Periodontal disorder

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This trial tests whether adding a sticky bone graft to a standard gum flap procedure helps cover exposed tooth roots better than the flap alone. It includes 30 adults with mild-to-moderate gum recession. The study measures how much the gum covers the root and how thick the gum ti…

This study compares two minimally invasive treatments for deep gum disease bone defects: a non-surgical approach (MINST) and a surgical one (MIST). Researchers want to see if the non-surgical method can achieve similar bone and gum attachment improvements as surgery, but with les…

This study tested a procedure that uses a patient's own growth factors to help rebuild lost jawbone. Eleven people with severe bone loss in the upper jaw received a bone graft mixed with plasma rich in growth factors. After 6-9 months, enough bone had grown to place dental implan…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study tested two different materials used in root canal treatment for teeth with both root and gum infections. 120 adults received either a mineral-based plug (MTA) or a standard resin sealer. Researchers measured healing and inflammation markers after one year to see which …

This study tested whether adding a light-based antibacterial treatment called photodynamic therapy (PDT) to standard deep cleaning improves gum health in people with moderate gum disease. Thirty adults received standard cleaning on one side of the mouth and standard cleaning plus…

This study tests whether a gel made from spirulina (a type of algae) can improve the treatment of stage II gum disease when used alongside standard deep cleaning. Researchers will compare different ways of preparing the spirulina gel and measure gum health and inflammation levels…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether adding a light-activated therapy, called antimicrobial photodynamic therapy (aPDT), to standard deep-cleaning for gum disease could kill more bacteria and improve gum health. Fifty adults with severe periodontitis received standard cleaning alone or with…

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to s…

This study tested whether a hands-on teaching method called Touch-to-Teach helps people with dental crowns clean between their teeth better than standard advice. 36 adults with at least one crown took part and were split into two groups: one got personalized brush training, the o…

This early-phase study tested whether an ozonated sunflower seed oil gel could improve gum disease treatment when used alongside standard deep cleaning. Sixty adults with stage II periodontitis were divided into groups receiving either cleaning alone or cleaning plus a regular or…

This completed study tested a surgical technique called the combined bilaminar tunnel method for treating gum recession in patients with challenging tooth anatomy. Twelve participants received the procedure and were followed for six months. The goal was to see how much of the exp…

This study tested two types of bone graft materials—alloplastic (man-made) and xenograft (from animals)—to rebuild jaw bone in 20 people who needed dental implants. Each person received both materials in different sides of their jaw so the results could be directly compared. The …

This study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing…

This study looked at whether adding ozone gas to standard deep cleaning helps treat severe gum disease (periodontitis). 39 adults received the usual cleaning plus ozone, and researchers measured bacteria levels and gum pocket depths. The goal was to see if ozone kills more bacter…

This study tested a new, less invasive way to treat infected baby molars in children aged 4 to 10. Instead of fully cleaning out the tooth canals (standard pulpectomy), the new method uses an antibiotic paste to kill infection without drilling. The study involved 110 children and…

This study tested whether adding platelet-rich fibrin (a concentrate from your own blood) plus the antibiotic minocycline works better than the antibiotic Arestin alone for treating gum disease. Fifteen adults with moderate gum disease received both treatments in different parts …

This study tested a new surgical technique called the NORD flap for treating receding gums, comparing it to the standard method that uses a tissue graft from the roof of the mouth. The goal was to see if the new technique could cover exposed tooth roots just as well, with less pa…

This study tested whether a melatonin gel applied to the gums can improve the results of standard deep-cleaning treatment for gum disease. Thirty adults with periodontitis received either the melatonin gel or a placebo gel alongside their regular dental cleaning. Researchers meas…

This study looked at 51 adults with advanced gum disease and loose front teeth. Researchers compared minimally invasive non-surgical therapy (MINST) alone versus MINST plus splinting (joining teeth together for support). The goal was to see if adding splints improves gum health a…

This study tested whether adding photodynamic therapy (a light-based treatment) and vitamin D to standard deep cleaning helps people with moderate gum disease. Twenty-four adults with stage II grade B periodontitis took part. The goal was to see if the combination improves gum at…

This study looked at how well a special dental material (calcium silicate sealer) works when re-treating root canals that have failed. 136 adults aged 18-65 with infected teeth were included. The main goal was to see if the infection healed on 3D X-rays and if symptoms like pain …

This study tested whether a special oral gel called PHTALOX® could make standard deep-cleaning treatments for gum disease more effective. Forty-five adults with moderate to severe periodontitis received standard scaling and root planing, plus either the PHTALOX® gel, a chlorhexid…

This study tested whether using a stannous fluoride toothpaste, a cetylpyridinium chloride mouthwash, and a battery-powered toothbrush together can reduce dental plaque and gingivitis (gum inflammation). 134 adults with at least 20 teeth and signs of gum disease used the regimen …

This study tested whether adding ozone gas to a standard deep cleaning (scaling and root planing) helps treat stubborn gum pockets in people with advanced gum disease. Twenty-six adults with stage III or IV periodontitis and pockets 5mm or deeper took part. Researchers measured g…

This study tested whether taking omega-3 or vitamin D supplements daily helps treat gum disease (periodontitis) better than standard deep cleaning alone. 72 adults with moderate gum disease received either omega-3, vitamin D, or no supplement alongside their dental treatment. Res…

This study compared a liquorice nanogel to a diode laser as extra treatments for advanced gum disease (stage III). 27 adults with deep gum pockets received one of the two treatments alongside standard care. The goal was to see which approach better reduced harmful bacteria and im…

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each pers…

This study tested a collagen-based gel called H42 in 38 adults with gum disease (periodontitis). The gel was placed into deep gum pockets after standard cleaning. Researchers measured how much pocket depth decreased over 12 weeks, along with other signs of gum health and patient …

This study looked at whether adding probiotics or antibiotics to standard non-surgical gum disease treatment helps improve gum health. Sixty adults with severe periodontitis took part. The goal was to see if probiotics could be a safer alternative to antibiotics, which can cause …

This study tested a surgical technique for treating multiple receding gums. Twenty-one adults with gum recession on both sides of the mouth received a modified tunnel procedure with a connective tissue graft. The researchers compared two ways of placing the graft to see which gav…

This study tested two ways to treat receding gums: a new material made from the patient's own blood (T-PRF) and a standard connective tissue graft. Twenty healthy adults with gum recession on both sides of the mouth received both treatments, one on each side. The researchers meas…

This study tested two ways to widen a narrow lower jawbone so dental implants can be placed. One method used AI and computer guidance to make tiny holes in the bone, while the other did the same procedure by hand. The goal was to see which approach is safer and more effective. Tw…

This study tested a chlorhexidine varnish applied to teeth in people with braces. Each person's mouth was split: one side got the active varnish, the other a placebo. Over 3 months, researchers measured gum overgrowth, plaque buildup, and early tooth decay (white spots). The goal…

This study tested whether adding microneedling before standard gum surgery (coronally advanced flap) improves root coverage for people with thin gums and receding gums. Thirty-six adults with isolated gum recession on upper front teeth were randomly assigned to receive either mic…

This study tested whether a custom digital surgical guide helps dentists perform crown lengthening more accurately than the usual method. Twenty-four adults with gummy smiles due to a condition called altered passive eruption took part. The digital guide uses 3D scans and imaging…

This study looked at whether adding a deproteinized bovine (cow) bone graft around immediate dental implants helps them heal better in the front upper jaw. Sixteen adults with hopeless teeth were split into two groups: one got implants with the bone graft, the other without. Rese…

This study tested whether a mouthrinse with benzydamine hydrochloride could reduce plaque buildup when people stopped brushing for three days. Fifty healthy women with no gum disease used either the active mouthrinse or a placebo. The results showed no significant difference in p…

This study tested whether toothpaste containing hops extract can reduce gum inflammation (gingivitis) better than standard fluoride toothpaste. 120 adults brushed twice daily for 3 months with one of four toothpastes. Researchers measured bleeding and gum health to see if the hop…

