Gingival disorder

This study tests whether adding hyaluronic acid to a platelet-rich fibrin membrane improves the treatment of receding gums. Thirty adults with a specific type of gum recession will receive either the PRF membrane alone or with hyaluronic acid, alongside a surgical flap procedure.…

This study tests whether a special wipe containing xylitol, a natural sweetener, can reduce dangerous bloodstream infections in children and young adults undergoing stem cell transplants. These infections often start from bacteria in the mouth and can be life-threatening. Partici…

This study compares two types of dental crowns for baby molars in 100 children aged 3-7. Each child gets a zirconia crown on one molar and a stainless steel crown on the opposite molar. Researchers will check gum health, plaque buildup, and parent satisfaction over 3 years to see…

This trial tests whether adding a healing material made from the patient's own blood (Advanced Platelet-Rich Fibrin, or A-PRF) to standard gum surgery helps cover exposed tooth roots better than surgery alone. Eleven adults with gum recession will receive either the combined trea…

This study tests whether a toothpaste with stannous fluoride works better than regular fluoride toothpaste at reducing dental plaque and gum inflammation (gingivitis). About 85 adults with mild to moderate gum disease will brush twice daily for 6 months. Dentists will measure pla…

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…

This study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…

This study aimed to compare two surgical techniques for covering exposed tooth roots caused by gum recession, using a porcine (pig) collagen matrix as a graft material. The trial planned to enroll 20 non-smoking adults with multiple gum recessions. However, the study was withdraw…

This study tested two methods for preparing gum grafts to treat receding gums. One method uses a scalpel outside the mouth, the other uses a radiofrequency device inside the mouth. Forty-eight patients received one of these grafts along with a surgical gum lift. Researchers check…

This study tests a modified pinhole surgical technique for treating localized gum recession. It compares using a bi-layer collagen membrane versus a connective tissue graft to cover exposed tooth roots. The trial involves 18 healthy adults with gum recession and will measure chan…

This study in Malawi tests whether chewing xylitol gum three times a day during pregnancy can improve gum health and change the bacteria in the mouth and vagina. Researchers will also check if it reduces pregnancy complications and affects babies' brain development. 80 pregnant w…

This study compares two different incision methods for gum graft surgery to treat receding gums. Twenty-two adults with gum recession and thin gum tissue will receive a graft made from donated skin. The goal is to see which method covers more exposed tooth root and causes less pa…

This study looks at how the part of a dental crown that sits under the gums is shaped and whether that shape helps keep gums and bone healthy. Thirty people with gum disease who already have a dental implant will get a custom crown. Researchers will measure bone loss, gum thickne…

This study tests whether motivational interviewing, a supportive counseling method, can help teenagers aged 14-19 with braces improve their oral hygiene. Participants receive short, non-judgmental conversations to set their own goals for brushing and flossing. The goal is to redu…

This study looks at whether adding hyaluronic acid (a natural gel) to standard gum graft surgery helps cover exposed tooth roots better and improves healing. Forty adults with receding gums will be randomly assigned to get the graft alone or with the gel. The main goal is to meas…

This study tests whether microneedling, with or without a growth factor injection, can thicken the gum tissue around dental implants. Twenty people with thin gums will receive either the growth factor alone or microneedling plus the growth factor. The goal is to see if this simpl…

This study tests two types of donated human tissue grafts for treating gum recession. Twenty adults who need a gum graft will receive either a standard graft or a new micro-surfaced version. Researchers will compare how well the gum covers the tooth root, how the site heals, and …

This study aimed to compare different surgical techniques for treating receding gums, including a flap procedure and a tunnel approach, with or without a platelet concentrate. It was designed for 100 adults with multiple gum recessions. However, the trial was withdrawn before enr…

This study tested two surgical techniques to fix receding gums on the lower front teeth. 26 adults with gum recession received either a modified laterally stretched technique or a tunneling method with a connective tissue graft. The goal was to see which approach better covers ex…

This study is checking how safe and effective a new membrane made from pig tissue is for dental surgery. It involves 50 adults who need gum tissue regeneration around teeth or implants. Researchers will monitor for complications and measure gum thickness and width over 24 months.

This study tests whether brushing with stannous fluoride toothpaste twice a day for three months reduces gum bleeding and inflammation better than a standard fluoride toothpaste. 120 adults with mild to moderate gingivitis will be randomly assigned to one of three toothpastes. Th…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

This small pilot study tests two different stitching techniques during gum surgery to cover exposed tooth roots caused by gum recession. Seven healthy adults with multiple areas of gum recession will receive both techniques in different parts of their mouth. The goal is to see wh…

This study tests a numbing method called intraseptal anesthesia for gum surgery. Sixty adults with gum disease will receive a small amount of articaine to see if it effectively blocks pain during the procedure. The goal is to find a less painful alternative to standard numbing te…

This study tests whether a mouthwash made from frankincense and coconut oil can help treat mild to moderate gingivitis (gum inflammation). Researchers will compare it to a standard commercial mouthwash in 90 adults over 21 days. The goal is to see if the natural blend reduces pla…

This study tested how well different home oral hygiene devices (like interdental brushes and picks) reduce plaque and gum bleeding in 40 adults with gingivitis. Participants used the tools at home and were checked monthly. The goal was to see which device works best for everyday …

This study looks at whether sonic electric toothbrushes or manual toothbrushes are better at reducing gum inflammation in pregnant women. Gum problems are common during pregnancy due to hormone changes. The trial will follow 120 pregnant women aged 18-40 to see which toothbrush t…

This study tests whether a special nano calcium fluoride varnish, a diode laser, or both together can reduce tooth sensitivity. Thirty adults with sensitive teeth will receive one of the treatments and rate their pain on a scale. The goal is to see which approach provides the bes…

This study looks at whether applying a hyaluronic acid gel (Gingigel) and using a special light therapy (photobiomodulation) can help gums heal better and with less pain after a common gum surgery called gingivectomy. About 38 adults with enlarged gums will be split into three gr…

This study looks at two different ways clear aligners are trimmed—one that sits on the gums and one that stops at the gum line—to see which leads to less plaque and healthier gums. Twenty adults with mild to moderate crowding will wear both designs at the same time (one on top, o…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and infl…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study looks at how metal and ceramic braces change the bacteria in dental plaque (biofilm) and affect gum health in 80 people with crooked teeth. Researchers will measure the types and amounts of bacteria, plaque buildup, and gum swelling. The goal is to understand how diffe…

This study tests four different methods for removing the surface layer of gum tissue during dental grafting surgery. The methods include a surgical blade, a special drill (mucotome), a diamond bur, and a laser. Researchers will measure how much tissue remains, how long the proced…

This early-phase study tests whether strawberry gummies can improve oral health in 36 adults, including smokers and non-smokers. Participants eat two types of gummies (real strawberry or placebo) four times daily for a week. Researchers measure how the body absorbs strawberry com…