Gum disease treatment: can a hyaluronic acid gel regrow bone as well as the standard?

NCT ID NCT07339605

Recruiting now Disease control Sponsor: University of Valencia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a hyaluronic acid gel can help regrow bone lost to severe gum disease, compared to the standard enamel matrix derivative gel or no gel at all. All treatments use a minimally invasive, non-surgical technique. Sixty adults with advanced periodontitis will be followed for one year to measure bone fill and patient satisfaction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyaluronic acid gel and enamel matrix derivative
What this could lead to: If successful, this could offer a simpler, less invasive option for regenerating bone lost to gum disease, potentially reducing the need for surgery.
What could go wrong: This is a small, early-stage trial with only 60 participants. The results may not apply to everyone, and the benefits over standard care are still uncertain.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss disease human disease periodontitis periodontitis, aggressive 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALVEOLAR BONE LOSS* / THERAPY DENTAL ENAMEL PROTEINS* / THERAPEUTIC USE FLAPLESS GUIDED TISSUE REGENERATION, PERIODONTAL / METHODS HUMANS HYALURONIC ACID* / THERAPEUTIC USE INTRABONY DEFECT

Contacts and locations

Locations

Clínica Odontológica de la Universidad de Valencia
RECRUITING

Valencia, Valencia, 46010, Spain

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