SARCOMA

This study is testing a drug called TURALIO (pexidartinib) in people aged 3 to 35 whose cancer has come back or not responded to standard treatments. The cancers include certain leukemias, solid tumors, and tumors linked to neurofibromatosis type 1. The goal is to find the safest…

This study tests whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) can help control advanced soft tissue sarcoma that has spread or cannot be removed by surgery. About 98 adults with this type of cancer will…

This study tests whether combining two drugs—ATRA and cemiplimab—can shrink or slow advanced leiomyosarcoma, a rare soft-tissue cancer. About 16 adults whose cancer worsened after standard chemotherapy will receive ATRA pills for 3 days before each cemiplimab infusion, then cemip…

This study tests a new oral drug called STC-15, either alone or combined with toripalimab, in people with advanced solid tumors or certain sarcomas (leiomyosarcoma and liposarcoma). The goal is to see if the treatment is safe and can shrink or control tumors. About 107 adults wit…

This early-phase study tests a new treatment called PeptiCRAd-1, a virus-based cancer vaccine, combined with the immunotherapy drug pembrolizumab. The goal is to see if this combination is safe and can boost the immune system to fight several types of solid tumors, including mela…

This study tests a new drug combination for people with advanced bone or soft tissue sarcoma that has stopped responding to standard treatment. The combo includes a safer form of chemotherapy (paclitaxel polymer micelles), another chemo drug (gemcitabine), and a targeted therapy …

This early-phase study tests a new drug called SLV-154 in about 70 people whose solid tumors (like head and neck, lung, breast, or ovarian cancer) have spread. The main goal is to find a safe dose and watch for side effects. Participants must have a confirmed diagnosis and be in …

This early-phase study tests whether giving specially engineered immune cells (HER2-CAR T cells) together with an immune checkpoint inhibitor (pembrolizumab or nivolumab) is safe and can help people with advanced sarcoma. About 25 participants will receive chemotherapy to prepare…

This study is testing whether giving a lower dose of the chemotherapy drug doxorubicin weekly, instead of the standard higher dose every three weeks, is effective and easier to tolerate for older patients (ages 65-100) with advanced soft tissue sarcoma. The main goal is to see if…

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if their cancer might respond to the drug. Participants receive the same dose every 3 weeks, and the study checks if the geneti…

This study tests a new drug called GI-101, either alone or with pembrolizumab or lenvatinib, in people with advanced solid tumors (cancers that have spread). The goal is to see if it is safe and works against the cancer. About 317 adults with certain cancers like lung, kidney, or…

This study tests a drug called zanidatamab in adults with certain advanced cancers (lung, endometrial, colorectal, head & neck, or sarcoma) that have a specific change in the HER2 gene. The goal is to see if the drug can shrink tumors. Participants receive the drug by IV every 3 …

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This study tests a new type of radiation therapy (SFRT) given before surgery for people with large soft tissue sarcoma (at least 5 cm) in the arm, leg, or trunk. The goal is to see if this approach can improve the chance of staying cancer-free for at least one year. About 22 adul…

This early-phase study is testing a new treatment called B7-H3 CAR T cells in children and young adults whose solid tumors (like neuroblastoma, sarcoma, or osteosarcoma) have come back or not responded to standard therapies. The treatment involves taking a patient's own immune ce…

This study tests whether a single-use negative pressure wound dressing (PICO14) can reduce wound complications after surgery for soft tissue sarcoma of the limbs in patients who had radiation therapy. About 48 adults will be randomly assigned to receive either the special dressin…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This early-phase study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatm…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This early-phase trial tests a new treatment for people with advanced solid tumors (sarcoma, lung cancer, or melanoma) that have not responded to first-line therapy. The treatment involves taking a patient's own immune cells, modifying them in the lab to better recognize and atta…

This early-phase study tests a new drug called OKN4395, alone or with an immunotherapy (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses and see if the drug can shrink tumors. About 166…

This early-phase trial tests a new drug, CRD3874-SI, which aims to activate the immune system to fight advanced solid tumors like sarcoma and Merkel cell carcinoma. Researchers will find the safest dose and check if it shrinks tumors. About 81 adults with cancers that have stoppe…

This study is for adults with soft tissue sarcoma who need radiation before surgery. It compares a standard 14-session radiation schedule to a shorter 5-session schedule. The goal is to see if the shorter course leads to similar wound healing and cancer control, while being more …

