Gingival disorder

This study tests whether a less invasive surgery called sentinel lymph node biopsy can replace standard neck dissection for early-stage oral cavity cancer. About 686 patients will be randomly assigned to one of the two procedures. The goal is to see if the gentler approach mainta…

This study looks at whether vitamin D levels and supplements can reduce inflammation in people with gum disease (periodontitis or gingivitis). Researchers will measure markers of inflammation in blood and gum fluid before and after treatment. The study involves 120 adults with di…

This study tests whether microneedling (tiny needle pricks) done before a standard gum surgery can help cover exposed tooth roots in people with thin gums. Thirty-six adults with receding gums will either get microneedling followed by surgery, or surgery with a tissue graft from …

This study compares two surgical techniques to treat gum recession on the lower front teeth. One method uses a flap moved forward plus a graft, while the other uses a different flap design plus a graft. Researchers will measure how much of the exposed tooth root is covered after …

This study is testing whether a special laser device (FX-405) can improve the treatment of gum disease when used along with standard deep cleaning (scaling and root planing). About 70 adults with moderate to severe gum disease will receive eight 10-minute laser sessions over five…

This study tests a new cleaning method (air-polishing with erythritol) against standard cleaning (ultrasound) to prevent white spots on teeth and gum inflammation in 60 teens aged 12-16 who are getting braces. Participants will be followed for 2 years to see which method works be…

This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammatio…

This study looks at two treatments for receding gums. One uses a small piece of tissue from the roof of the mouth (the current standard). The other uses a membrane made from the patient's own blood. The goal is to see which method works better and lasts longer. The study needs 50…

This study tests whether using a smart electric toothbrush with an app and flossing can control gum inflammation as well as getting a professional dental cleaning. 92 adults with mild gum disease will be split into two groups: one uses the smart toothbrush alone, the other gets a…

This study tests a new surgical method called 3D tunneling for treating multiple receding gums, comparing it to a standard technique using a gum graft. Researchers will enroll 36 adults with gum recession to see which approach better covers exposed roots and improves gum health. …

This study tests whether a mouthwash made from black mulberry extract can improve gum health when used along with standard dental cleaning (scaling and root planing). Thirty adults with gingivitis will be split into two groups: one gets cleaning alone, the other adds the mulberry…

This 8-week study tests whether using a compact water flosser (Bixdo A30 Pro) along with regular toothbrushing reduces gum inflammation and plaque better than brushing alone. About 165 adults with plaque-induced gingivitis will be randomly assigned to either use the water flosser…

This study tests a new way to treat multiple receding gums using a substance made from the patient's own blood (Alb-PRF) compared to the standard connective tissue graft. 26 adults with good oral hygiene will be treated and followed to see how much gum coverage is achieved. The g…

This study tests if using an air-polishing device with erythritol powder to clean tooth roots before gum graft surgery works as well as the standard hand-scraping method. Twenty adults with receding gums will be treated and followed for a year. The goal is to see which approach l…

This study compares two ways of doing a gum graft to treat gum recession affecting several teeth. All 32 participants will get a modified tunnel procedure, but half will receive a single continuous graft and the other half a segmented graft. The goal is to see which method better…

This study tests whether a new collagen matrix can work as well as a traditional gum graft for covering exposed tooth roots. Sixty adults who had braces and now have gum recession will receive either the collagen matrix or a graft taken from the roof of their mouth. The goal is t…

This study tests whether adding a daily probiotic tablet and a coenzyme Q10 toothpaste to standard gum cleaning can improve oral health in pregnant women. Forty pregnant women will be split into two groups: one gets the probiotic plus Q10 toothpaste, the other gets only the Q10 t…

This 6-month study tests whether a special antimicrobial mouthrinse can reduce plaque buildup and improve gum health in adults with gingivitis. Participants will brush and rinse twice daily and visit the clinic every 3 months. The goal is to see if the rinse helps control gum inf…

This study tests a surgical technique called free mucogingival graft (FMG) to cover exposed tooth roots and improve gum conditions in the lower front teeth. Researchers will enroll 24 healthy adults with gum recession and unfavorable gum tissue. The goal is to see if this approac…

This study compares a standard gum graft technique with a modified version to treat gum recession on lower front teeth. About 34 healthy, non-smoking adults will receive one of the two procedures. Researchers will use 3D scans to measure tissue thickness and volume changes over 6…

This study compares two surgical techniques (MCAT and VISTA) for treating receding gums in 44 healthy adults. Both methods use a tissue graft to cover exposed roots. Researchers will measure gum thickness changes over 12 months using 3D scans to see which technique works better.

