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Spit test could spot gum disease early

NCT ID NCT07025291

Diagnosis Sponsor: Izmir Katip Celebi University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is to see if these biomarkers could be used as a simple, non-invasive diagnostic tool for gum disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple saliva test to detect gum disease early, before serious damage occurs.
What could go wrong
This is a small, completed study with only 60 participants. The findings need to be confirmed in larger, more diverse groups before any test becomes available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jul 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy (The identification of healthy volunteers will be based on patients' self-reported medical history; no additional diagnostic tests will be conducted.) * Having at least twenty permanent teeth in the mouth * Non-smoker * Not on any continuous medication * No use of antibiotics, anti-inflammatory drugs, or systemic corticosteroids in the last 6 months * Not pregnant or lactating * No periodontal treatment within the last 6 months * Willing to participate in the study and having signed the "Informed Consent Form" * Between 18 and 65 years of age Exclusion Criteria: * Having any oral or systemic disease * Being on regular systemic medication * Being pregnant or in the lactation period * Having received periodontal treatment within the last 6 months * Having used antibiotics, anti-inflammatory drugs, or systemic corticosteroids in the last 6 months * Smoking * Being under 18 years of age

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Conditions

The condition(s) this trial relates to.

erythrocytosis, familial, 4 gingivitis periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal diseases

Contacts and locations

Locations

  • Izmir Katip Celebi University Faculty of Dentistry

    Izmir, Cigli, 35640, Turkey (Türkiye)

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