Gum surgery upgrade: enamel proteins and bone graft show promise

NCT ID NCT07119307

Completed Disease control Sponsor: Rungta College of Dental Sciences and Research Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This completed study tested a surgical technique called Entire Papilla Preservation (EPPT) alone or with added enamel matrix derivative and bone graft for repairing bone defects from gum disease. Fifty-eight adults with moderate to severe periodontitis took part. The goal was to see if adding these materials improves gum attachment and reduces pocket depth better than surgery alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: enamel matrix derivative and bone mineral derived xenograft
What this could lead to: If successful, this could improve surgical outcomes for repairing bone damage caused by gum disease, potentially saving teeth.
What could go wrong: This is a small, completed Phase 4 trial with 58 participants, so results may not apply to everyone. The procedure is surgical and carries typical risks like infection or gum recession.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRABONY PERIODONTAL DEFECT PERIODONTAL DISEASES

Contacts and locations

Locations

Rungta College of Dental Sciences and Research

Bhilai, Chhattisgarh, 490024, India

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