Baylor College Of Medicine

This early-stage trial is testing a new type of cell therapy for aggressive brain tumors that have returned or stopped responding to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to better recognize and attack cancer ce…

This study is testing a new cell therapy for children with neuroblastoma that has come back or hasn't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better find and attack cancer cells, and then infuse them back into the patient …

This early-stage study tests a new type of cell therapy for lymphoma linked to Epstein-Barr virus (EBV). Researchers take a patient's own immune cells, modify them with a gene called C7R to help them survive longer, and infuse them back to attack the cancer. The main goals are to…

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This early-stage study is testing a new version of a cancer treatment called CAR-T cell therapy for people whose lymphomas have returned or not responded to standard treatments. Researchers are using pre-made immune cells from healthy donors, modified to better target a protein (…

This study is testing whether some patients with chronic myeloid leukemia (CML) who have been in a stable, deep remission for years can safely stop their daily medication. Researchers want to see if these patients can remain cancer-free without treatment, which would spare them f…

This study is testing whether a new tool, called a traction device, can help doctors remove large or difficult-to-reach colon polyps more effectively. The device is designed to gently pull on tissue during a special endoscopic procedure, potentially making the process quicker and…

This study is collecting information on how well a new surgical tool works for a procedure to treat a rare swallowing disorder called achalasia. It will follow 40 patients who are already scheduled to have the standard surgery. The goal is to see if the new tool is safe and effec…

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific marker called GPC3. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then inf…

This study is testing if giving a higher, weekly dose of a protein called albumin can better control a dangerous fluid buildup in the abdomen (ascites) for people with advanced liver cirrhosis. It will compare the standard care to standard care plus weekly albumin infusions in 10…

This early-stage study is testing a new treatment for multiple myeloma and related conditions. Doctors take a patient's own immune cells, train them in a lab to recognize and attack cancer cells, and then infuse them back into the patient. The main goals are to find the safest do…

This early-stage study is testing a new type of cell therapy for adults with a recurrent, aggressive brain cancer called glioblastoma. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack cancer cells, and then inject them …

This early-stage study is testing a new cell therapy for adults and children with T-cell leukemia or lymphoma that has come back after a stem cell transplant. Doctors take a patient's or their donor's immune cells, modify them in a lab to better target the cancer, and infuse them…

This study aims to test and validate a standard care plan for managing unborn babies diagnosed with a lower urinary tract obstruction (LUTO), a serious blockage in the bladder. It will enroll 50 pregnant women to follow this detailed plan, which includes specialized monitoring, p…

This large study is testing whether a newer pacemaker technique (His or Left Bundle Branch Pacing) works better than the standard method (Biventricular Pacing) for people with heart failure and a weak heart pump. It will enroll over 2,100 adults to see which method is more effect…

This study is testing a new way to treat certain lymphomas linked to the Epstein-Barr virus (EBV). Doctors take a patient's own white blood cells, train them in a lab to recognize and attack EBV-infected cancer cells, and then infuse them back into the patient. The main goals are…

This study is testing a new way to coordinate care for cancer patients who also have other ongoing health problems like diabetes or high blood pressure. It will involve 340 patients with breast, gastrointestinal, or blood cancers. The goal is to see if better teamwork between can…

This early-phase study is testing a new type of treatment called CAR-T cell therapy for adults with advanced B-cell blood cancers that have returned or not responded to standard treatments. Doctors take a patient's own immune cells, genetically modify them in a lab to better reco…

This early-stage study is testing the safety of a two-part treatment for advanced sarcomas that have stopped responding to standard therapies. Doctors take a patient's own immune cells, genetically modify them to recognize and attack cancer cells, and then infuse them back. These…

This study compares two different surgical entry techniques used during laser surgery for twin-to-twin transfusion syndrome, a serious pregnancy complication. Researchers want to see which method causes fewer problems with the membranes separating after surgery. The study involve…

This study is testing a new type of stent graft device to repair dangerous bulges (aneurysms) in the body's main artery, the aorta. The device is inserted through a small incision in the groin and has special holes or branches to keep blood flowing to vital organs. Researchers ar…

This study is testing if a single chemotherapy drug (cytarabine) works as well or better than the current standard two-drug combination (vinblastine/prednisone) for treating Langerhans cell histiocytosis (LCH), a rare cancer. It will enroll 124 children and young adults up to age…

This early-phase study is testing a new cell therapy for adults and children with aggressive T-cell leukemias or lymphomas that have returned or not responded to standard treatments. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize a…

This study is testing whether guided psilocybin sessions combined with therapy can safely and effectively treat PTSD in US military veterans. Fifteen veterans will receive two psilocybin sessions alongside psychotherapy. Researchers will measure changes in PTSD symptoms, depressi…

This study is testing two different drug combinations given before surgery for pleural mesothelioma, a cancer often linked to asbestos exposure. The goal is to see if these treatments can better control the cancer and keep it from coming back after surgery. Researchers will compa…

