could offer a better way to regenerate bone and tissue around teeth damaged by gum disease, improving tooth stability and reducing the need for extractions.
What could go wrong: This is a small, early-stage trial with only 66 people, so results may not apply to everyone. The gel is new for this use, and its benefits over standard treatments are not yet proven.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIODONTITIS

Contacts and locations

Locations

Ribeirão Preto School of Dentistry, University of São Paulo
RECRUITING

Ribeirão Preto, São Paulo, 14040904, Brazil

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