This study tested a special food-grade formula applied to the gums in 20 adults with chronic gum disease. Researchers observed that gum redness and bleeding improved within 7 to 14 days. The approach aims to repair gum tissue without surgery, but larger and more rigorous studies …

This study tested whether a new mouthwash called MicroRepair ABX works as well as the standard chlorhexidine mouthwash for treating plaque-induced gingivitis (gum inflammation). Forty adults with gum disease used one of the two mouthwashes twice daily for 14 days after a professi…

This study tested whether adding ozone therapy to standard gum surgery improves outcomes for people with advanced gum disease (stage III periodontitis). Twenty-four adults received surgery on both sides of their mouth, with one side also getting ozone treatment. Researchers measu…

This study tested whether using a calibrated interdental brush (sized to fit each gap) reduces gum bleeding better than a non-calibrated brush in 51 healthy young adults aged 18-30. Participants used one type of brush daily for three months. The main goal was to compare gum infla…

This study tested whether adding vitamins A and C to a platelet-rich fibrin (PRF) treatment helps repair bone defects in the gums. Twenty-eight adults with advanced gum disease received a minimally invasive surgical technique with PRF, with or without the vitamins. The goal was t…

This study tested four different mouthwashes—hydrogen peroxide with hyaluronic acid, hyaluronic acid alone, chlorhexidine, and a placebo—in 80 healthy adults aged 18 to 35 with mild gum inflammation. Participants used their assigned rinse twice daily for three weeks. The goal was…

This study tested whether adding chlorhexidine and zinc to standard deep-cleaning (scaling and root planing) improves gum health in people with early-stage periodontitis. 44 participants were split into two groups: one received the standard cleaning with the antimicrobial solutio…

This study looked at whether eating an amla berry (Indian gooseberry) along with standard deep cleaning helps people with chronic gum disease more than cleaning alone. Thirty adults with moderate to severe gum disease were split into two groups: one got cleaning plus amla, the ot…

This study tested whether injectable platelet-rich fibrin (i-PRF), titanium platelet-rich fibrin (t-PRF), or hyaluronic acid gel can improve wound healing after gum surgery for overgrown gums. Sixty healthy adults were randomly assigned to one of four groups. Researchers measured…

This study looked at whether a special gel could help treat gum disease. Twelve adults with moderate gum disease received standard deep cleaning plus the gel. They also used the gel and a special toothpaste at home. After 8 weeks, their gum pockets and bleeding improved. The stud…

This study tested a porcine collagen matrix (Mucoderm) against the standard connective tissue graft for covering exposed tooth roots due to gum recession. Eighteen adults with gum recession on both sides of the mouth received one treatment on each side. The goal was to see if the…

This study tested whether taking antibiotics along with standard deep-cleaning treatment (scaling and root planing) improves gum health in adults with periodontitis. 236 participants from dental practices across the U.S. were randomly assigned to receive either antibiotics (amoxi…

This study looked at whether adding platelet-rich fibrin (PRF) or injectable PRF, made from a patient's own blood, to standard deep cleaning can improve gum health in people with periodontitis. 56 participants received either standard treatment alone or with PRF/i-PRF added. Rese…

This study tested whether a gel made from rosemary extract could help treat periodontitis, a serious gum infection. 48 adults with advanced gum disease received standard deep cleaning plus either the rosemary gel or a placebo. The goal was to see if the gel improved gum pocket de…

This study looked at whether non-surgical gum disease treatment could reduce inflammation and improve blood fat levels in young adults with severe periodontitis. Fifty participants (25 with gum disease and 25 healthy) were involved. Those with gum disease received deep cleaning a…

This study tested two daily-use mouth rinses containing chlorhexidine (CHX) plus either hydrogen peroxide or cetylpyridinium chloride against a placebo rinse. Over 3 months, 81 adults used the rinse twice daily alongside normal brushing. Researchers measured plaque buildup, gum i…

This completed trial tested a new bone substitute called ALBO-OS in 20 people with periodontitis (severe gum disease) or needing jawbone preservation after tooth extraction. The material was placed into deep gum pockets or empty tooth sockets to help new bone grow. Early results …

This study tested whether a hyaluronic acid gel or a chlorhexidine mouthwash works better as a follow-up home treatment after deep cleaning for gum disease. Forty adults with periodontitis used one of the two products for 15 days after their dental cleaning. Researchers measured …

This study tested a new material called Mucoderm, made from donated animal tissue, to treat receding gums. It compared it to the standard treatment, which uses a small piece of tissue from the patient's own palate. The goal was to see if Mucoderm could cover exposed tooth roots j…

This study tested whether a new Colgate toothpaste with dual zinc can better control plaque and gingivitis (gum inflammation) compared to a standard cavity protection toothpaste. 86 adults with mild to moderate plaque and gum issues used one of the two toothpastes for three month…

This study compared a stannous fluoride toothpaste paired with a newly designed toothbrush to a standard toothpaste and brush for reducing plaque and gingivitis (gum inflammation). 95 adults with mild to moderate gum issues used their assigned products for 3 months. Researchers m…

This study tested whether a special dental care routine (PerioGard) works better than standard products for reducing plaque and gum inflammation. Eighty adults with mild to moderate gingivitis used either the PerioGard regimen or a regular fluoride toothpaste and mouthwash for th…

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash and a manual toothbrush reduces dental plaque and gingivitis better than using regular fluoride toothpaste with a standard toothbrush. Eighty-two adults with mild gum di…

This study tested whether a single dental visit for regenerative root canal treatment works as well as the usual two-visit approach for mature teeth with chronic infection. Thirty-two adults received either a one-session or two-session procedure, and researchers tracked pain duri…

This study tested a home-use device that uses dual-light therapy and a special mouth rinse to help control chronic gum disease. Fifty-six adults with advanced periodontitis used the device regularly. The goal was to see if it reduces gum bleeding and improves plaque control, whic…

This completed Phase 2 study enrolled 84 adults with mild to moderate plaque and gingivitis. Participants were randomly assigned to use one of two manual toothbrush and toothpaste regimens at home for 6 weeks. Dentists measured plaque and gum inflammation at 1, 3, and 6 weeks to …

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash can improve gum health and reduce plaque buildup better than using regular fluoride toothpaste alone. About 199 adults with mild gum disease (gingivitis) took part. Rese…

This study tested whether adding ozonated olive oil gel or curcumin gel to standard deep cleaning helps treat gum disease (stage II grade B periodontitis). Forty adults completed the 3-month trial. Researchers measured gum attachment levels, plaque, and inflammation to see which …

This study tested whether applying hyaluronic acid gel after gum surgery helps the gums heal better. 26 patients with deep gum pockets were randomly given either the gel or a saltwater placebo during surgery. Researchers measured healing, pocket depth, and patient comfort over 3 …

This study tested two different materials for gum grafting in 14 adults with stage 3 gum disease. One material came from the patient's own gum tissue, the other from a donor membrane. The goal was to see which helped gums heal better by measuring pocket depth and attachment level…

This study looked at whether making a larger opening at the tip of the tooth root helps regenerative dental treatment work better for adults with infected mature teeth. 36 people received one of two treatment sizes and were followed for healing and pain. The goal was to see which…

This study looked at whether deep cleaning of the gums (non-surgical periodontal therapy) could reduce prostate-specific antigen (PSA) levels and urinary tract infections in men with both gum disease and chronic prostatitis or recurrent UTIs. Sixty men were split into three group…

This study tested a new ultrasonic device with root polishing against standard scaling and root planing for treating gum disease. Forty adults with moderate to severe gum disease were treated and followed for 6 months. The goal was to see which method better reduced pocket depths…

This study looked at whether adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning helps treat gum disease. Twenty adults with deep gum pockets and bleeding were treated on both sides of the mouth—one side got the light therapy, the other d…

This study tested a new, less invasive surgery for receding gums. 24 adults with gum recession received a procedure using a donated tissue graft placed through a small tunnel under the gum. The goal was to cover exposed tooth roots and improve gum health. Results showed the treat…

This study tested two different lasers (Nd:YAG and diode) for treating stage II gum disease. Thirty-three adults with deep gum pockets received one of the laser treatments or standard care. Researchers measured bacteria levels and gum health to see which approach worked best.

