Baylor College Of Medicine

This early-phase study tests a new therapy using a patient's own immune cells (T cells) trained to attack proteins found on myeloma cells. It includes people with active multiple myeloma or high-risk precursor conditions (MGUS or smoldering myeloma). The main goals are to find a …

This early-stage study tests a new type of cell therapy for people with certain lymphomas that have come back or not responded to treatment. The therapy uses immune cells from healthy donors that are modified to better recognize and attack cancer cells, plus an added molecule to …

This early-phase trial tests a new cell therapy for people with T-cell leukemia or lymphoma that has come back or not responded to treatment. Researchers take a patient's own T-cells, add a special receptor (CD7.CAR) to help them recognize and attack cancer cells, and give them b…

This early-phase study tests a new gene therapy for people with aggressive brain tumors that have a protein called GD2. Researchers take a patient's own T cells, add a special receptor to help them recognize and attack GD2 on cancer cells, plus a gene that helps the T cells live …

This study tests a new treatment for children with neuroblastoma that has come back or not responded to standard therapy. Doctors take the child's own immune cells (called NKT cells), add a special receptor to help them find and kill cancer cells, and give them back along with a …

This study tests a new way to make special immune cells (T cells) that can attack cancer cells infected with the Epstein-Barr virus (EBV). The cells are grown faster in the lab and given to patients with Hodgkin or non-Hodgkin lymphoma, or related diseases that have come back or …

This study tests whether a combination of two immunotherapy drugs (durvalumab and tremelimumab) works better with or without chemotherapy for people with pleural mesothelioma that can be surgically removed. The goal is to see if these treatments can keep the cancer from returning…

This early-phase study tests a new type of immunotherapy for people with advanced B-cell lymphoma or leukemia that has returned or not responded to standard treatment. Researchers take a patient's own T-cells (a type of immune cell), add a special receptor that targets a protein …

This early-phase study tests whether giving specially engineered immune cells (HER2-CAR T cells) together with an immune checkpoint inhibitor (pembrolizumab or nivolumab) is safe and can help people with advanced sarcoma. About 25 participants will receive chemotherapy to prepare…

This study looks at how safe and effective custom-made stents are for treating complex bulges or tears in the main artery (aorta). About 760 people with large or fast-growing aneurysms will receive these special stents. Researchers will track deaths, major complications like hear…

This early-phase study tests a new type of immunotherapy for adults with solid tumors that have a specific marker called GPC3. The treatment involves taking a patient's own T cells, adding genes to help them recognize and attack cancer cells, and then giving them back. The study …

This study tests whether giving a higher dose of albumin (a protein) to people with advanced liver cirrhosis and severe fluid buildup (ascites) can reduce the need for frequent fluid drainage procedures. About 100 adults with hard-to-treat ascites will receive either standard or …

This study tests a standard care plan for unborn babies diagnosed with lower urinary tract obstruction (LUTO), a condition where urine flow is blocked. Researchers will follow 50 pregnant women and their babies to see if this approach improves survival and kidney function up to 2…

This study is for people who need a stem cell transplant but don't have a perfectly matched donor. Instead, they can use a half-matched relative's stem cells. To lower the risk of a serious complication called graft-versus-host disease (where donor cells attack the patient), the …

This study looks at whether a special treatment plan for children with acute myeloid leukemia (AML) can work well in Malawi, where resources are limited. About 30 children under 18 will receive a treatment guideline designed to balance curing the disease with manageable side effe…

This study tests a program for youth aged 10 to 13 with type 1 diabetes and their parents. The program helps families identify and build on the child's diabetes strengths to improve blood sugar control, daily management, and quality of life. About 250 participants will take part …

This early-phase trial tests a new experimental treatment called CARE T cells for children and young adults with certain solid tumors (like liver cancer or Wilms tumor) that have returned or not responded to standard therapy. The treatment involves taking a patient's own immune c…

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,100 adults with heart failure and a weak heart pump. The goal is to see if the newer method improves quality of life, reduces hospital stay…

