Cholesterol drug could help heal infected teeth
NCT ID NCT07256561
First seen Jan 04, 2026 · Last updated Jun 20, 2026 · Updated 24 times
Summary
This study tests whether simvastatin, a common cholesterol drug, can fight infection and reduce inflammation when placed inside a tooth during root canal retreatment. Fifty-four adults with a single-rooted tooth that had a failed root canal and a small area of bone loss around the tip will receive either simvastatin or a standard calcium hydroxide paste. The goal is to see if simvastatin improves healing of the bone and reduces infection better than the usual treatment.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Faculty of Dental Medicine for Girls, Al-Azhar University
RECRUITINGCairo, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
simvastatin
What this could lead to
If it works, this could offer a better way to control infection and reduce inflammation during root canal retreatment, potentially improving healing.
What could go wrong
This is a small, early-stage trial with only 54 participants. Simvastatin is not approved for this use, and its effects inside a tooth may differ from its usual use. Results may not apply to all patients.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.