This study tests whether using a toothpaste with sodium bicarbonate (baking soda) and fluoride can help maintain gum health in adults who have already had non-surgical gum treatment. One hundred participants will use either the special toothpaste or a placebo for six months, whil…

This study tests a new toothpaste with stannous fluoride to see if it improves gum health and reduces plaque better than regular fluoride toothpaste. About 300 adults with mild to moderate gum inflammation will brush with the test toothpaste for 24 weeks. Researchers will measure…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…

This study tests whether a daily probiotic lozenge (SALI-10) can prevent gingivitis, a common gum disease that causes bleeding and inflammation. About 60 healthy adults will stop brushing for a short period to allow plaque buildup, then take either the probiotic or a placebo. The…

This study compares two popular mouthwashes, Listerine and Chlorhexidine, to see which better controls gum inflammation and plaque in people undergoing orthodontic treatment with braces. Sixty participants aged 13-40 will use one of the rinses and be checked at 2 and 4 weeks. The…

This study compares two surgical techniques—coronally advanced flap (CAF) and tunneled coronally advanced flap (TCAF)—for covering receding gums in the lower front teeth. Both methods use a small tissue graft from the roof of the mouth to support the gum. Researchers will track 3…

This study compares two surgical techniques—tunneled coronally advanced flap (TCAF) and modified tunnel technique (MTUN)—both using a small piece of tissue from the palate to cover a single receding gum in the lower jaw. Twenty-four adults will be randomly assigned to one procedu…

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study tests whether using a lactoferrin-based toothpaste and mouthwash twice daily, along with regular professional cleanings, can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpas…

This trial compares using tiny titanium tacks versus traditional stitches to hold a gum graft in place after surgery. The goal is to see if the tacks cause less pain and make recovery easier. Adults needing a gum graft around natural teeth will be randomly assigned to one of the …

This study tests whether applying a topical steroid (triamcinolone acetonide) to the roof of the mouth after gum graft surgery can speed healing, reduce pain, and improve quality of life. About 55 adults needing a gum graft will be randomly assigned to receive either the steroid …

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether a special toothpaste can improve gum inflammation (gingivitis) in adults. Sixty participants with moderate gum inflammation will use either the test toothpaste or a regular one for 4 weeks. Dentists will check gum health at the start and end to see if the…

This study tests a gel made from natural particles (polynucleotides) injected into the gums to treat black triangles—gaps between teeth caused by gum loss. About 40 adults with at least one black triangle in the smile zone will receive the gel. The goal is to see if it safely fil…

This study compares a new hydrogel wound dressing called Ora-Aid to a standard plastic stent for reducing pain after gum graft surgery. Twenty adults undergoing the procedure will be randomly assigned to receive one of the two treatments. Researchers will track pain levels, paink…

This study tests three different methods to protect the roof of the mouth after a gum graft. Fifty-six adults will rate their pain, swelling, and bleeding using a simple scale. The goal is to find which protection technique makes healing most comfortable.

This study tests whether using 3D imaging (CBCT) to plan clear aligner treatment can lower the chance of gum recession. Forty adults who want to widen their dental arches will be randomly assigned to either 3D-guided or standard 2D planning. Researchers will track gum health, bon…

This study tests whether a mobile app that sends daily push notifications can help teenagers wearing braces improve their oral hygiene. Braces make it harder to clean teeth, leading to plaque buildup and gum problems. Researchers will compare three groups: app with reminders, app…

This study tests if using a device that reads muscle activity (EMG) to guide Botox injections works better than the standard injection method for people with a gummy smile. About 32 adults with excessive gum display will be split into two groups. The goal is to see which method r…

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than regular round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrushes at home for 4 weeks. Researchers will chec…

This study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests two new solutions, Theravex Oral and Theravex Tissue Care Plus, to see if they help gums heal better after a specific gum surgery for receding lower front teeth. Thirty healthy adults will be randomly assigned to receive either the Theravex treatment or a saltwat…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a gel called Nano Bio Fusion (NBF) to see if it helps heal wounds on the roof of the mouth after gum graft surgery. About 36 adults will apply either the NBF gel or a placebo gel four times a day for four weeks. Researchers will measure wound size, pain, and infl…

This study tests whether a pure green tea mouthwash can reduce dental plaque and gum inflammation better than a placebo or essential oils mouthwashes like Listerine. About 44 healthy adults will rinse with their assigned mouthwash twice daily for 3 weeks, avoiding all other oral …

This study tests whether a hydrogen peroxide mouth rinse called OROXID can help treat gingivitis, a common gum inflammation. About 90 adults with mild gum disease will use the rinse twice daily for 4 weeks, alongside regular brushing. Researchers will measure changes in gum infla…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study compares two surgical techniques—coronally advanced flap (CAF) and tunneled coronally advanced flap (TCAF)—both combined with a soft tissue graft, to treat receding gums in the upper jaw. Thirty-four adults with multiple gum recessions will be randomly assigned to one …

