Baylor College Of Medicine

This early-phase study tests a new treatment for people with relapsed lymphoma tied to the Epstein-Barr virus. The therapy uses the patient's own immune cells, modified to resist a substance tumors use to hide. The goal is to find a safe dose and see if these cells can shrink tum…

This study tests a new treatment called AGAR T cells for children whose solid tumors (like liver cancer or Wilms tumor) have returned or not responded to standard care. The treatment involves taking a patient's own immune cells, adding genes to help them recognize and attack tumo…

This study tests a video-based program called VITAL Start for Adolescents to help teens living with HIV take their medication regularly and stay healthy. About 1,800 teens and their caregivers in Malawi will either watch the videos plus get standard care, or just get standard car…

This early-phase study tests a new approach for people with CD19-positive blood cancers (like lymphoma or leukemia) that returned after a stem cell transplant. Researchers take immune cells (T cells) from the original stem cell donor, modify them to better recognize and attack ca…

This study tests a new treatment for people with advanced sarcoma, a type of cancer that has not responded to standard therapies. Researchers take a patient's own immune cells (T cells) and add a new gene to help them recognize and attack cancer cells that have a protein called H…

This study looks at whether a weight loss program called "Paso a Paso" is practical for Mexican and Central American adults with fatty liver disease and overweight. Researchers will track attendance, weight loss, liver health, and diet changes in 50 participants. The goal is to s…

This study tests whether a non-invasive headband device, originally approved for migraines, can help reduce seizures in veterans with drug-resistant epilepsy. 24 veterans will receive either standard care alone or standard care plus the device, then switch groups. The goal is to …

This early-phase study tests a new therapy using specially trained immune cells from a donor to target and kill cancer cells in people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) whose disease has returned or not gone away after a stem cell transplant. The…

This early-stage study tests a new treatment for adults with acute myeloid leukemia (AML) that has returned or not responded to standard therapy. The treatment uses the patient's own immune cells, called T cells, which are modified in a lab to recognize and attack AML cells carry…

This early-phase study tested a new treatment for people with B-cell lymphoma or leukemia that returned after standard therapy. Researchers took patients' own immune cells (T cells), added a special receptor to help them recognize and attack cancer cells, and infused them back. T…

This study looks at whether a protein supplement called carnitine can help reduce hardening of the arteries in teenagers at high risk for future heart disease. About 90 teens aged 11-21 with high triglycerides will take carnitine or a placebo. The goal is to see if carnitine can …

This study tests a new treatment for people with certain blood cancers (lymphoma, multiple myeloma, or CLL) that have returned or not responded to standard therapy. Researchers take a patient's own immune cells (T cells) and modify them in the lab to better recognize and attack c…

This early-stage study tests a new kind of cell therapy for children whose neuroblastoma has come back or not responded to standard treatment. Researchers take the child's own immune T cells, add genes to help them recognize and attack neuroblastoma cells, and also include a safe…

This study was designed to see if adding a drug called 5-azacytidine (AZA) to standard steroid treatment could help protect the gut in people with graft-versus-host disease (GVHD) after a stem cell transplant. GVHD occurs when donor cells attack the patient's body, and gut involv…

This study compares two minimally invasive fetal surgery techniques to repair neural tube defects (like spina bifida) before birth. One group of babies receives a repair using a special patch (Durepair), while a previous group had the repair without the patch. The goal is to see …

This study is testing whether some patients with a type of leukemia called CML, who have been in a very deep remission for years while taking daily TKI pills, can safely stop taking those pills and stay in remission. Researchers will monitor 100 patients closely after they stop t…

This early-stage trial tests a new treatment called CATCH T cells for people with certain solid tumors that have come back or not responded to standard care. The treatment involves taking a patient's own immune cells, adding new genes to help them recognize and attack cancer cell…

This early-phase study tests a new treatment for people with HER2-positive brain tumors that have come back or not responded to standard care. The treatment involves taking a patient's own immune cells (T cells), adding a special antibody (HER2-CAR) to help them recognize and att…

This study tests a new way to do stem cell transplants using cells from a half-matched family donor. By removing certain immune cells before transplant, researchers hope to lower the risk of graft-versus-host disease, a serious complication. The goal is to help patients with bloo…

This study tests whether specially trained immune cells from healthy donors can safely fight cancers and diseases caused by the Epstein-Barr virus (EBV). Participants have EBV-positive lymphoma, nasopharyngeal carcinoma, or other EBV-related conditions that returned or didn't res…

This early-stage trial tests a new treatment for children and young adults with a type of liver cancer that has returned or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells that carry a pr…

This early-stage study tests a new treatment for advanced osteosarcoma and neuroblastoma that has not responded to standard therapies. Researchers take a patient's own immune cells, add a special receptor to help them recognize and attack cancer cells, and combine them with a chi…

This early-phase study tests a new immune cell therapy for people with a type of throat cancer linked to the Epstein-Barr virus. The treatment uses the patient's own T cells, which are modified in the lab to better recognize and attack the cancer while resisting a protein that tu…

This early-phase study tests a new treatment for people with Hodgkin or non-Hodgkin lymphoma that has come back or not responded to standard therapy. Researchers take a patient's own immune cells (T cells), add a special receptor that targets the CD30 protein found on lymphoma ce…

This study tests a new ultrasound otoscope to better diagnose middle ear infections in children. About 300 kids scheduled for ear tube surgery will have their ears scanned with the device. The goal is to see if the ultrasound can tell the difference between infected and non-infec…

This study looks at whether mailing self-sampling kits for HPV testing can help more Asian and Asian American women get screened for cervical cancer. Many women find it hard to go to a clinic for a Pap test, so this approach offers a convenient at-home option. The study involves …

