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Can a pomegranate peel gel boost gum healing?

NCT ID NCT07725393

Disease control Sponsor: gehad samy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether a gel made from pomegranate peel extract, placed directly into deep gum pockets after a standard deep cleaning, can improve healing in people with moderate to advanced gum disease (periodontitis). Thirty-two adults will receive the gel on one side of the mouth and a placebo gel on the other, with gum measurements and inflammatory markers tracked over six months. The goal is to see if this natural extract can reduce pocket depth and attachment loss better than cleaning alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a gel made from pomegranate peel extract, applied directly to the gums after deep cleaning
What this could lead to
If it works, this could offer a simple, natural addition to standard gum disease treatment to improve healing and reduce pocket depth.
What could go wrong
This is a very small, early-stage trial. The gel may not provide any benefit over standard cleaning alone, and natural extracts can vary in potency.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 30 to 60 years. * Systemically healthy individuals. * Diagnosis of Stage II or Stage III periodontitis according to the 2018 Classification of Periodontal and Peri-Implant Diseases and Conditions. * Presence of at least 20 natural teeth. * Presence of at least two non-adjacent periodontal pockets (≥5 mm) located in different quadrants suitable for split-mouth allocation. * Clinical attachment loss consistent with Stage II or Stage III periodontitis. * Ability and willingness to comply with the study protocol and attend all follow-up visits. * Provision of written informed consent. Exclusion Criteria: * Current smokers or users of any tobacco products. * Pregnant or lactating women. * Patients with systemic diseases known to affect periodontal status or wound healing (e.g., uncontrolled diabetes mellitus, immunodeficiency disorders, osteoporosis requiring antiresorptive therapy). * Use of systemic antibiotics, corticosteroids, immunosuppressive agents, or non-steroidal anti-inflammatory drugs within the previous 3 months. * Periodontal therapy received within the previous 6 months. * History of allergy or hypersensitivity to pomegranate or any component of the study materials. * Orthodontic treatment during the study period. * Participation in another clinical trial within the previous 6 months.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Faculty of Dental Medicine for Girls, Al-Azhar University

    RECRUITING

    Cairo, Cairo Governorate, Egypt

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