Engineered immune cells take on Hard-to-Treat sarcoma

NCT ID NCT00902044

First seen Jan 27, 2026 · Last updated May 15, 2026 · Updated 18 times

Summary

This study tests a new treatment for people with advanced sarcoma, a type of cancer that has not responded to standard therapies. Researchers take a patient's own immune cells (T cells) and add a new gene to help them recognize and attack cancer cells that have a protein called HER2. Before receiving the modified cells, some patients get chemotherapy to help the cells work better. The main goals are to find a safe dose and see if the treatment can shrink tumors.

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Contacts and locations

Locations

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.