Can a 'gentle' gum surgery plus enamel proteins rebuild bone? small study hints at yes.
NCT ID NCT07310732
First seen Jan 04, 2026 · Last updated Jun 22, 2026 · Updated 27 times
Summary
This study tested whether adding enamel matrix proteins (Emdogain) and a bovine bone graft to a minimally invasive gum surgery (M-MIST) helps heal deep gum defects better than surgery alone. Forty-five adults with at least one deep gum pocket were treated and followed. The main goal was to see if the combination improved pocket depth and gum attachment levels.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Department of Periodontics, Rungta College of Dental Sciences and Research
Bhilai, Chhattisgarh, 490023, India
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
enamel matrix derivative (Emdogain) and bovine bone mineral xenograft
What this could lead to
If successful, this combination could offer a better way to repair bone and gum damage from periodontal disease, potentially reducing the need for more invasive surgery.
What could go wrong
This is a small, completed study (45 people) without a later-phase follow-up. Results may not apply to everyone, and the added benefit of the extra materials over surgery alone may be modest.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.