SARCOMA

This phase 2 trial tests whether adding a drug called liposomal transcrocetin (L-TC) to short-course radiation before surgery can kill more cancer cells in people with soft-tissue sarcoma. About 42 adults with localized or locally advanced sarcoma will be randomly assigned to rec…

This study tests a new medicine called Risvutatug Rezetecan (Ris-Rez) in adolescents and adults with advanced bone or soft tissue sarcomas that have come back or spread and can't be removed by surgery. The goal is to see if the drug can slow cancer growth and how safe it is. Abou…

This study tests whether leaving the needle biopsy track in place during sarcoma surgery is as safe as removing it. The goal is to see if avoiding extra tissue removal can lower complications without increasing the chance of the cancer coming back. About 3,300 people with sarcoma…

This early-phase trial tests a new radioactive drug, 177Lu-INN805, in 10 people with advanced solid tumors (like head & neck, lung, breast, or sarcoma) that haven't responded to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers wi…

This early-phase trial tests a new type of immunotherapy called CD70 CAR T cells in people with lymphoma, myeloma, and certain solid tumors (like kidney cancer and sarcomas) that have come back or not responded to standard treatments. The immune cells are modified in the lab to r…

This early-phase trial tests a combination of three drugs—selumetinib, ZEN-3694, and durvalumab—in people with advanced sarcomas, including malignant peripheral nerve sheath tumors (MPNST) linked to NF1. The study first checks safety and dosing, then looks at whether the treatmen…

This early-phase trial tests a new drug called BOLD-100 combined with standard chemotherapy (doxorubicin) in 32 people with advanced soft tissue sarcomas that cannot be removed by surgery or have spread. The goal is to find the safest dose and see if the combination can shrink tu…

This study tests whether a special MRI sequence, called 'pseudo-scanner,' can accurately map bone tumors and guide surgery, potentially replacing CT scans. About 122 people with bone sarcoma who need surgery will participate. If successful, this approach could reduce patients' ex…

This study tests whether a personalized exercise program can improve physical function and quality of life in adolescents and young adults who have survived sarcoma. Participants first complete a triage tool to assess their needs, then receive a 12-week exercise plan that may inc…

This study tests whether a single hypnosis session during chemotherapy can reduce anxiety and other side effects like nausea in young people with cancer. It includes 70 participants aged 15-49 with sarcoma, germ cell tumors, or breast cancer. Researchers will compare anxiety leve…

This study tests whether adding acupuncture to standard care can lower the risk of hospital stays for a serious chemo side effect called febrile neutropenia (fever with low white blood cells). About 60 adults with sarcoma receiving doxorubicin chemotherapy will be randomly assign…

This study is testing a new AI chatbot designed to answer questions from people with sarcoma, a type of cancer. The chatbot will be available 24/7 by voice or text for one month. Researchers want to see if using the chatbot helps patients feel more satisfied with the information …

This study will test whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with various cancers who are starting immunotherapy will take a low-dose cocktail of 7 common drugs. Researchers will measure drug lev…

This study is testing a mobile app called my.naviGATE for teens and young adults (ages 15-24) who have finished cancer treatment. The app provides personalized education, peer support, and tracks how patients are doing. Researchers want to see if the app helps patients feel more …

This very small study will test whether it is practical to add three extra MRI scans during standard radiation treatment for soft tissue sarcoma. Only 5 adults will take part. The goal is simply to see if the extra scans can be completed, not to change treatment or improve outcom…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…