This study tested two different places to take gum tissue for grafting—the back of the mouth (tuberosity) or the roof of the mouth (palate)—to fix receding gums on a single tooth. Thirty healthy adults with gum recession received one of the two grafts along with a gum-lifting pro…

This study looked at whether a toothpaste made from black seed (Nigella sativa) can lower signs of gum inflammation in 100 Indonesian soldiers with gingivitis. Researchers measured certain proteins in saliva that are linked to gum disease. The goal was to see if this toothpaste c…

This study looked at whether using a patient's own blood product (L-PRF) can improve bone healing after surgery for a persistent tooth-root infection. Fifteen adults with large infections around the tooth root were treated and followed for 12 months. The goal was to see if adding…

This study tested whether adding a hyaluronic acid gel to standard gum surgery (coronally advanced flap) helps treat type 1 gum recession. Twenty adults with gum recession on both sides of the mouth took part. The gel aims to improve gum coverage and reduce discomfort. Results we…

This study tested whether adding laser therapy to standard deep cleaning improves gum health in people with severe periodontitis. Twenty adults received either antimicrobial photodynamic therapy (using a blue dye and laser) or photobiomodulation (red or infrared laser) alongside …

This study tested whether a mouthwash made from Triphala, an Ayurvedic herbal formula, works as well as the standard chlorhexidine mouthwash for reducing plaque and gum inflammation. 220 adults with mild to moderate gingivitis used one of the two mouthwashes twice daily for 30 da…

This study tested whether a licorice extract gel could improve the results of deep cleaning for people with stage II periodontitis (moderate gum disease). Fifty patients were split into two groups: one got standard deep cleaning alone, and the other got deep cleaning plus licoric…

This study compared two surgical techniques to treat receding gums: the pinhole technique and the tunnel technique. 21 adults with gum recession received both procedures on different teeth. The goal was to see which method better covered exposed roots and increased gum thickness …

This study tested whether a mouthwash made from guava leaf extract can reduce plaque and gum inflammation as well as a standard chlorhexidine mouthwash. 160 adults with chronic gingivitis rinsed twice daily for up to 90 days. Researchers measured plaque buildup and gum health to …

This study tested whether a gel made from patients' own blood, called albumin platelet-rich fibrin (Alb-PRF), can improve gum healing after deep cleaning for advanced gum disease. Twenty-three adults with Stage 3 periodontitis received the gel in deep gum pockets on one side of t…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study involved 24 adults with receding gums to see if adding an enamel protein to a standard gum graft procedure improves results. The standard method uses a tissue graft placed under the gum with a small tunnel. Half the participants also got the enamel protein. Researchers…

This study tested whether adding ozone gas to standard deep-cleaning treatment helps people with gum disease (periodontitis). 18 healthy, non-smoking adults received standard cleaning on one side of the mouth and cleaning plus ozone on the other side. Researchers measured pocket …

This study tested whether platelet-rich fibrin (PRF), made from a patient's own blood, can improve gum and bone regeneration after standard periodontal surgery. Sixty adults with chronic gum disease and bone defects were randomly assigned to surgery alone or surgery plus PRF. Res…

This study tested whether using a special toothpaste and mouthwash together with a manual toothbrush works better than regular fluoride toothpaste alone for reducing plaque and improving gum health. 90 adults with mild to moderate gum problems brushed twice daily for 12 weeks. Re…

This completed Phase 3 study tested whether a battery toothbrush paired with a stannous fluoride toothpaste is more effective at reducing plaque and gingivitis than a regular fluoride toothpaste with a manual toothbrush. 130 adults with mild gum disease brushed twice daily for 12…

This study tested whether a probiotic called TCI188 (Pediococcus acidilactici) can improve oral health in adults with serious gum disease. Fifty-five participants took either the probiotic or a placebo daily. Researchers measured gum pocket depth and bleeding to see if the probio…

This study tested whether adding omega-3 fish oil and low-dose aspirin to standard deep-cleaning treatment helps smokers with severe gum disease. Forty-five smokers were split into three groups: one got omega-3 and aspirin, another got those plus the antibiotic doxycycline, and t…

This study tested whether adding hyaluronic acid to a standard chlorhexidine mouthwash helps treat gingivitis (gum inflammation). Sixteen adults with gingivitis used two different mouthwashes after a professional teeth cleaning. Researchers measured bleeding and plaque levels to …

This study tested whether a special light device used at home can improve oral health in teenagers with braces. Forty teens used the device daily for two months, while others received standard brushing instructions. The goal was to see if the device reduces plaque and gum bleedin…

This study looked at whether a root canal for an infected tooth with an abscess can be done in one visit instead of two. Fifty-nine adults received either a single-visit treatment or a two-visit treatment with a calcium hydroxide medication placed in between. After 12 months, bot…

This study tested a light-activated treatment called Fotosan®630 for severe gum disease (periodontitis). The goal was to see if it could reduce deep gum pockets and infection better than standard care. The trial involved 36 adults with severe chronic periodontitis and followed th…

This study tested whether an experimental toothpaste with stannous fluoride, zinc chloride, and alumina can improve gum health better than a regular fluoride toothpaste. 175 adults with mild to moderate gingivitis used the toothpaste for 4 weeks. Researchers measured gum bleeding…

This study tested whether a medical glue (butyl-cyanoacrylate) works as well as traditional stitches for holding gum grafts in place. Twenty-four adults with thin gums received either glue or stitches after graft surgery. Researchers tracked healing, graft size, patient comfort, …

This study tested whether a toothpaste with stannous fluoride can improve gum health better than a regular fluoride toothpaste. 154 adults with mild gum inflammation (gingivitis) used one of the two toothpastes for 12 weeks. Researchers measured gum bleeding and plaque to see whi…

This study tested if a special light device used at home can help manage chronic periodontitis, a serious gum infection. 202 adults with gum disease used the device regularly to see if it reduced bleeding and improved gum health. The goal was to offer an easy, non-invasive way to…

This study tested three treatments for multiple receding gums in 60 healthy adults. It compared a collagen matrix, platelet-rich fibrin, and a connective tissue graft to see which covers exposed tooth roots best. The goal was to improve gum health and appearance.

This study tested three different medications placed inside the tooth root after cleaning to see which one works best for reducing pain, fighting bacteria, and helping bone heal. 45 adults with a single infected tooth took part. The medications compared were N-acetylcysteine, cal…

This completed trial tested two surgical procedures to reduce a gummy smile (excessive gum display when smiling). Sixteen women aged 18 to 30 received either a modified lip repositioning surgery or a Z-plasty frenectomy. Researchers measured how much the gum show decreased, pain …

This small pilot study tested a new way to treat dead (necrotic) teeth in 6 adults. Doctors took pulp tissue from a healthy donor tooth, mixed it with a growth factor concentrate (CGF), and transplanted it into the dead tooth. After 12 months, they checked if the tooth regained f…

This study tested a new combination treatment for gum disease-related bone loss. Thirty adults with deep gum pockets received a graft made from zinc-substituted nano-hydroxyapatite (a bone-like material) mixed with advanced platelet-rich fibrin (a blood-derived healing scaffold).…

This study tested whether adding enamel matrix proteins (Emdogain) and a bovine bone graft to a minimally invasive gum surgery (M-MIST) helps heal deep gum defects better than surgery alone. Forty-five adults with at least one deep gum pocket were treated and followed. The main g…