This study tests whether applying ozone therapy (active oxygen) to the gums after gum surgery can help them heal better and reduce pain. 48 adults with gum overgrowth will be randomly assigned to get either standard gum paste or gum paste plus ozone therapy. The researchers will …

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study follows 100 adults with healthy gums or various stages of gum disease over two years. Researchers will collect saliva and plaque samples at yearly visits to measure specific biomarkers. The goal is to see if these markers can predict who will develop or worsen gum dise…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study looks at fluid from the gums of 80 people with gingivitis—half children aged 8-12, half young adults aged 15-24. Researchers will measure inflammation markers to see if they differ by age. The goal is to understand how gum disease develops during growth and puberty.

This study watches 100 adults who are having jaw surgery to fix their bite. Researchers will check gum thickness, gum health, and bone around the teeth before surgery and at 1, 3, and 6 months after. The goal is to see how these tissues change over time. No treatment is given—thi…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study collects dental plaque and checks oral health in 100 adults with high plaque levels. Half have mild gum inflammation, half have moderate-to-severe gingivitis. Researchers will compare the types of bacteria in plaque to understand why some people develop gum disease and…

This study looks at whether children with thin gums are more likely to have severely crowded teeth. Researchers will examine 180 kids aged 5 to 16 at different stages of tooth development. The goal is to find early warning signs so dentists can prevent future gum problems.

This study checks how often two tiny parasites (Entamoeba gingivalis and Trichomonas tenax) are found in the mouths of people with and without gum disease. Researchers will collect spit and plaque samples from 120 adults and look at them under a microscope. The goal is to learn i…

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study looks at how receding gums affect people's quality of life, like eating, smiling, and feeling confident. Researchers will screen 346 adults aged 18-45 to find out how common gum recession is and what causes it. No treatments are tested—just observation and questionnair…

This study watches how gum grafts heal in 15 people after routine surgery for receding gums. Researchers use painless scans and blood flow tests to track swelling and new blood vessel growth. Saliva samples are also checked for healing markers. The goal is to learn what normal he…

This study aims to find biological markers in saliva, gum fluid, and tissue that can predict which people with mild gum inflammation will develop serious periodontitis. Researchers will use advanced techniques to analyze samples from 228 adults aged 18-40 with gingivitis or early…

This observational study at the University of Chile is examining whether a specific immune pathway (JAK1/2) is overactive in people with periodontitis, a common gum disease. Researchers will compare gum tissue from 30 healthy adults and those with inflamed gums to measure pathway…

This study looks at two proteins, Gas6 and sMerTK, in the fluid around teeth to see if they differ between healthy gums, gingivitis, and periodontitis. Researchers will collect samples from 90 adults and measure these proteins. The goal is to better understand the biology of gum …

This study uses a special high-frequency ultrasound to take detailed images of gum tissue. Researchers will compare healthy gums to gums with gingivitis (early gum disease) to see if the ultrasound can detect inflammation. About 40 adults will participate, and the goal is to find…

This study looks at how different oral hygiene routines (including mouthwash) affect gum health, mouth bacteria, and inflammation in people with gingivitis. About 250 adults will use assigned products twice daily for 4 weeks, then stop for 2 weeks to see how their gums and microb…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study looks at how standard gum disease treatments—deep cleaning with or without a special mouthwash—change proteins in your saliva and affect blood vessel health. Researchers will study 30 adults with gum disease to see if these treatments help or harm the good bacteria tha…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study is recruiting 50 adults to understand what factors make gum recession more likely after orthodontic treatment. Researchers will measure gum health, bite patterns, and other dental features in people with and without a history of braces. The goal is to create a simple g…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study is looking at whether certain markers in blood and saliva can predict how well people with gum disease heal after non-surgical treatment. Researchers will measure these markers in 180 adults with healthy gums, gingivitis, or advanced periodontitis before and after trea…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study aims to develop a better way to measure oral health using photographs and imaging software, rather than traditional dental exams. About 275 adults will use different toothpastes or mouthwashes for up to 6 months, and researchers will track plaque levels, gum health, an…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at why people's gums respond differently to the buildup of dental plaque. Researchers will monitor 80 healthy adults aged 18-35 as they stop brushing for a period to allow plaque to grow naturally. The goal is to identify the biological reasons behind varying lev…

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…

This study looks at whether starting to close the gap left by a tooth extraction early (1 week after) or later (8 weeks after) changes the chance of developing a gum cleft. Nineteen orthodontic patients will have one side of their mouth assigned to early closure and the other to …