This study tests a new treatment for people with EBV-positive Hodgkin or non-Hodgkin lymphoma that has returned or not gone away. The treatment uses the patient's own T-cells that are genetically modified to produce a protein called C7R, which helps them survive longer in the bod…

This study tests whether repairing a severe birth defect called complex gastroschisis while the baby is still in the womb is safe and possible. Ten pregnant women will undergo a minimally invasive fetal surgery to put the baby's intestines back inside and close the opening. The g…

This study tests whether a single chemotherapy drug, cytarabine, works better than the usual two-drug combination (vinblastine/prednisone) for treating Langerhans cell histiocytosis (LCH), a rare cancer that causes tissue damage. About 124 children and young adults up to age 21 w…

This early-phase study tests a new treatment for people with T-cell leukemia or lymphoma that has come back. The therapy uses the patient's own (or their donor's) immune cells, which are modified in the lab to better recognize and attack cancer cells. The goal is to see if this a…

This early-phase trial tests a new treatment for recurrent glioblastoma, a fast-growing brain cancer. Researchers take a patient's own immune T cells, add a gene to help them recognize and attack tumor cells, plus a growth factor to keep them active longer. The modified cells are…

This study tests a new way to care for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It brings together cancer doctors and primary care providers to improve communication and support. The goal is to help patients better manage their …

This study tests a new treatment for children and young adults (ages 1-25) with B-cell acute lymphoblastic leukemia (ALL) that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells (T cells) that are modified in the lab to recognize…

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors, such as breast, lung, or gastric cancer. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A few days…

This study is testing a new, portable microscope that uses artificial intelligence to help doctors spot early signs of esophageal cancer. About 200 adults in Brazil and the United States who are already scheduled for a routine screening procedure will also be examined with this d…

This small pilot study tests whether a steroid cream applied to the penis can prevent repeat urinary tract infections (UTIs) in uncircumcised male infants under 6 months old who have already had one UTI. Half the babies get the steroid cream, half get a placebo cream, applied twi…

This study tests whether giving parents food prescriptions along with advice on healthy feeding can help prevent chronic diseases like obesity in children. About 375 parents of 4-8 year olds in Texas will try the program for 3 months. Researchers will check if the approach is pra…

This study tests a mobile health app designed to help Hispanic adolescents (ages 12-18) who are overweight and at high risk for type 2 diabetes. The app monitors physical activity, sleep, and diet, and provides feedback to encourage healthier habits. The goal is to see if the app…

This study tests a new type of knife that uses bipolar radiofrequency energy to remove precancerous growths from the esophagus. The goal is to see if this tool is safe, effective, and faster than current methods. About 50 adults with certain precancerous lesions in the upper esop…

This pilot study tests a non-invasive ear stimulation method (taVNS) to see if it can improve attention and memory in veterans with traumatic brain injury (TBI), depression, or PTSD. Thirty veterans will each receive both active and sham stimulation in one visit while performing …

This pilot study tests a combination of two non-invasive brain stimulation methods—iTBS and tDCS—in 20 older veterans with mild to moderate Alzheimer's disease who also have mood or behavior symptoms like agitation or apathy. Participants will receive one week of in-clinic iTBS s…

This study compares two intensive formats of cognitive behavioral therapy for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which format best reduc…

This study tests whether daily bright light exposure can reduce fatigue and improve thinking in children and teens who have survived a brain tumor. About 40 participants will use a special light box at home for 6 weeks. The goal is to see if this approach is practical and liked b…

This study compares two ways to remove abnormal growths from the colon: using a special traction device versus the standard method. The goal is to see if the device helps doctors complete the procedure faster and with fewer complications. About 150 adults with certain types of co…

This study looks at how safe and effective a new tool, the Speedboat UltraSlim™, is for a procedure called POEM that helps people with achalasia (a condition where the throat muscles don't relax properly). About 40 adults will be watched for up to a year to see if their swallowin…

This study enrolls 120 women with ovarian cancer who have finished their initial treatment. It tests a special survivorship care program (POSTCare-O) designed to provide support during the transition after treatment. Participants are randomly assigned to receive the program or us…