This study tested whether injecting a substance made from a patient's own blood, called injectable platelet-rich fibrin (i-PRF), can improve gum healing after a deep dental cleaning. Twenty adults with advanced gum disease received i-PRF on one side of their mouth and a saltwater…

This study tested two surgical techniques for fixing receding gums in 50 adults aged 18-35. Both methods used a coronally advanced flap, but one added a platelet-rich fibrin membrane and the other a chorion membrane. The goal was to see which better reduces gum recession and impr…

This study tested three ways to clean infected root canals in 97 people with large tooth infections. The methods were manual movement, ultrasonic vibration, and laser activation. Researchers measured how much the infection shrank over one year using 3D scans. The goal was to find…

This study tested whether adding a 980nm diode laser to standard deep-cleaning gum treatment improves gum health and reduces body-wide inflammation in people who recently had a heart attack. Forty participants with gum disease (some healthy, some heart attack survivors) received …

This study tested whether splitting deep cleaning into three sessions works better than doing it all at once for people with severe gum disease. 48 non-smoking adults with advanced periodontitis were randomly assigned to one of the two cleaning methods. Researchers checked gum he…

This study tested three methods to preserve the jawbone after removing an infected front tooth. Fifty-four adults received either a dentin graft alone, a dentin graft with a special platelet-rich fibrin (PRF) mix, or a dentin graft with PRF plus an antibiotic. The goal was to see…

This study looked at whether treating gum disease (periodontitis) can improve blood sugar control in people with diabetes. 91 patients were randomly assigned to receive either gum treatment or no treatment (with treatment offered later). The main measure was change in hemoglobin …

This study tested three different materials (blood clot, platelet-rich fibrin, and concentrated growth factor) combined with two types of rinses to help regrow root tissue in 30 immature permanent teeth with dead nerves. Participants aged 9 to 25 were followed for 12 months using…

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 adults with RA and gum disease, providing periodontal treatment and measuring changes in RA activity …

This completed study tested whether a new herbal mouthwash and gel (StellaLife) works as well as the standard chlorhexidine mouthwash for treating gingivitis (early gum disease). 34 healthy adults without gum disease took part. The goal was to see if StellaLife can control plaque…

This study tested a new mouthwash containing CPC, hyaluronic acid, and zinc lactate against a standard fluoride mouthwash. The goal was to see if it reduces plaque and prevents gum problems in adults with at least two dental implants. Eighty participants used the mouthwash for si…

This study tested two mouthwashes—one with 0.12% chlorhexidine and another with a lower dose of chlorhexidine plus cetylpyridinium chloride—to see which better controls gum inflammation and bacteria in people with gum disease. 72 adults used one of the rinses for a month after a …

This study tested a mobile app called NutriDent4Mom in 264 pregnant women to see if it could improve their diet and gum health. Half the women used the app to track food and read health tips, while the other half received standard care. The app was designed to help women meet nut…

This study looked at whether using a piece of a patient's own tooth can help repair bone gaps around new dental implants placed right after a tooth is pulled. 63 adults aged 20 to 45 with a damaged front tooth were treated. Some got the standard implant, some got an extra tooth g…

This study tested whether placing a thin bone layer (cortical lamina) over the extraction site helps preserve the jawbone's shape and size. Forty adults needing a tooth pulled were randomly assigned to get the lamina or standard care. After six months, bone changes were measured …

This study tested whether a hyaluronic acid gel (HyaDent BG) works as well as Emdogain, a standard treatment, for repairing bone defects caused by gum disease. Both were used with a bone graft material during surgery. Seventeen adults with advanced periodontitis took part. The go…

This study tested a gum surgery that combines a connective tissue graft with a special protein gel (enamel matrix derivative) to help regrow bone and gum tissue in people with advanced gum disease. Seventeen adults with deep gum pockets received the treatment, and researchers mea…

This study tested whether natural gels (curcumin and nanocurcumin) or synthetic gels (ciprofloxacin with ibuprofen) placed inside a tooth between retreatment visits can help heal infections better than the standard calcium hydroxide paste. Sixty adults with failed root canals and…

This study tested how well floss and three different mouthwashes (one with essential oils and alcohol, one with essential oils but no alcohol, and one with CPC+Zn and no alcohol) reduce plaque and gum inflammation. 228 adults with mild to moderate gum disease took part. The goal …

This study tested whether adding a diode laser to standard deep cleaning helps smokers with severe gum disease. 33 smokers were split into two groups: one got standard cleaning alone, the other got cleaning plus laser. After 3 months, the laser group had shallower gum pockets, le…

This study tested whether a gel made from patients' own blood (injectable platelet-rich fibrin, or i-PRF) could improve healing after standard gum surgery for periodontitis. 42 adults with deep gum pockets received surgery alone or surgery plus i-PRF and a root-cleaning gel. Rese…

This study tested whether a special oral appliance called myTAP, combined with a mouth shield and deep dental cleaning, can reduce gum disease in people who snore and breathe through their mouth. 43 adults with mild to moderate gum disease completed the 12-week trial. The device …

This study tested two antibiotic gels (metronidazole and minocycline) in 380 adults with both diabetes and gum disease. Participants received deep cleaning alone or with one or both gels. Researchers checked gum pocket depth and gum color/texture at 7 and 15 days to see which tre…

This study tested whether taking a daily probiotic (Bifidobacterium Lactis HN019) can reduce plaque buildup and gum bleeding in people undergoing orthodontic treatment with braces or clear aligners. Sixty participants, aged 10 to 30, took the probiotic or a placebo for a period w…

This study tested two deep-cleaning methods for gum disease (periodontitis) in 36 adults: a water-and-powder spray (Airflow®) and traditional hand scraping. Researchers measured gum bleeding, pocket depth, and signs of inflammation in mouth fluid to see which method causes less t…

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This study tested whether lozenges made from propolis (a substance bees produce) can improve gum health in 100 young adults with mild to moderate gingivitis. Participants chewed the lozenges twice daily for a week while keeping their normal brushing routine. Researchers measured …

This study tested two treatments for deep gum bone defects caused by periodontitis: platelet-rich fibrin (PRF), made from the patient's own blood, and enamel matrix derivative (EMD), a protein gel. Twenty-six patients received one of the treatments after surgery, and their gum he…

This study tested whether using a mouthwash with cetylpyridinium chloride (CPC) along with regular brushing improves gum health and reduces plaque more than brushing alone. 136 adults with mild to moderate gingivitis used either the CPC mouthwash or just brushed with fluoride too…

This study tested a new mouth rinse made with coconut oil and xylitol to see if it could improve gum health in people with periodontitis. 120 adults used the rinse or a placebo three times a day for three weeks. Researchers measured gum appearance and bleeding before and after us…

This completed study tested a surgical technique called Entire Papilla Preservation (EPPT) alone or with added enamel matrix derivative and bone graft for repairing bone defects from gum disease. Fifty-eight adults with moderate to severe periodontitis took part. The goal was to …

This study compared interdental brushes and rubber bristle cleaners in 40 adults with gingivitis (early gum disease). Participants used one of the two tools for four weeks. Researchers measured plaque removal and gum bleeding, and also asked about satisfaction. The goal was to se…

This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in their gum health and tooth appearance. 460 smokers with mild gum disease were randomly assigned to keep smoking, switch to these products…

This study tested whether a gentler, magnified cleaning method (MINST) works better than standard deep cleaning for treating early gum recession. Fifty-four adults with shallow gum recession (3 mm or less) took part. The goal was to see if MINST could reduce recession depth and w…

This study tested a special dental floss coated with a probiotic (good bacteria) to see if it could reduce harmful mouth germs and improve gum health. Thirty-three healthy men used the probiotic floss and a placebo floss for two weeks each, with a break in between. Researchers me…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

This study tested a new high-frequency ultrasound probe to measure the depth of gum pockets, a key sign of periodontal disease. Researchers compared the ultrasound measurements to standard manual probing in 39 adults. The goal was to see if the ultrasound could accurately detect …

