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Could chewing gum during pregnancy protect Babies' brains?

NCT ID NCT06329596

Ongoing Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study in Malawi tests whether chewing xylitol gum three times a day during pregnancy can improve gum health and change the bacteria in the mouth and vagina. Researchers will also check if it reduces pregnancy complications and affects babies' brain development. 80 pregnant women are participating, with half chewing xylitol gum and half chewing a similar gum without xylitol.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Xylitol gum
What this could lead to
If it works, this could point toward a simple, low-cost way to improve gum health and reduce pregnancy complications in regions with limited dental care.
What could go wrong
This is an early-phase study with only 80 participants, so results may not apply broadly. Chewing gum may not be enough to significantly change the microbiome or prevent complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Dysbiosis gingivitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DYSBIOSIS INFLAMMATION GUM MICROBIOATA NEURODEVELOPMENTAL CHANGES (CHILDHOOD, AGEING) PLACENTA-MEDIATED PREGNANCY COMPLICATIONS

Contacts and locations

Locations

  • Area 25 Health Center

    Lilongwe, Malawi

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