This study tests a program called 'Healthy Dads, Healthy Kids' adapted for Hispanic families. It aims to help fathers lose weight and increase their children's physical activity. About 187 fathers and their kids (ages 5-11) in the Houston area will take part. The program focuses …

This study planned to see if adding ear acupuncture during surgery to repair a broken lower leg could lower the amount of opioid painkillers patients needed afterward. It was designed for adults aged 18 to 64 having ankle surgery. However, the study was withdrawn before any parti…

This study planned to test whether giving patients ear acupuncture during wrist fracture surgery would lower their need for opioid painkillers afterward. It was designed for adults aged 18-64 having a specific type of wrist repair. However, the study was withdrawn before any part…

This study compares a new bipolar knife to a standard monopolar knife for removing colon growths through a scope. About 80 adults will take part to see which knife works faster and causes fewer side effects like bleeding or pain. The goal is to improve the surgery experience and …

This study compares two family-based behavioral treatments delivered via telehealth for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD). The goal is to see if these lower-intensity therapies can reduce symptoms as effectively as standard care. About 100 chi…

This study aims to help mothers of babies in intensive care cope with depression, anxiety, and stress while also providing resources for food, rent, and utilities. About 200 caregivers of infants up to 6 months old will receive emotional support and referrals to community service…

This study tests whether Invisalign clear aligners can safely straighten teeth in people with Osteogenesis Imperfecta (OI), a condition that makes bones brittle and dental work risky. About 57 participants aged 12 to 40 with mild to moderate dental misalignment will receive treat…

This study aimed to see if a synthetic cannabis drug (THC) could safely reduce long-term pelvic pain in women with endometriosis. It planned to give up to 75 women either THC or a placebo for 8 weeks and track changes in pain and side effects. However, the trial was withdrawn bef…

This study compares two different knives used during a procedure called POEM, which treats swallowing problems caused by tight esophagus muscles. The standard knife uses one type of electrical current, while the new knife uses a different type and may cause less pain after surger…

This study is for people with severe, hard-to-treat OCD. Researchers are testing an advanced brain stimulation system that can adapt to brain signals. The goal is to find reliable brain markers of OCD distress, which could lead to better treatments in the future. Only 2 participa…

This study tests whether a series of short educational videos can help parents of teens with anorexia feel more knowledgeable, confident, and less stressed. About 50 families will either receive standard care or standard care plus the videos. Researchers will check if parents fin…

This study aims to better understand the genetic causes of Goltz syndrome, a rare condition that affects the skin, skeleton, eyes, and other organs. Researchers collect blood samples from up to 84 participants and their parents to analyze DNA and identify mutations. The goal is t…

This study follows up on very low birth weight babies (under 1000 grams) who received either a standard or high-protein diet while in the NICU. Researchers want to see if the high-protein diet leads to better growth, body composition, and brain development when the children are 1…

This study looks at teeth misalignment and neck problems in people with moderate to severe osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will use scans of the teeth, jaw, and neck to measure these issues in 75 participants aged 10 a…

This study looks at how well noninvasive tests (like blood markers, Fibroscan, and MRI) can detect liver scarring in people with urea cycle disorders. About 62 participants aged 6 to 65 will be tested at five medical centers. The goal is to find better ways to monitor liver healt…

This study aims to find genetic changes that cause recurrent hydatidiform moles, a rare pregnancy condition where abnormal tissue grows instead of a healthy baby. Researchers will analyze DNA from up to 100 women with a personal or family history of these moles, as well as some r…

This study looks at how osteogenesis imperfecta (brittle bone disease) affects the heart and lungs. Researchers will measure lung function and use CT scans in 18 adults to find out why breathing problems are the leading cause of death in this condition. No new treatment is being …

This study follows about 51 premature infants (born before 37 weeks, weighing 2.75 pounds or less) who received donor human milk in the NICU. Researchers want to see how these babies grow and develop after they go home. The goal is to learn more about the long-term effects of an …

This study looks at whether chewing xylitol gum during pregnancy can change the bacteria in the mouth and vagina, reduce gum inflammation, and improve pregnancy outcomes. About 80 pregnant women in Malawi will chew the gum daily from before 20 weeks until delivery. Researchers wi…

This study looks at whether giving breast milk mouth care to newborns with gastroschisis (a rare abdominal wall defect) can help them tolerate feedings sooner and reduce infections. Researchers will compare babies who receive breast milk mouth care to those who get sterile water.…

This study explores whether measuring certain collagen peptides in urine can help doctors tell apart the many genetic types of osteogenesis imperfecta (OI), a rare condition that makes bones break easily. Researchers will compare urine samples from 25 people with different OI gen…

This study looks at whether a short home visitation program, delivered by non-nurse visitors, can help pregnant and postpartum women connect to community resources, feel more confident about their health, and reduce stress. About 450 women will take part, with half offered free h…

This early-phase study is testing a new type of deep brain stimulation (DBS) that automatically adjusts based on brain signals in people with severe, treatment-resistant OCD. Only 2 participants are enrolled to help researchers identify brain activity patterns linked to OCD distr…

This study looks at whether testing men for HPV antibodies or viral DNA in their blood can help find throat and anal cancers earlier. Researchers will follow 1,500 men over time to see how HPV infection relates to cancer risk. The goal is to develop better screening methods for t…

This study looks at whether giving supplements that boost glutathione, a natural antioxidant, can improve thinking and memory in older adults with mild cognitive impairment. Sixty participants will take either the active supplements or a placebo for 12 weeks, then stop for anothe…