This study tests whether the drug nivolumab can be safely given after a half-matched bone marrow transplant to help prevent sarcomas from coming back. It includes children and young adults (ages 1 to 50) who have recently had this transplant and are at high risk of relapse. Resea…

This study tests whether using a fluorescent dye called indocyanine green (ICG) during surgery helps surgeons see and remove sarcoma tumors more completely. About 90 adults with intermediate-to-high grade sarcoma of the trunk or limbs will take part. The goal is to reduce the num…

This study tests a new drug called KIVU-107 in people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The main goals are to find the safest dose and check fo…

This study tests whether a special type of radiation called GRID, given before standard radiation and surgery, is safe and effective for people with soft tissue sarcoma in their arms or legs. The goal is to improve tumor removal and reduce the chance of the cancer coming back, wi…

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This study tests a new drug called PEEL-224 combined with two standard chemotherapy drugs (vincristine and temozolomide) in adolescents and young adults whose sarcomas have come back or not responded to treatment. The goal is to find the safest dose and see if the combination shr…

This study tests a procedure called TACE (chemoembolization) for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor, then block that artery with tiny beads. This traps t…

This program provides the experimental drug selinexor to people with multiple myeloma, lymphoma, sarcoma, or other cancers who have run out of standard treatments and cannot join a clinical trial. The goal is to offer a potential treatment option when nothing else is left. Patien…

This study tests whether adding the immunotherapy drug pembrolizumab to chemotherapy drugs (melphalan and dactinomycin) delivered directly to the affected arm or leg can safely delay cancer growth. About 30 people with advanced or spreading sarcoma in a limb will take part. The g…

This study tests an experimental oral drug called ABSK043 in about 20 people with advanced angiogenic sarcomas (intimal sarcoma, head/neck angiosarcoma, or EHE). The drug blocks a protein called PD-L1 to help the immune system attack cancer cells. The main goal is to see if the d…

This study tests a new treatment called T3011, given as a shot directly into tumors, for people with advanced or metastatic solid tumors (like melanoma or lung cancer). It is for adults whose cancer has worsened after standard treatments. The goal is to see if T3011 is safe and c…

This study tests whether pembrolizumab, a drug that helps the immune system attack cancer, can shrink or control ultra-rare sarcomas. About 32 adults with specific rare sarcoma types will receive the drug. The goal is to see if it works with mild side effects.

This early-stage study tests whether a new treatment combining radiation and specially engineered immune cells (B7-H3-CAR T cells) is safe for children and young adults up to age 21 with sarcomas that have returned or not responded to standard therapy. The treatment aims to help …

This study tests a new treatment that delivers a powerful, short-range radioactive particle directly to cancer cells that have a protein called FAP on their surface. The therapy is given in two steps: first a low-dose imaging version to see if the tumor takes up the drug, then a …

This study is testing whether a new PET imaging tracer called [18F]FAPI-74 can find tumors as well as or better than the standard tracer in adults with certain cancers (like pancreatic, ovarian, or lung cancer). Participants will get both types of scans to compare how many tumors…

This study is testing a new radioactive tracer that targets a protein called LRRC15, found on many cancers like pancreatic, breast, lung, and brain tumors. The tracer is used with PET scans to see if it can better detect and stage these cancers compared to standard scans. The stu…

This study tests whether a fluorescent dye called indocyanine green (ICG) can help surgeons see if any tumor remains after removing a sarcoma. About 110 adults with bone or soft tissue sarcoma will receive the dye before surgery, and a special camera will check for leftover cance…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps immune cells attack…

This study tests a smartphone app that connects young adults (ages 18-40) who have finished treatment for certain cancers (lymphoma, breast, testicular, or sarcoma) with trained peer navigators. The goal is to see if this digital support program is feasible and helps participants…

This study is testing a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages participants to stay engaged with their follow-up medical care. Abo…

This study looks at whether giving sarcoma patients early access to mental healthcare before and after surgery can help reduce depression and anxiety. About 60 adults with bone or soft tissue sarcoma will be randomly assigned to get either early psychiatric support or usual care.…

This study looks at whether a structured exercise program can help children, teens, and young adults (ages 12-39) with sarcoma complete more of their planned chemotherapy. Participants will either exercise or receive standard care. The goal is to see if exercise is feasible and h…

This study tests whether a personalized pre-surgery program of physical therapy, exercise, and nutrition can help people with bone or soft-tissue sarcoma of the arm or leg recover better after surgery. About 53 participants will follow the program before their operation and be mo…

