SARCOMA

This study tests a combination of two drugs, NKTR-214 and nivolumab, in people with advanced sarcoma that has spread. The goal is to see if the drugs can shrink tumors or stop them from growing. About 88 participants aged 12 and older will take part, and the main measure is how m…

This study tests a combination of two treatments—heat-based tumor destruction (thermal ablation) and precise high-dose radiation (stereotactic radiosurgery)—for people whose cancer has spread to the spine and is pressing on the spinal cord. The goal is to control the tumor and pr…

This study looks at a small, permanent radiation patch called CivaSheet that is placed inside the body during surgery to treat sarcoma tumors in the belly, pelvis, or trunk. The goal is to see if it is safe and how well it controls the cancer over 5 years. About 100 people who ca…

This early-phase trial tests a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and ziv-aflibercept (which cuts off blood supply to tumors)—in people with advanced solid tumors that have spread. The main goal is to find the safes…

This study tests whether combining a cancer-killing virus (T-VEC) with an immunotherapy drug (pembrolizumab) can shrink tumors in people with advanced sarcoma that cannot be removed by surgery. About 41 adults with certain sarcoma types will receive both drugs. The main goal is t…

This study tests a new treatment for people with advanced sarcoma, a type of cancer that has not responded to standard therapies. Researchers take a patient's own immune cells (T cells) and add a new gene to help them recognize and attack cancer cells that have a protein called H…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This study compares two common blood thinners, aspirin and low molecular weight heparin (LMWH), to prevent dangerous blood clots after orthopedic surgery for cancer. About 2,868 adults having surgery on the pelvis or leg for bone metastases or sarcoma will be enrolled. The goal i…

This study is for people newly diagnosed with a rare cancer called DSRCT. It adds three drugs (irinotecan, temozolomide, and bevacizumab) to the usual chemotherapy to see if the combination is safe and tolerable. About 15 participants aged 1 to 30 will take part. The goal is to u…

This study tests a combination of two drugs, epacadostat and pembrolizumab, in adults with advanced sarcoma that has spread or cannot be removed by surgery. The goal is to see if the combo can shrink tumors or slow the disease. Participants must have tried at least one prior trea…

This study tests whether combining two drugs (etrumadenant and zimberelimab) can shrink or slow advanced dedifferentiated liposarcoma, a rare soft tissue cancer. About 16 adults whose cancer has returned, spread, or cannot be removed by surgery will receive the treatment. The mai…

This early-phase study tested the safety and best dose of adding bevacizumab to standard chemotherapy and radiation for people with soft tissue sarcoma that can be removed by surgery. The goal is to see if this combination can lower the chance of the cancer returning. The study i…

This study tests an inhaled form of a protein called interleukin-2 (IL-2) to treat cancers that have spread to the lungs, such as melanoma, kidney cancer, and sarcoma. The goal is to find the safest dose and see if it can shrink tumors. About 70 adults with advanced cancer and lu…

This study tests a combination of two chemotherapy drugs, irinotecan and carboplatin, as the first treatment for people newly diagnosed with intermediate- or high-risk rhabdomyosarcoma, a type of muscle cancer. The goal is to see if this drug pair can shrink tumors and improve ou…

This study tests two immunotherapy drugs, nivolumab and azacitidine, in people whose osteosarcoma (a type of bone cancer) has come back and can be removed with surgery. The goal is to see if these drugs are safe and help keep the cancer from returning after surgery. About 21 adul…

This study tests an experimental drug called HFB200301, alone or with another drug (tislelizumab), in adults with advanced solid tumors like stomach, kidney, or lung cancer. The main goal is to find safe doses and check for side effects. About 72 people will take part, and the st…

This pilot study at Duke University tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve wound healing in 20 adults with soft tissue sarcoma who had radiation and surgery. Participants are randomly assigned to receive either the oxy…

This study compares two ways of giving high-dose radiation to people with cancer that has spread to bones, spine, soft tissue, or lymph nodes. One schedule gives the radiation in one day, the other over three days. The goal is to see which schedule better controls the cancer in t…

This early-phase study tests a new type of proton therapy called Pro-GRID for people with large tumors (over 7 cm) that are hard to treat. The goal is to see if the treatment is safe and can be delivered successfully. The study involves 11 adults with sarcoma or melanoma, and foc…

This study creates a large registry to collect information from nearly 58,000 children diagnosed with cancer or similar conditions in the U.S. and Canada. The goal is to help researchers study patterns, causes, and characteristics of childhood cancers. Parents provide details abo…

This study collects leftover tissue, blood, and other body fluids from 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples to learn more about what causes these cancers and how to better prevent, …

This study searches for brand-new gene changes that appear in a person with cancer but not in their parents. By comparing cancer patients, their healthy parents, and other family members, researchers hope to uncover genetic clues that raise cancer risk. The goal is to better iden…

This study looks at whether a special PET scan combined with MRI can measure low oxygen levels (hypoxia) in soft tissue sarcoma tumors. About 70 adults with high-risk sarcoma will receive an injection of a radioactive tracer called FAZA before their standard treatment. The goal i…

This study looks back at the medical records of 250 sarcoma patients who received immunotherapy at Memorial Sloan Kettering Cancer Center. The goal is to gather information and better understand how well these treatments work. No new treatments are given; the study simply collect…

This study uses a radioactive antibody (124I-Hu3F8) and PET/CT scans to see how the antibody moves through the body and reaches tumors. Seven people with melanoma, neuroblastoma, or sarcoma will receive one injection and have multiple scans over several days. The goal is to under…

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to check their genetic markers and tumor features. The goal is to find who might qualify for future experimental T-cell therapies that target specific cancer antigens. …