Smokers who switch to 'Smokeless' nicotine may see healthier gums, study finds
NCT ID NCT04649645
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in their gum health and tooth appearance. 460 smokers with mild gum disease were randomly assigned to keep smoking, switch to these products, or be never-smokers. Researchers tracked changes in gum inflammation, plaque, and tooth staining over 18 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Combustion-free nicotine delivery systems (e-cigarettes or heated tobacco products)
What this could lead to
If successful, this could show that switching to these products improves gum health and reduces staining compared to continued smoking.
What could go wrong
This is a completed trial, but results may not apply to all smokers. The products still contain nicotine and may have other health risks.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Addendo srl
Catania, Catania, 95100, Italy