This study tested a non-invasive optical device that uses different types of light to detect and diagnose various mouth conditions, including oral cancer, gum disease, and dry mouth. Over 1,000 participants with and without oral lesions were imaged, and the results were compared …

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study compared a mobile app (Peribrain) to traditional manual methods for classifying the stage and grade of periodontitis (gum disease) in 122 patients. A student, a clinical student, and a clinician each classified the disease using either the app or manual measurements. T…

This study looked at whether measuring a substance called pentraxin in the fluid around teeth can help detect early gum disease in people who have fixed dentures. Researchers studied 90 patients to see if pentraxin levels could reveal inflammation that isn't visible during a regu…

This study looked at whether certain proteins and metals in saliva can signal the start of gum disease before teeth are damaged. Researchers measured these markers in 106 adults with healthy gums or various stages of gum disease. The goal was to find a way to predict gum disease …

This study tested a procedure called Periodontally Accelerated Osteogenic Orthodontics (PAOO) in 20 adults getting braces. The goal was to see if it could prevent bone loss and gum recession on the front of the lower teeth. The procedure combines a small cut in the gum with a bon…

This study tests whether a personalized teaching method called 'Touch-to-Teach' helps people with stage II periodontitis clean between their teeth better than standard instructions. Forty participants will be split into two groups: one gets standard care, the other gets the new m…

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the …

This study tested two methods to help gums heal after a gingivectomy (removing excess gum tissue). Sixty-four healthy adults received either a hyaluronic acid spray (applied twice daily for 7 days) or low-level laser therapy (applied 4 times over 7 days). Researchers measured wou…

This study tested whether a new mouthwash can reduce dental plaque and help prevent gum problems better than a control mouthwash. 80 adults with mild to moderate gum inflammation and plaque used the product for three months. Researchers measured gum health and plaque levels at 2 …

This study tested whether ozonized gel or a special laser helps gums heal faster and with less pain after a gingivectomy (gum removal surgery). 48 adults received one of the two treatments or standard care. Researchers checked healing, pain, and tissue regrowth over 28 days. The …

This study tested two ways to clean teeth and gums in 82 people with poorly controlled type 2 diabetes and severe gum disease. One method cleaned all teeth in one day (full mouth disinfection), while the other cleaned one quarter of the mouth at a time over four weeks. Researcher…

This study looked at whether a deep dental cleaning (called subgingival instrumentation) can reduce jaw symptoms like pain, stiffness, and tension in people who grind their teeth (bruxers) and also have gum disease (periodontitis). Sixty adults aged 30-40 received the cleaning, a…

This study tested a more precise dental surgery for people with persistent root infections after standard treatment. Using a 3D-printed guide, surgeons aimed to remove infected tissue more accurately, reduce surgery time, and improve quality of life. The trial involved 70 adults …

This study tested whether taking a specific probiotic (Limosilactobacillus reuteri) can improve gum health in adults with braces who also have gingivitis (gum inflammation). One hundred participants either received the probiotic or no supplement. Researchers measured gum bleeding…

This study tested two mouthwashes—a standard antiseptic (chlorhexidine) and a new one (MicroRepair ABX)—in 40 adults with gingivitis (gum inflammation). After a professional cleaning, participants used their assigned mouthwash twice daily for 14 days. Researchers measured gum ble…

This study tested whether using different modes on an electronic apex locator (a tool that measures tooth canal length) during root canal retreatment could reduce pain afterward. 144 adults with infected teeth were split into four groups: one used a standard locator, and three us…

This study looked at how satisfied patients were and how much pain they felt after getting All-on-Four dental implants under sedation. 30 adults were followed for three days after surgery. Researchers measured pain, swelling, and how much pain medicine they used. The goal was to …

This study looked at whether applying ozone gas to surgical wounds in the mouth can help gums heal faster after gum surgery. Twenty-four people with enlarged gums due to chronic inflammation took part. Each person had two similar areas treated: one with standard surgery alone, an…

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study tested a custom 3D-printed PEEK shell placed under the gum in the upper jaw to reduce excessive gum display (gummy smile) in 10 patients. The shell was inserted through small incisions using a tunnel technique. The goal was to see if it could decrease the amount of gum…

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

This study tested two different tools—a magnetic mallet and a piezotome—to widen a thin upper jawbone so dental implants could be placed. Twenty patients with missing front teeth and narrow bone received the procedure along with a bone graft. The goal was to see which tool gave b…

This study looked at 168 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if different root canal shaping tools affect pain after the procedure. Participants received one of four shaping methods, including using a single file or combining files. The…

This study looked at how comprehensive gum treatment affects chewing ability and quality of life in people with severe gum disease (Stage III periodontitis). Twenty patients with gum disease and twenty healthy people took part. Patients received deep cleaning and, if needed, gum …

This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain wa…

This study tested a device called EDDY that uses sound waves to clean root canals better. Forty adults with infected teeth but no pain were treated. The sonic cleaning killed more bacteria than standard methods, but it did not reduce pain after the procedure compared to usual car…

This study tested whether applying cold therapy (cryotherapy) inside the mouth or inside the tooth itself can reduce pain and inflammation after root canal treatment. Thirty adults with painful tooth infections received either an oral cold pack, a cold saline rinse inside the too…

This study looked at 88 healthy adults with infected teeth to see if different irrigation methods during root canal treatment affect pain afterward. Participants had a tooth with a chronic infection and received one of several irrigation techniques. The goal was to find which met…

This study tested a procedure called full pulpotomy (removing only the infected pulp inside the tooth crown) in 58 adults with severe toothache. It compared success in teeth with and without an infection at the root tip (apical periodontitis), using an AI tool to help detect the …

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study tested two ways to protect gums during in-office teeth whitening: relative isolation (using a tray) and absolute isolation (covering gums completely). Thirty healthy adults with no cavities or gum disease took part. Researchers checked for gum irritation, tooth sensiti…

This study looked at 30 adults with braces and gum inflammation (gingivitis). Each person received two different cleanings—one side of the mouth got a newer method called Guided Biofilm Therapy (using air and powder), and the other side got the standard ultrasonic cleaning and po…

This study tested whether using an air-polishing device with erythritol powder is as effective as standard scaling and root planing for maintaining gum health after initial treatment. Twenty adults with periodontitis were randomly assigned to one of the two cleaning methods. The …

This study looked at three different root canal sealers to see if any caused less pain or helped teeth heal faster. Seventy-two adults with infected single-rooted teeth received standard root canal treatment with one of the sealers. Pain was checked right after, at 24 hours, and …

This study looked at whether using sonic irrigation or a diode laser during root canal treatment reduces pain afterward. Eighty adults with infected single-rooted teeth were randomly assigned to one of four cleaning methods. Patients reported their pain levels and painkiller use …

This study tested whether non-surgical gum treatment can improve smell and reduce tongue coating in adults with periodontitis. 108 non-smoking participants had their smell tested before and three days after treatment. The goal was to see if treating gum disease leads to short-ter…

This study tested two treatments—ozonated gel and titanium platelet-rich fibrin (T-PRF)—on 39 people to see which helps palatal wounds heal better after gum graft surgery. Participants were followed for 14 days to measure pain and wound size. The goal is to find a simple way to r…

This study tested whether adding a substance made from the patient's own blood (L-PRF) to standard gum surgery improves healing and reduces pain. Twenty-one adults with gum disease had both types of surgery on different sides of their mouth. Researchers measured pocket depth and …

This study tested whether placing stitches (pre-sutures) in the roof of the mouth before taking a gum graft can reduce bleeding and pain. 32 adults with gum recession took part. Researchers measured blood loss, pain, and healing after surgery. The goal was to see if this simple s…

This study tested two different materials—surgical glue and ferric sulfate—to control bleeding during root-end surgery in 34 patients with infected tooth roots. Researchers measured how well each agent stopped bleeding, how much pain patients felt afterward, and their quality of …

