Can a 'gentle' gum surgery plus enamel proteins rebuild bone? small study hints at yes.
NCT ID NCT07310732
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding enamel matrix proteins (Emdogain) and a bovine bone graft to a minimally invasive gum surgery (M-MIST) helps heal deep gum defects better than surgery alone. Forty-five adults with at least one deep gum pocket were treated and followed. The main goal was to see if the combination improved pocket depth and gum attachment levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- enamel matrix derivative (Emdogain) and bovine bone mineral xenograft
- What this could lead to
- If successful, this combination could offer a better way to repair bone and gum damage from periodontal disease, potentially reducing the need for more invasive surgery.
- What could go wrong
- This is a small, completed study (45 people) without a later-phase follow-up. Results may not apply to everyone, and the added benefit of the extra materials over surgery alone may be modest.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Periodontics, Rungta College of Dental Sciences and Research
Bhilai, Chhattisgarh, 490023, India
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