SARCOMA

This study is testing a specific combination of chemotherapy drugs (irinotecan and carboplatin) as the first treatment for children and young adults newly diagnosed with intermediate- or high-risk rhabdomyosarcoma, a type of muscle cancer. The goal is to see how well the tumor re…

This study is testing whether two immunotherapy drugs, nivolumab alone or combined with azacitidine, are safe and can help prevent cancer from coming back in patients with recurrent osteosarcoma (a type of bone cancer) that has spread to the lungs but can be surgically removed. P…

This early-stage study is testing the safety of a three-part treatment given before surgery for soft tissue sarcoma. The treatment combines a targeted drug (bevacizumab), a chemotherapy (doxorubicin), and radiation therapy. The main goal is to find the highest safe dose of bevaci…

This early-stage study is testing a new proton radiation technique called Pro-GRID for patients with large, difficult-to-treat tumors. The method delivers radiation in a grid pattern to try to shrink tumors while sparing healthy tissue. Researchers aim to see if this approach is …

This study is testing whether using two treatments together works better than one to control cancer that has spread to the spine and is at risk of pressing on the spinal cord. Doctors combine a heat treatment (thermal ablation) that destroys tumor cells with a very precise, high-…

This study is testing whether combining two immunotherapy drugs, NKTR-214 and nivolumab, can help control advanced sarcoma. It is for patients aged 12 and older whose cancer has progressed after at least one prior treatment. The main goal is to see how many patients' tumors shrin…

This study aims to find the best way to give high-dose radiation to control cancer that has spread to bones, the spine, soft tissue, or lymph nodes. It compares giving all the radiation in one day versus spreading it over three days, using precise imaging to target the tumor and …

This early-stage study is testing whether adding three new drugs (irinotecan, temozolomide, and bevacizumab) to the standard high-dose chemotherapy can help control a rare and aggressive cancer called Desmoplastic Small Round Cell Tumor (DSRCT). The main goal is to see if this co…

This is an early-stage study to find a safe dose of a new immunotherapy drug called HFB200301. It is being tested alone and in combination with an existing drug (tislelizumab) in adults with advanced solid tumors who have already tried other treatments. The main goal is to see ho…

This study is testing whether combining two immunotherapy drugs can help control advanced sarcoma, a rare and aggressive cancer. The trial is for adults with certain types of sarcoma that have spread or cannot be surgically removed, and who have typically tried at least one other…

This early-stage study is testing a new combination of two existing cancer drugs, pembrolizumab and ziv-aflibercept, in patients with advanced solid tumors. The main goal is to find the safest and most effective dose of the combination. Researchers will also look for early signs …

This study is testing whether a combination of two immunotherapy drugs, etrumadenant and zimberelimab, can help control advanced dedifferentiated liposarcoma. It is for adults whose cancer has spread, returned after prior treatment, or cannot be removed by surgery. The main goal …

This study is testing a new treatment for advanced sarcoma, a type of cancer. Doctors take a patient's own immune cells (T-cells), genetically modify them in a lab to recognize and attack cancer cells, and then infuse them back into the patient. The main goals are to find the saf…

This early-stage study is testing an inhaled form of an immune-boosting drug (aldesleukin) for people whose cancer has spread to their lungs. The main goals are to find a safe dose and see if the treatment causes side effects. Researchers also want to learn if inhaling the drug d…

This is an early safety study testing a new cancer vaccine called PeptiCRAd-1, given alongside the immunotherapy drug pembrolizumab. It aims to see if this combination is safe and can activate the immune system to fight cancer in patients with advanced solid tumors that have stop…

This study aims to find the best way to prevent dangerous blood clots in patients having surgery for bone or soft tissue cancer in the leg or pelvis. It will compare two common prevention methods: daily aspirin pills versus daily blood-thinner injections (LMWH). Researchers want …

This study is testing a digital tool called an 'oncology dashboard' that shows sarcoma patients and their doctors visual information about how their cancer is responding to treatment. Researchers want to see if using this dashboard helps patients better understand their disease a…

This study aims to understand how low oxygen levels inside sarcoma tumors affect treatment success. Researchers will use a special PET/MRI scan with an experimental tracer called FAZA to measure tumor oxygen in about 70 patients before they start treatment. The goal is to gather …

This study aims to learn more about how well immunotherapy works for people with sarcoma. Researchers will collect information from the medical records of about 250 patients who have received certain immunotherapy treatments at Memorial Sloan Kettering Cancer Center. The goal is …

This study created a large registry to collect information about children with cancer across the United States and Canada. Researchers ask parents to share details about their child's diagnosis and family background to build a comprehensive database. The goal is to help scientist…

This study is screening cancer patients to collect genetic information from their tumors and saliva. Researchers will analyze this data to identify patients who might qualify for future clinical trials testing new cellular therapies. No treatment is provided in this study—it's pu…

This study collects leftover tissue and blood samples from patients with various cancers to help researchers understand these diseases better. The samples come from patients already having medical procedures, using only material that would otherwise be discarded. Researchers will…

This study aims to understand how a lab-made antibody called Hu3F8 moves through the body and reaches tumors in patients with certain advanced cancers. Researchers will use a special PET scan to track a tiny radioactive tag attached to the antibody. The goal is to gather informat…

This study aims to discover new types of inherited gene changes that might explain why some people develop cancer. Researchers are studying cancer patients along with their unaffected parents to look for gene differences that appear in the child but not the parents. The goal is t…