This study looked at five different methods for cleaning infected root canals in 132 people with large tooth infections. The goal was to see which technique helps the infection heal best by reducing the size of the infection site on X-rays. The methods included manual cleaning, u…

This study tested whether adding injectable platelet-rich fibrin (i-PRF) and low-level laser therapy to standard gum graft surgery could reduce the amount the graft shrinks during healing. Gum grafts are used to cover exposed tooth roots, but they often shrink over time. The stud…

This study tested whether adding a special laser treatment (photodynamic therapy) to standard gum cleaning could reduce bad breath. Forty adults with gum disease and self-reported bad breath received full-mouth scaling plus a laser-activated gel on their tongue and deep gum pocke…

This study looked at ways to reduce tooth sensitivity after deep cleaning for gum disease. 48 adults with sensitive teeth received either a desensitizing gel (Gluma), a special laser, or both. Their pain was measured over 6 months. The goal was to see if combining treatments work…

This study looked at 70 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if the type of sealer used during root canal treatment affects pain afterward. Participants received either a bioceramic sealer (BioRoot RCS) or a resin-based sealer (AH Plus) …

This study tested a full-mouth electronic toothbrush (FMET) to see if it reduces gum inflammation and plaque better than a regular electronic toothbrush. 94 adults with mild to moderate gingivitis used either the FMET, a conventional electronic toothbrush, or the FMET with a spec…

This study tested two surgical methods to reduce a gummy smile in 20 adults aged 18-38. One method was the standard lip repositioning, the other a modified technique that also controls a specific lip muscle. The goal was to see which approach reduces gum show more effectively and…

This study tested whether low level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani patients aged 18-30 received either standard braces or braces plus laser treatment on their front teeth every three we…

This study looked at 42 adults with infected single-rooted teeth to see if using sonic or ultrasonic tools to clean the root canal helps the tooth heal better than the standard method. Participants got one of three cleaning techniques during their root canal, and the size of the …

This study tested whether a water flosser is better than an interdental brush at removing plaque and reducing gum inflammation in people with braces. 75 adults with braces used both tools on different sides of their mouth for 3 months. The goal was to see which tool cleans better…

This study tested a program where care partners helped people with mild dementia brush their teeth better. The program included a personalized oral care plan and tips for communication and cueing. Researchers measured plaque and gum health in 60 participants. The goal was to prev…

This study tested two ways to remove extra gum tissue (gingival hyperplasia) in people with braces: using a surgical scalpel or a diode laser. Thirteen adults with fixed braces and gum overgrowth took part. The goal was to see which method led to better healing, less pain, and im…

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study looked at 120 adults needing a root canal to see if one sealer (AH Plus or WellRootST) causes less pain afterward. Pain was checked before treatment and at several points up to one month later. The goal is to help dentists choose the better option for patient comfort.

This study looked at how satisfied people were with at-home tooth bleaching using two different types of orthodontic retainers. Forty adults who had finished Invisalign treatment used both retainer designs and rated their experience. The goal was to see if one design caused less …

This study tested whether a special 5-day fasting-mimicking diet (plant-based soups, bars, and drinks) could reduce inflammation after deep cleaning for advanced gum disease. Twenty-eight adults with stage III-IV periodontitis were randomly assigned to either follow the diet or e…

This study tested whether a specific routine—using a power toothbrush and mouth rinse twice daily—reduces gum bleeding and inflammation better than a manual toothbrush alone. 69 adults with gingivitis participated for 6 weeks. Researchers measured gum health at the start and afte…

This study tested how satisfied people are with at-home teeth whitening using two different types of trays: Vivera and Essix. Forty adults with healthy teeth used a 10% carbamide peroxide gel for 2 hours a day, 3 days a week, for 4 weeks with each tray. Researchers measured satis…

This study tested whether using 3D-guided microsurgery helps bone heal better after a failed root canal compared to standard surgery. It also compared two different filling materials: a newer bioceramic putty and the standard MTA. Twenty-four adults with persistent infections aft…

This study tested whether using a sonic device (EndoActivator) to clean the tooth during a root canal reduces pain afterward. Fifty-eight adults with tooth infections were randomly assigned to get either the sonic cleaning or standard syringe irrigation. Pain was measured before …

This study looked at a modified lip repositioning surgery for people with a gummy smile (too much gum showing when smiling). The surgery was done without removing gum tissue or cutting a lip muscle. Researchers reviewed records and photos of 32 patients who had the procedure. The…

This study tested whether a toothpaste and mouthwash made with biomimetic hydroxyapatite could reduce tooth sensitivity in 100 adults with receding gums. Participants had one 30-second application of either the toothpaste or mouthwash in a clinic. Sensitivity was measured before …

This study tested whether a rinse called octenidine reduces pain after root canal treatment better than the standard rinse chlorhexidine. 142 adults with a single-rooted tooth and asymptomatic apical periodontitis received one of the two rinses during their procedure. Pain was re…

This study looked at how vaping and traditional smoking affect gum healing after a deep dental cleaning in people with stage II gum disease. Researchers measured gum pocket depth, bleeding, and inflammation markers in 117 participants. The goal was to see if vaping is less harmfu…

This study tests whether wearable sensors and digital home tasks can track changes in movement, speech, and falls in people with ALS. About 20 participants will wear neck and wrist sensors and complete speech and handwriting tests over 48 weeks. The goal is to see if these digita…

This study followed 55 people with dental implants for 5 years to see if their history of gum disease (aggressive, chronic, or none) affected implant health. Participants received regular dental cleanings. Researchers measured bone loss, gum inflammation, and implant survival. Th…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study looked at 76 children aged 3 to 15 getting dental care with nitrous oxide (laughing gas). Researchers watched for signs that kids wanted to keep the mask on longer, like hand gestures or asking to keep it. The goal was to see if there's a risk of children misusing the …

This completed study looked at how oral health problems like cavities and gum issues affect the daily lives of 454 preschool children in Portugal. Researchers asked parents about their child's oral health and its impact on the child and family. The goal was to understand which so…

This pilot study looked at bacteria in root canal infections, comparing painful and painless cases. Researchers used DNA testing to identify bacteria before and after cleaning with two different strengths of sodium hypochlorite. The goal was to see how well the cleaning removes b…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study examined 180 adults to see if the shape of their gums and their oral habits (like brushing force or teeth grinding) are linked to non-carious cervical lesions — wear on teeth not caused by cavities. Participants filled out a questionnaire and had a dental exam. The goa…

This study looked at how the types of bacteria in an infected root canal change during routine dental treatment. Twenty-four adults with a chronic tooth abscess received standard root canal therapy using one of two bleach solutions (5.25% or 3% sodium hypochlorite) followed by a …

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study followed 130 adults with advanced gum disease (periodontitis) to see if those who used probiotics on their own during standard non-surgical treatment had better outcomes. Researchers measured plaque, bleeding, pocket depth, and quality of life at 1 and 3 months. The go…

This study looked at how diet affects gum inflammation in healthy people. Researchers compared vegans and omnivores by temporarily stopping their oral hygiene to see how their gums reacted. The goal was to understand if a vegan diet might reduce gum inflammation compared to an om…

This small study tested two methods for cleaning infected root canals: ultrasonic activation and a 980-nm diode laser. Sixteen adults with dead (necrotic) teeth had their root canals cleaned with one of these methods. Researchers checked for leftover bacterial DNA to see which me…

This study translated a questionnaire that measures how chronic gum disease affects quality of life into Hindi. Researchers tested it on 196 patients with periodontitis to ensure it is accurate and reliable. The goal is to give Hindi-speaking patients a way to report their oral h…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This study looked at whether a natural antioxidant marker in gum tissue can help tell how severe gum disease (periodontitis) is. Researchers measured levels of thioredoxin reductase 1 and other markers in gum samples from 60 healthy people and patients with different stages of gu…

