New hope for painful hand and foot pustules: phase 3 trial launches

NCT ID NCT07219420

Recruiting now Disease control Sponsor: UCB Biopharma SRL Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an option to continue on the drug afterward. The main goal is to see how many achieve clear or almost clear skin at week 16.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

bimekizumab (BIMZELX)

What this could lead to

If it works, this could provide a new treatment option for people with painful pustules on hands and feet.

What could go wrong

This is a late-stage trial, but results may not apply to all patients. Side effects are possible, and the drug may not work better than placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

palmoplantar pustulosis periodontitis, aggressive 1 psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PALMOPLANTAR PUSTULOSIS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ppp001 20022
RECRUITING

Hangzhou, China
Ppp001 20104
RECRUITING

Seoul, South Korea
Ppp001 20136
RECRUITING

Tianjin, China
Ppp001 20137
RECRUITING

Chengdu, China
Ppp001 20184
RECRUITING

Shenzhen, China
Ppp001 20193
RECRUITING

Hangzhou, China
Ppp001 20208
RECRUITING

Seongnam-si, South Korea
Ppp001 20211
RECRUITING

Bucheon-si, South Korea
Ppp001 20214
RECRUITING

Busan, South Korea
Ppp001 20215
RECRUITING

Gwangju, South Korea
Ppp001 20311
RECRUITING

Guangzhou, China
Ppp001 20313
RECRUITING

Guangzhou, China
Ppp001 20344
RECRUITING

Jinan, China
Ppp001 20345
RECRUITING

Shanghai, China
Ppp001 20350
RECRUITING

Chongqing, China
Ppp001 20351
RECRUITING

Seoul, South Korea
Ppp001 20352
RECRUITING

Chengdu, China
Ppp001 20353
RECRUITING

Yinchuan, China
Ppp001 20354
RECRUITING

Seoul, South Korea
Ppp001 20355
RECRUITING

Jinan, China
Ppp001 20356
RECRUITING

Xi'an, China
Ppp001 20357
RECRUITING

Beijing, China
Ppp001 20366
RECRUITING

Anyang-si, South Korea
Ppp001 20367
RECRUITING

Jeonju, South Korea
Ppp001 40108
RECRUITING

Salford, United Kingdom
Ppp001 40113
RECRUITING

London, United Kingdom
Ppp001 40203
RECRUITING

Budapest, Hungary
Ppp001 40230
RECRUITING

Valencia, Spain
Ppp001 40249
RECRUITING

Kiel, Germany
Ppp001 40266
RECRUITING

Badalona, Spain
Ppp001 40297
RECRUITING

Manises, Spain
Ppp001 40334
RECRUITING

Wroclaw, Poland
Ppp001 40356
RECRUITING

Dresden, Germany
Ppp001 40366
RECRUITING

Rostock, Germany
Ppp001 40396
RECRUITING

Rzeszów, Poland
Ppp001 40515
RECRUITING

Berlin, Germany
Ppp001 40567
RECRUITING

Roma, Italy
Ppp001 40604
RECRUITING

Warsaw, Poland
Ppp001 40625
RECRUITING

Warsaw, Poland
Ppp001 40626
RECRUITING

Bialystok, Poland
Ppp001 40637
RECRUITING

Gdansk, Poland
Ppp001 40740
RECRUITING

Bad Bentheim, Germany
Ppp001 40743
RECRUITING

Szczecin, Poland
Ppp001 40747
RECRUITING

Mainz, Germany
Ppp001 40750
RECRUITING

Alicante, Spain
Ppp001 40757
RECRUITING

Poznan, Poland
Ppp001 40788
RECRUITING

Torun, Poland
Ppp001 40816
RECRUITING

Brescia, Italy
Ppp001 40830
RECRUITING

Rozzano, Italy
Ppp001 40862
RECRUITING

Wroclaw, Poland
Ppp001 40866
RECRUITING

Göttingen, Germany
Ppp001 40868
RECRUITING

Valencia, Spain
Ppp001 40874
RECRUITING

Nice, France
Ppp001 40875
RECRUITING

Ahaus, Germany
Ppp001 40878
RECRUITING

Katowice, Poland
Ppp001 40880
RECRUITING

London, United Kingdom
Ppp001 40881
RECRUITING

Ústí nad Labem, Czechia
Ppp001 40885
RECRUITING

Granada, Spain
Ppp001 40886
RECRUITING

Hellerup, Denmark
Ppp001 40887
RECRUITING

Toulon, France
Ppp001 40888
RECRUITING

Madrid, Spain
Ppp001 40889
RECRUITING

Málaga, Spain
Ppp001 40891
RECRUITING

Bielefeld, Germany
Ppp001 40892
RECRUITING

Lübeck, Germany
Ppp001 40893
RECRUITING

Bochum, Germany
Ppp001 40894
RECRUITING

Orosháza, Hungary
Ppp001 40895
RECRUITING

Debrecen, Hungary
Ppp001 40915
RECRUITING

Krakow, Poland
Ppp001 50233
RECRUITING

Barrie, Canada
Ppp001 50354
RECRUITING

Calgary, Canada
Ppp001 50740
RECRUITING

Québec, Canada
Ppp001 50745
RECRUITING

Columbus, Ohio, 43213, United States
Ppp001 50746
RECRUITING

Coral Gables, Florida, 33134, United States
Ppp001 50749
RECRUITING

Fredericton, Canada
Ppp001 50750
RECRUITING

Surrey, Canada
Ppp001 50752
RECRUITING

Red Deer, Canada
Ppp001 50765
RECRUITING

London, Canada