This study is for people who need a stem cell transplant but don't have a perfectly matched donor. Researchers are testing a way to prepare stem cells from a 'half-matched' family donor to lower the risk of a dangerous complication where donor cells attack the patient's body. The…

This study is testing a new surgery performed on babies while they are still in the womb to repair a serious birth defect called complex gastroschisis, where the intestines develop outside the body. The goal is to see if this early repair is safe and possible, and if it helps bab…

This early-phase study is testing a new, experimental cell therapy called TRICAR-ALL for children and young adults (ages 1-25) whose B-cell acute lymphoblastic leukemia (ALL) has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells (T ce…

This study aims to provide faster genetic diagnoses for seriously ill newborns in Texas hospitals, especially those with fewer resources. Researchers will offer rapid genetic testing and virtual doctor consultations to 200 infants over five years. The goal is to see if this appro…

This study is testing a new AI-powered camera device that attaches to a standard endoscope. The goal is to see if it helps doctors more accurately identify pre-cancerous and cancerous spots in the esophagus during routine screening, potentially reducing the number of unnecessary …

This study is testing whether a short, animated video and flyer can help patients provide cleaner urine samples. Better samples lead to more accurate test results, which could prevent incorrect UTI diagnoses and reduce unnecessary antibiotic prescriptions. Researchers will compar…

This study is testing a program that combines food prescriptions with feeding education for parents to help prevent childhood obesity. Researchers want to see if this approach is practical and acceptable for families. The program teaches parents healthy feeding practices while pr…

This study is testing a 30-day program using a smartphone app and a smart scale to help Hispanic teenagers improve their health. The app tracks weight, activity, sleep, and diet, and sends daily tips to encourage healthier habits. The goal is to see if this digital tool is easy t…

This small pilot study is testing whether combining two painless, non-invasive brain stimulation techniques can help manage difficult behavioral and emotional symptoms in people with Alzheimer's disease. The study aims to see if the treatment process is practical for patients and…

This study is testing whether intensive, condensed versions of cognitive-behavioral therapy (CBT) can help veterans and service members with PTSD and anxiety disorders. Researchers are comparing two different delivery methods—individual sessions over two weeks versus group sessio…

This study is testing whether wearing special light glasses for 30 minutes each weekday can help reduce fatigue and improve attention and thinking skills in children and teens who have survived a brain tumor. It's a small pilot study with 40 participants to see if this approach i…

This study is testing if a gentle, non-invasive electrical stimulation delivered to the ear can improve attention and memory in veterans with traumatic brain injuries (TBI). Thirty participants will try both a real and a fake (placebo) stimulation session to see if the real treat…

This study aims to understand how brain activity relates to mood, particularly in depression. Researchers will record brain signals directly from 58 participants who are already undergoing monitoring for epilepsy or treatment for severe depression. Using advanced computer analysi…

This study aims to help develop a future hookworm vaccine by first creating a safe, controlled infection model. Healthy adult volunteers who have never had hookworm will have a small number of larvae applied to their skin to see how their bodies react. Researchers will monitor sa…

This study aims to measure precisely how a sedative drug called dexmedetomidine affects the amount of inhaled anesthesia (sevoflurane) needed to keep children asleep during surgery. Researchers will enroll 180 children between 1 month and 3 years old to test two different doses. …

This study aims to understand TANGO2-related disorder, a rare genetic condition that can cause severe muscle breakdown and dangerous heart rhythms. Researchers will collect medical information and tissue samples from 300 people with the condition to track how the disease progress…

This study aims to understand how the body processes a nutrient called arginine in teenagers with type 2 diabetes. Researchers will test if giving extra arginine can help the pancreas produce more insulin. The goal is to gather knowledge that could lead to new, low-cost ways to m…

This study aims to understand how nutrients called carotenoids, found in colorful fruits and vegetables, relate to vision development in infants and toddlers. Researchers will follow 208 healthy children, checking their diet, taking a small blood sample, measuring carotenoid leve…

This study aims to understand if genetic conditions are a hidden cause of a serious newborn brain injury called HIE, which happens when a baby's brain doesn't get enough oxygen. Researchers will offer detailed genetic testing (genome sequencing) to 25 newborns with HIE who are re…

This study aims to understand how supporting mothers of hospitalized infants affects family wellbeing. Researchers will connect mothers experiencing depression, anxiety, or food insecurity with helpful resources and emotional support. They want to see if this assistance improves …

This study aims to understand how the brain processes social and emotional information in people with severe, treatment-resistant depression or epilepsy. Researchers will record brain activity using electrodes placed inside the skull for clinical monitoring. The goal is to map th…

This study aims to find better ways to detect, prevent, and treat tuberculosis (TB) in people living with HIV. It will test new screening tools, compare different preventive treatment delivery methods, and analyze costs to improve care for 6,500 participants. The goal is to gener…