This study looked at immune cells in a non-cancerous gum growth called peripheral giant cell granuloma (PGCG) and compared them to healthy gum tissue from the same 28 patients. Researchers used special staining to count different types of immune cells. The goal was to better unde…

This completed study looked at how a specific inflammation trigger (NLRP3) relates to different stages of gum disease and aging-related inflammation. Researchers measured NLRP3 levels in fluid from the gums of 80 participants with various stages of periodontitis and healthy indiv…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study tested a new lab method (xCELLigence system) to grow oral biofilms and select the most effective antibiotic for each patient with chronic periodontitis. 64 adults with severe gum disease received standard deep cleaning plus an antibiotic chosen by the new test. The goa…

This pilot study tested two different bone grafting methods for people needing dental implants after tooth loss. Forty implants were placed in 21 patients, using either a collagen-based graft alone or a mix of synthetic bone and the patient's own bone. Both methods used a special…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people with obesity and gum disease (stage II or III). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link betw…

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor ora…

This study looked at how gum tissue heals when taken from two different areas of the palate (roof of the mouth) to treat receding gums. Forty healthy adults aged 20-40 had a gum graft taken either from the front or back of the palate. Using 3D scans, researchers measured volume c…

This small pilot study tested a new way to place dental implants in the upper jaw when there is not enough bone height. Surgeons used a special drill and a tiny camera to watch the sinus membrane during the procedure. The goal was to see how often the membrane gets torn, which ca…

This study tested whether custom-made orthodontic molar bands, created using digital scans and 3D printing, lead to better gum health than standard pre-made metal bands. 180 teenagers getting braces were randomly assigned to one type of band. Researchers checked plaque buildup, g…

This study measured how often adults with gum disease have atypical swallowing (abnormal tongue movements). Researchers checked 125 adults for tongue posture and other mouth signs. The goal was to see if this swallowing pattern is linked to worse gum problems.

This study looked at 120 adults to see if anxiety and depression are linked to a common tooth infection called apical periodontitis. Participants had dental exams and filled out questionnaires about their mental health. The goal was to better understand how emotional well-being a…

This study tested two types of special membranes used to help grow new jawbone in areas where bone has been lost. Fourteen people who needed bone rebuilding before getting dental implants took part. Researchers measured how much bone grew over 12 months using 3D X-rays and checke…

This study looked at whether injecting a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) could help heal teeth with chronic infection at the root. Sixty adults with infected teeth received standard root canal treatment; half also got the i-PR…

This study examined fluid from deep gum pockets in 30 people with severe periodontitis, both smokers and non-smokers. Researchers measured 40 inflammatory markers before and after non-surgical deep cleaning. The goal was to see which markers change with treatment and whether smok…

This completed study looked at 61 adults to see if physical fitness, body composition, and diet are linked to gum disease severity. Researchers reviewed dental records and lifestyle questionnaires from a previous study. No new treatments were tested; the goal was simply to unders…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This study examined how standard non-surgical gum disease treatment changes the jaw bone structure in 69 people with gingivitis or periodontitis. Researchers used fractal analysis of dental X-rays taken before and 6 months after treatment to detect subtle bone changes. The goal i…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study tested a French version of the Oral Health Impact Profile (OHIP) questionnaire, which measures how oral health affects daily life. Researchers enrolled 200 French-speaking adults, including people with gum disease and healthy controls. Participants filled out the quest…

This study aimed to create a computer model that can predict which gum disease treatment will work best for each person. Researchers looked at dental records from 86 patients, including gum measurements, X-rays, and personal details. The goal is to help dentists choose the most e…

This completed study looked at how radiation therapy for head and neck cancers affects viruses in the mouth, specifically the Epstein-Barr virus (EBV), and how this might relate to gum disease. Researchers collected samples from 25 patients to measure virus levels. The goal was t…

This completed study from Cairo University looked at whether people with multiple sclerosis (MS) are more likely to have gum disease. Researchers examined 293 Egyptian adults with MS using standard dental check-ups. The goal was to see if there is a link between MS and periodonta…

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The …

This study compared gum health and levels of inflammatory substances in the mouth and blood of 25 people with non-infectious uveitis (an eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and cytokines like TNF-α and IL-10. The goal was…

This study looked at whether bone grafts used before dental implants cause the body to make antibodies that might affect healing. Twenty healthy adults needing bone augmentation received either animal or human donor bone, and half also got laser therapy. Blood and bone samples we…

This study looked at how a toothpaste with sodium bicarbonate (baking soda) affects the bacteria living in the mouth over 12 weeks. Seventy-four adults with mild gum inflammation (gingivitis) used either the baking soda toothpaste or a regular fluoride toothpaste. Researchers che…

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study looked at 42 adults with advanced gum disease to see if stress hormones (cortisol and DHEAS) found in hair could measure the body's overall stress load. Researchers took hair samples and gave questionnaires at the start and 60 days after standard gum treatment. The goa…

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measure…

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. Th…

This study looked at 185 people to compare inflammation markers in those with tooth infections (apical periodontitis), gum disease (chronic periodontitis), and healthy gums. Researchers measured substances like TNF-α and PGE2 in blood and gum fluid. The goal was to better underst…

This study looked back at 126 patients who had gum regeneration surgery for severe gum disease. Researchers checked dental records and did a follow-up exam to see if the surgery helped close deep gum pockets and improve gum health. The goal was to understand how well these proced…

This observational study looked at 400 dental and medical students to see how their oral health affects their quality of life. Researchers measured plaque, gum health, and cavities, and asked students about their oral health-related well-being. The goal was to understand if diffe…

This study looked at 101 adults with gum disease and bad breath to see if treating the gums could also improve their sense of smell. Participants received standard deep-cleaning dental treatment. Researchers measured bad breath gases and smell function before and one week after t…

This completed study looked at 73 children aged 6-12 to see if sleep problems and certain chemicals in saliva are linked to cavities and gum health. Researchers measured things like saliva flow, pH, and stress hormones, and compared them to the severity of tooth decay. The goal w…

This study looked at whether adding einkorn, an ancient cereal, to the diet could change the types of bacteria in the mouth. Researchers focused on bacteria linked to gum disease and cancer risk. Thirty-one healthy adults ate einkorn and had their oral bacteria measured over time…

This completed study measured two immune proteins, IL-8 and IL-10, in fluid from the gums and around the tooth root during root canal treatment. Researchers wanted to see how these levels change as treatment progresses in people with infected, dead tooth pulp. Twenty-two adults a…

This study tested whether special cameras (2D and 3D) can measure swelling and temperature changes after gum surgery. 60 adults with gum disease had routine surgery, and the cameras tracked healing patterns. The goal was to see if this non-invasive method could help doctors monit…

This completed study looked at 51 people having surgery to remove plaque from their neck arteries. Researchers checked the plaque for oral bacteria and measured mitochondrial DNA. The goal was to see if mouth germs might play a role in artery disease. No treatment was given—it wa…

This completed study examined the mouth bacteria of 30 people, some with gastritis (stomach inflammation) and some without, to see if gum disease and stomach issues are connected. Researchers collected saliva samples and used advanced DNA technology to compare the types and amoun…

This study examined 95 adults with diabetes and gum disease to see if blood sugar control and gum disease severity are linked to changes in gum cells. Researchers looked at cell samples under a microscope for signs of damage. The goal was to better understand how these conditions…

This study looked at the oral health of 61 obese adults, comparing those who had bariatric surgery to those who did not. Researchers measured tooth wear, cavities, and gum disease to understand how surgery might affect the mouth. The goal was to gather information, not to test a …

This study tested whether a custom 3D-printed surgical guide helps dentists place bone grafts more accurately in the upper jaw compared to doing it free-hand. Thirty people with thin jawbones received bone taken from their chin. The main goal was to measure how much bone width an…

This pilot study looked at whether certain natural germ-fighting proteins, called antimicrobial peptides, are linked to chronic gum disease. Researchers collected gum smears from 29 adults with moderate to severe periodontitis and from healthy people to compare gene activity. The…