This study collects extra blood, urine, and tumor samples from children and adults with childhood cancers (like leukemia or sarcoma) to create a large tissue repository. Researchers will use these samples to study the genetic and molecular makeup of these cancers. The goal is to …

This study follows 180 adults with gastrointestinal or sarcoma cancers who are receiving standard treatments like radiation. Researchers will monitor how long patients live without cancer returning and track any side effects. The goal is to learn how newer treatments are affectin…

This study is building a huge national database of up to 150,000 sarcoma patients in France. Researchers will collect medical records, tumor samples, and treatment information to learn more about how sarcomas are treated and what affects patient outcomes. No new treatments or dru…

This study aims to create immune organoids—tiny, lab-grown models of the immune system—from the cells of children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will use these organoids to study how tumors interact with immune cells. The…

This study watches how children and their caregivers recover after major cancer surgery. About 40 kids and their parents will wear smartwatches, answer surveys, and give extra blood samples for up to a year. The goal is to find patterns that show how well someone is bouncing back…

This study analyzes tumor samples from 12,000 cancer patients to find gene changes (mutations). The goal is to match each person with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to improve future treatme…

This study aims to see if a 3-month daily survey method is practical for understanding chronic pain and opioid use in adolescent and young adult sarcoma survivors. About 40 participants aged 12-24 at diagnosis, now in survivorship care with meaningful pain, will complete brief da…

This study looks at tissue and imaging data from 800 people with high-risk soft tissue sarcoma to find ways to personalize chemotherapy. Participants either have surgery alone or chemo before surgery. The goal is to build a tumor atlas and a tool to predict who benefits from chem…

This study aims to understand the quality of life, medical care satisfaction, and unmet needs of people who have lived with sarcoma for 5 years or more. Researchers will survey 1,600 survivors and interview up to 60 participants in Germany. The goal is to learn what challenges su…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to help researchers develop and improve blood tests that can detect many types of cancer early. Participants provide samples that are stored and later used to test new diagnostic methods.…

This study aims to see if a blood test can detect tumor DNA (ctDNA) in people with soft tissue sarcoma. Currently, doctors need to take a piece of the tumor (biopsy) to diagnose and monitor the disease, which can be risky and difficult. Researchers will collect blood samples from…

This study follows 2100 people of any age who have had sarcoma, a rare cancer, to learn how the disease and its treatments affect their health over time. Researchers will review medical records and ask participants about their well-being, lifestyle, and background. The goal is to…

This study looks at whether watching a video before genetic testing helps people with certain cancers understand their hereditary risk better. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Researchers…

This study tests whether a smartwatch and artificial intelligence can detect early signs of heart problems in people who have had lymphoma or sarcoma. About 250 participants will use a mobile device to record their heart's electrical activity, which an AI will analyze to find hid…

This study aims to see if a smartphone app can help track recovery in 800 sarcoma patients after surgery. Participants will fill out health questionnaires and let the app monitor their steps, stairs, and walking patterns for one year. The goal is to better understand how patients…

This study tests whether watching short educational videos before a first appointment with a sarcoma specialist helps patients and caregivers learn more about their disease and treatment options. About 100 adults with advanced sarcoma (or their caregivers) who have not yet had tr…

This study tests a checklist tool that helps sarcoma patients plan for their future mobility needs, such as getting around the house or dressing. About 20 patients and their caregivers will use the tool and give feedback on how easy and helpful it is. The goal is to see if this t…

This study looks at whether a safe green dye, called ICG, can help surgeons see if cancer has spread to nearby lymph nodes in children with solid tumors. About 10 children under 18 who need lymph node surgery will get the dye injected during their operation. The goal is to see if…

This study is testing a blood test called liquid biopsy to see if it can find bits of tumor DNA in people with sarcoma (a type of bone or soft tissue cancer). Researchers will collect blood samples from 300 participants before, during, and after treatment to see how well the test…

This study creates a registry for up to 5,000 children and young adults (up to age 26) receiving radiation therapy for brain tumors or sarcoma. Researchers will collect detailed radiation dose information and follow participants over time to understand long-term survival, side ef…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study is gathering tumor, blood, and plasma samples from over 1,000 people with certain cancers (ovarian, triple-negative breast, head and neck, cervical, vulva, and sarcoma). The goal is to find new biomarkers that link a tumor's genetic changes and the body's immune respon…

This study is a large registry that will collect information from up to 9,000 people in Germany who have been diagnosed with sarcoma or carcinosarcoma. The goal is to gather data on how often different types of sarcoma occur, their outcomes, and how they are treated. No new treat…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…