Baylor College Of Medicine

This study tested a new vaccine to prevent hookworm infection in 39 healthy adults who had never had hookworms before. Participants received different versions of the vaccine and were then exposed to hookworms in a controlled setting to see if the vaccine could prevent infection.…

This study tested a new vaccine (Sm-TSP-2) to protect against intestinal schistosomiasis, a parasitic worm infection common in parts of Africa. Healthy adults in Uganda received different doses of the vaccine, with or without an immune booster, to check safety and how well it tri…

This study tests a new, minimally invasive surgical technique to repair open neural tube defects (spina bifida) in unborn babies. Instead of opening the uterus, surgeons use a tiny camera and tools inserted through small incisions. The goal is to close the spinal defect effective…

This pilot study tested whether adding the anti-inflammatory drug celecoxib (Celebrex) to standard chemotherapy before bladder cancer surgery is safe and affects tumor genes. 22 people with muscle-invasive bladder cancer took part. The goal was to see how the treatment changed ca…

This study tested whether giving Hispanic teenagers a Fitbit and sending them text messages could help them be more active and sleep better. The goal was to reduce their risk of type 2 diabetes. 43 teens aged 14-16 with obesity took part. The study measured how many teens joined,…

This study tested a new experimental treatment called HPVST cells in 32 people with HPV-related cancers that had returned or not responded to standard care. The cells are grown from the patient's own blood and trained to attack HPV-infected cancer cells. The goal was to find a sa…

This study tested whether adding the sleep medication lemborexant (Dayvigo) to the standard alcohol craving drug naltrexone helps people with alcohol use disorder and insomnia. Eight adults took either the combination or naltrexone plus a placebo. Researchers measured alcohol cra…

This early-phase study tested a new type of cell therapy for people with advanced B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia (CLL) that had returned or not responded to standard treatments. Researchers took patients' own immune cells (T-cells) and added a special…

This study tested whether adding human milk cream to breast milk or donor milk could help very low birth weight preterm infants get enough calories. Many preterm babies receive milk that has fewer calories than expected, which can slow their growth. Researchers measured the calor…

This study looked at whether giving very low birth weight premature infants (under 1000 grams) a high-protein diet helps them grow longer and build more lean muscle compared to a standard protein diet. The researchers used an exclusive human milk diet with added protein fortifier…

This study tested whether adding a cream made from human milk to the standard feeding of extremely premature babies (birth weight 500-1250 grams) could help them leave the hospital earlier. 210 infants were randomly assigned to get either the cream supplement or standard care. Th…

This study tested a new treatment for children with high-risk neuroblastoma, a type of cancer. Researchers took the patients' own immune cells (T cells) and modified them to recognize and attack the cancer. Some of these cells were also trained to fight a common virus (EBV) to he…

This study tested whether trained peer mentors (ages 20-35) could help young adults (ages 17-25) with type 1 diabetes better control their blood sugar and smoothly move from pediatric to adult diabetes care. 144 participants were randomly assigned to receive peer support or usual…

This study tested a new experimental therapy using special immune cells (T cells) trained to attack proteins found on pancreatic cancer cells. The trial included 37 patients whose cancer had returned or not responded to standard treatment, or who chose not to have chemotherapy. T…

This early-phase trial tested a chemotherapy regimen called DA-EPOCH-R in 4 children with certain B-cell cancers (DLBCL, PMBCL, or PTLD). The drugs are given as a continuous infusion over several days, and doses are adjusted based on how the child's body handles them. The goal wa…

This study tested a program called THRIVE for hospitalized people with HIV who were not regularly seeing a doctor. The program uses acceptance and commitment therapy to help patients overcome avoidance and stigma. Researchers enrolled 75 participants to see if the program was acc…

This study tested whether adding acupuncture to standard anti-nausea drugs could better prevent nausea and vomiting after laparoscopic gallbladder removal. 270 adults scheduled for surgery received either acupuncture plus standard drugs or standard drugs alone. The goal was to se…

This study tested whether mailing HPV self-test kits to women who are overdue for cervical cancer screening could increase participation. Over 2,400 underserved women in Texas were randomly assigned to receive a kit or standard phone reminders. The goal was to see if the at-home …

This study compared two different surgical knives used during a procedure called POEM, which treats swallowing disorders by cutting throat muscles. 104 adults were randomly assigned to receive either a standard monopolar knife or a newer bipolar knife (Speedboat-RS2). The goal wa…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This pilot study tested whether a guided imagery therapy mobile app could help children aged 7 to 12 with chronic abdominal pain. Four children listened to 10-15 minute recorded sessions five days a week for eight weeks. The study compared immediate app use to a delayed start gro…

This study investigates whether a non-invasive brain monitoring tool can predict brain injury in extremely low birth weight infants (≤1000 grams) during their first week of life. Researchers will measure brain blood flow using ultrasound and other sensors to see if changes in per…

This early-phase trial tested whether adding atovaquone (a drug usually used to prevent pneumonia) to standard chemotherapy is safe and reaches effective levels in the blood. It involved 26 children and young adults (ages 1 month to 21 years) newly diagnosed with acute myeloid le…

This study looked at how using a tablet in the evening affects young children's sleep and thinking skills. Researchers compared kids who used a tablet before bed with those who had no screen time. They measured changes in sleep timing, melatonin levels, and executive function. Th…

This study tested a newer biopsy method called fine-needle biopsy (FNB) for diagnosing pancreatic masses. Researchers wanted to see if FNB could provide better tissue samples than the standard fine-needle aspiration (FNA) without needing a cytologist on site. Fifty-two adults wit…

This study looked at 163 children aged 7-12 with chronic abdominal pain to see if simple tests (biomarkers) could predict whether they would benefit more from cognitive behavioral therapy (CBT) or a low FODMAP diet. The goal was to personalize treatment and improve symptoms and q…

This study looked at whether adding extra vitamin D to formula for preterm babies (born 28-34 weeks) helps maintain healthy vitamin D levels and supports bone development. 39 infants received either standard or higher vitamin D formula until about 52 weeks adjusted age. The main …

This study looked at how very low birth weight babies (under 1250 grams) are fed donor human milk in the NICU at Texas Children's Hospital. The goal was to see if current feeding practices follow hospital guidelines, especially for monitoring electrolyte levels. Researchers wante…

This study looked at how often children's oxygen levels drop after surgery for sleep apnea. 178 children who had their tonsils and adenoids removed were monitored with a continuous pulse oximeter. The goal was to better understand oxygen desaturation patterns in the hospital afte…