This study tested whether placing a gel made from a patient's own blood into the socket after wisdom tooth removal, along with low-level laser therapy, can improve healing. 122 adults had their impacted wisdom teeth removed and were assigned to different combinations of these tre…

This study followed 163 people who got dental implants between 1999 and 2005 to see how well the implants held up over time. Researchers checked patient satisfaction, implant survival, bone loss, and signs of inflammation. They also looked for risk factors that might lead to prob…

This completed study looked at 108 Turkish adults to see if understanding dental health information is linked to gum health. Participants took a reading test about dentistry and had a dental exam. The goal was to find out if people with lower health literacy have worse gum diseas…

This study looked at how smoking affects gum healing after non-surgical treatment for stage II gum disease. Researchers measured two proteins (PLAP-1 and Sclerostin) in the gum fluid of 36 patients—both smokers and non-smokers—before and after deep cleaning. The goal was to see i…

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study explored the connection between gum disease severity and levels of certain antibodies (ACPAs) in people with rheumatoid arthritis. Researchers measured these antibodies in fluid from the gums before and after non-surgical gum treatment. The goal was to better understan…

This study measured the amount and type of dark coloring (pigmentation) on the gums of 70 healthy Egyptian adults. Researchers used standard dental scales to record how widespread and how dark the pigmentation was. The goal was simply to describe normal gum color patterns in this…

This study looked at whether a common jaw joint disorder (anterior disc displacement with reduction) affects pain after root canal treatment. 70 adults with tooth infection and jaw pain were treated and tracked their pain for a week. The goal is to see if dentists should consider…

This study measured levels of three metals—chromium, nickel, and magnesium—in the blood of 74 adults. Some had type 2 diabetes and gum disease, some had only one condition, and some were healthy. The goal was to see if these metals are connected to gum health in people with diabe…

This study looked at 56 extracted teeth to see which polishing method — bristle brush, rubber cup, or air polishing — makes the tooth surface smoothest after scaling. Smoother teeth may help prevent plaque buildup and improve oral health. Researchers used a powerful microscope to…

This study examined how smoking influences immune cells (macrophages) in gum disease. Researchers compared gum tissue from 80 smokers and non-smokers with and without periodontitis. They measured specific markers to see how smoking shifts the balance of immune responses, which ma…

This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and …

This completed study checked the gum health of 226 adults with hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. Researchers measured gum pockets, bleeding, and plaque, and compared them to healthy people. The goal was to see if HS inflammation might …

This study examined whether certain gene variations (FCGR2A and FCGR3A) influence how well the drug cetuximab works in people with advanced upper aerodigestive tract cancers that have spread or come back. Researchers analyzed blood samples from 121 participants to look for these …

This study looked at levels of two immune-related substances, fractalkine and CX3CR1, in the gum fluid of people with gingivitis or periodontitis. Researchers measured these before and after standard non-surgical gum treatment, like deep cleaning and oral hygiene advice. The goal…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study examined 80 postmenopausal women to see if there is a connection between gum (periodontal) disease and osteoporosis. Researchers measured two substances in blood and gum fluid called sclerostin and TNF-α, which may help explain how these conditions affect each other. T…

This study looked at stem cells taken from two different areas of the gums (the front and back of the palate) to see which ones are better at forming bone and other dental tissues. Researchers collected gum tissue from 7 people and grew the cells in the lab to test their ability …

This study looked at whether using a special laser (Nd:YAG) during root canal treatment could help reduce inflammation and oxidative stress in infected teeth. Researchers measured certain markers in fluid samples from 58 patients. The results showed that the laser did not provide…

This study looked at whether smoking and severe gum disease (Stage III periodontitis) increase damage to DNA and RNA in cells. Researchers measured two markers of oxidative stress in saliva from 88 adults, including smokers and non-smokers with and without gum disease. They found…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study tested whether a deep cleaning of the gums (nonsurgical periodontal therapy) could lower inflammation and improve quality of life in 20 people who have both rheumatoid arthritis and gum disease. Researchers measured changes in immune markers, bacteria in the mouth, and…

This study looked at 36 adults who needed gum graft surgery to see how their anxiety before the procedure affected their quality of life and pain during the first month after surgery. Researchers measured anxiety levels and asked patients daily about their oral health and comfort…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study examined how gum disease (periodontitis) and type 2 diabetes affect each other. Researchers measured immune markers, bacteria, and other health signs in 226 adults aged 30-70. The goal was to better understand the connection between these two conditions, not to test a …

This study tested whether treating severe gum disease (periodontitis) with a deep cleaning procedure could also reduce teeth grinding (bruxism) during the day and night. Forty adults with advanced gum disease or healthy gums took part. Researchers measured grinding events before …

This study measured levels of a protein called NLRP6 in the blood of 50 adults with chronic periodontitis (long-term gum disease). Researchers wanted to see if NLRP6 levels are linked to gum health. The study is complete and aimed at understanding the disease better, not testing …

This study looked at three proteins in saliva—IL-6, IL-8, and LIGHT—to see if they can tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers measured these proteins in 60 non-smoking, healthy adults (20 …

This completed study looked at two ways to clean below the gumline in 80 adults with early-stage gum disease. One group received Guided Biofilm Therapy, a newer technique, while the other got conventional cleaning with hand tools and an ultrasonic device. Researchers measured gum…

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This completed study analyzed blood test results from 100 people over age 50 to see if there is a connection between gum inflammation and Alzheimer's disease. Researchers measured gum health and looked at various blood cell counts. The goal was to find blood markers that might li…

This study looked at a new way to fix horizontal jawbone loss by placing a dental implant at the same time as a bone graft. Sixteen patients were treated and followed to see how well the implants and grafts healed. The results showed high implant survival and good bone integratio…

This completed study looked at jawbone X-rays from 120 people—half with gum disease and half healthy. Researchers used special computer analysis to measure bone structure differences. The goal was to see if routine dental X-rays could help detect early bone changes caused by peri…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study looked at certain proteins in the saliva and gum fluid of people with and without gum disease. The goal was to see if these proteins could help explain how gum disease develops. 44 healthy adults took part, and no treatments were given.

This completed study examined 160 children aged 3-14 to see if a Mediterranean-style diet and physical activity habits are linked to better oral health, including less tooth decay and healthier gums. Researchers checked children's teeth and gums and compared them to their eating …

This completed study followed 471 young adults (under 36) with periodontitis for 10 years to see how their gum disease progressed. Researchers looked at factors like disease stage, treatment adherence, and biological markers to understand why some patients got worse or stopped tr…

This study looked at 120 adults with type 2 diabetes and gum disease to see how well their blood sugar was controlled and how it related to the severity of gum problems and cavities. Researchers measured gum health, tooth decay, and HbA1c levels (a measure of blood sugar control)…

This study looked at the free amino acids in saliva from 120 people with healthy gums, gingivitis, periodontitis, healthy implants, implant mucositis, or implantitis. Researchers wanted to see if different amino acid patterns could help tell these conditions apart. The goal is to…

This completed study looked at how low oxygen levels and a metabolic pathway called the kynurenine pathway are involved in gum inflammation (periodontitis). Researchers collected blood and saliva from 45 healthy adults with either periodontitis or healthy gums. They measured mark…

This completed study tested two devices—a special drill (Densah Bur) and a magnetic hammer (Magnetic Mallet)—to see which better prepares a narrow jawbone for dental implants. Only 5 people took part, all with partial tooth loss and enough bone height but not enough width. The ma…

This completed study examined whether people with psoriasis have worse gum health and how it affects their daily lives. Researchers compared 226 adults with and without psoriasis through oral exams and questionnaires. The goal was to understand if the chronic skin condition also …

This completed study looked at whether people with advanced gum disease (periodontitis) also grind or clench their teeth more during sleep. Researchers used a small portable device to measure muscle activity in the jaw over 24 hours in 40 adults, half with severe gum disease and …