Can smoking alter blood vessel proteins in your gums?

NCT ID NCT07765251

Completed Knowledge-focused Sponsor: Inonu University Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study looks at how smoking affects proteins linked to blood vessel formation in gum disease. Researchers will measure levels of KLF2, FBXW7, and other markers in fluid from around the teeth and in saliva from adults who are smokers or non-smokers, with healthy gums, gingivitis, or periodontitis. The goal is to understand the connection between smoking, gum inflammation, and blood vessel health in the mouth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If this research succeeds, it could reveal how smoking worsens gum disease through blood vessel changes, potentially pointing to new ways to prevent or treat gum problems in smokers.
What could go wrong: This is an observational study measuring protein levels, not a treatment trial. It may not prove cause and effect, and results might not apply to everyone with gum disease.

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Conditions

The condition(s) this trial relates to.

gingivitis periodontitis Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GINGIVITIS

Contacts and locations

Locations

Inonu University, Faculty of Dentistry, Deparment of Periodontology

Malatya, 44100, Turkey (Türkiye)

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