This study tests a new device called Pathfinder that helps doctors remove colon tumors more easily. The device stiffens the scope to give better control, which may shorten surgery time and reduce complications. About 66 adults with certain colon growths will be randomly assigned …

This study tests whether a guided therapy session using psilocybin (the active ingredient in magic mushrooms) can help US Veterans with PTSD. Fifteen participants will receive two psilocybin sessions along with talk therapy. The goal is to see if this approach is safe and reduces…

This study aims to learn how genetic changes contribute to microphthalmia, anophthalmia, and coloboma (MAC) in children. Researchers will collect medical histories, conduct physical exams, and analyze DNA from saliva or blood samples. Up to 3,000 children and their family members…

This study looks at how the body processes arginine, a natural nutrient, in teenagers and young adults with type 2 diabetes. Researchers will compare 30 youth with diabetes to healthy controls using safe, minimally invasive tests. The goal is to understand the disease better and …

This study collects health information and biological samples from 300 people with TANGO2 deficiency, a rare genetic condition. Researchers will track hospitalizations and other health events to better understand how the disease progresses. The goal is to build a database and sam…

This study looks at how two different doses of dexmedetomidine, a sedative, affect the amount of sevoflurane (an inhaled anesthetic) needed to prevent movement during surgery in children aged 1 month to 3 years. Researchers will enroll 180 children and check their response to a s…

This study looks for better ways to find and prevent tuberculosis (TB) in people living with HIV, especially children and teens. Researchers will test a new screening method and a blood test to improve TB detection. They will also compare different support methods to help patient…

This study compares two surgical entry techniques for fetoscopic laser surgery in twin-to-twin transfusion syndrome. Researchers want to see if one method causes less separation of the membrane around the baby. The study will enroll 216 pregnant women between 16 and 26 weeks of p…

This study tests whether a short animated video and a picture guide can help patients collect cleaner urine samples. Contaminated samples often lead to wrong UTI diagnoses and unnecessary antibiotics, which fuels drug resistance. About 252 adults in primary care will either watch…

This study aims to find the specific gene change that causes Aicardi syndrome, a rare brain disorder. Researchers will collect blood and skin samples from up to 500 people with the condition and their parents. They will use advanced DNA sequencing to look for genetic differences …

This study provides advanced genetic testing and virtual doctor consultations for seriously ill newborns in Texas hospitals with fewer resources, especially near the Texas-Mexico border. Researchers will test a virtual consultation tool called Consultagene and gather feedback fro…

This study aims to better understand how the brain controls mood by recording brain activity directly in people with depression or epilepsy. Researchers will use artificial intelligence to analyze these recordings and link them to mood changes. The goal is to improve treatments f…

This study uses special brain recordings (intracranial electrodes) to map how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers aim to understand the brain networks involved in these feelings, which could l…

This study offers genome sequencing to 25 newborns diagnosed with hypoxic-ischemic encephalopathy (HIE) who are receiving cooling therapy. Researchers want to find out how often genetic conditions contribute to HIE. The goal is to better understand which babies might benefit from…

This study aims to help families facing food insecurity and mothers with depression by providing resources like food, rent assistance, and mental health support. Researchers will enroll 2,000 caregivers of young children hospitalized at Texas Children's Hospital to see if these i…

This study tests a new wireless, bandage-like sensor called FlowSense that measures fluid flow in shunts used to treat hydrocephalus. Researchers will compare its readings with standard drainage and pressure measurements in 24 patients who already have external ventricular drains…

This study aims to find the safest dose of hookworm larvae that causes a consistent infection in healthy adults. Researchers will use this model to later test a vaccine against hookworm. About 35 volunteers aged 18-45 will receive larvae through the skin and be monitored for side…

This study looks at how the healthy pigments (carotenoids) from fruits, vegetables, and formula show up in babies' skin and blood, and whether they help with vision development. Researchers will follow 208 healthy infants and toddlers from 4 to 24 months old, measuring their diet…