Cholesterol drug could help heal infected teeth
NCT ID NCT07256561
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether simvastatin, a common cholesterol drug, can fight infection and reduce inflammation when placed inside a tooth during root canal retreatment. Fifty-four adults with a single-rooted tooth that had a failed root canal and a small area of bone loss around the tip will receive either simvastatin or a standard calcium hydroxide paste. The goal is to see if simvastatin improves healing of the bone and reduces infection better than the usual treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- simvastatin
- What this could lead to
- If it works, this could offer a better way to control infection and reduce inflammation during root canal retreatment, potentially improving healing.
- What could go wrong
- This is a small, early-stage trial with only 54 participants. Simvastatin is not approved for this use, and its effects inside a tooth may differ from its usual use. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Dental Medicine for Girls, Al-Azhar University
RECRUITINGCairo, Egypt
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Other studies related to the condition(s) this trial covers.