SARCOMA

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This phase 2 trial tests a combination of two drugs—chidamide and toripalimab—in people with advanced soft-tissue sarcoma that has not responded to standard treatments. Chidamide is a pill that may help the immune system recognize cancer cells, while toripalimab is an immunothera…

This early-phase trial tested whether giving activated natural killer (NK) cells, with or without a protein called rhIL15, is safe and feasible for children and young adults with solid tumors that didn't respond to other treatments. Sixteen participants received chemotherapy to l…

This early-phase study tested a new radioactive drug called 177Lu-CTR-FAPI in 12 people with advanced solid tumors (breast cancer, sarcoma, or thyroid cancer) that had spread and no longer responded to standard treatments. The main goals were to see if the drug is safe and how it…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This study tested whether adding the immunotherapy drug durvalumab to standard chemotherapy (doxorubicin) could help people with advanced soft tissue sarcoma that has spread or come back. The trial included 44 adults whose cancer could be measured and who were healthy enough for …

This study tested the drug regorafenib in 219 adults with soft tissue sarcoma that had spread and was no longer responding to standard chemotherapy. Participants were randomly assigned to receive either regorafenib or a placebo. The main goal was to see if the drug could delay ca…

This early-phase trial tested a treatment that uses a patient's own immune cells (called TILs) to fight soft tissue sarcoma. Nine young adults received chemotherapy to prepare their bodies, then an infusion of their own TILs plus high-dose IL-2 to boost the immune response. The m…

This early-phase study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine) is safe for people with two rare types of soft tissue sarcoma (leiomyosarcoma and undifferentiated pleomorphic sarcoma). Twenty-five adults with advanced or in…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and cyclophosphamide (a chemotherapy)—in 129 people with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the combination could shrink tumors or stop them fro…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested whether artificial intelligence (AI) can help doctors tell the difference between cancerous and non-cancerous soft tissue lumps using MRI scans. 186 patients with soft tissue masses had extra MRI images taken. The AI was trained to identify which lumps were sarc…

This study tested a mobile app called WeCanManage designed to help cancer survivors with disabilities manage long-term effects of their illness and treatment. Twenty adults who had breast cancer, head and neck cancer, or sarcoma used the app and reported on how helpful and easy i…

This study tested a simple checklist tool to help people with sarcoma think about and plan for their future mobility needs, like getting around the house or dressing. 27 patients and their caregivers used the checklist after limb-saving or amputation surgery. The goal was to see …

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This completed study with 654 sarcoma patients aims to create a better way to measure health-related quality of life. Current questionnaires miss key issues unique to sarcoma, like specific side effects and functional problems. By interviewing patients and healthcare professional…

This completed study enrolled 84 people with brain tumors, meningioma, or high-grade sarcoma who received proton beam therapy. Researchers analyzed tumor and blood samples to find biomarkers that might predict how well the cancer responds to treatment. The goal is to eventually h…

This study reviewed medical records of 207 adults who died from sarcoma to understand how they were cared for by palliative teams. Researchers looked at when patients first saw a palliative care doctor, were admitted to a palliative care unit, or received advice from a mobile pal…

This study tested a tool called an oncology dashboard that shows a patient's cancer treatment information to them, their doctor, and their radiologist. The goal was to see if it helps patients understand their disease better and makes care more efficient. The study included 92 pe…

This study looks at healthy skin tissue from 58 people with sarcoma to understand how aging changes cells and may increase cancer risk. Researchers compare skin from younger adults (18-40) and older adults (55+) to find markers of aging. The goal is to learn why certain skin canc…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This study looked at whether offering genetic counseling by phone or video could help more childhood cancer survivors get genetic testing. About 391 survivors took part, comparing remote counseling to usual care. The goal was to see if remote services increase testing uptake and …

This completed trial tested an interactive survivorship program for adolescent and young adult cancer survivors. The program included a mobile app, telehealth support, and printed materials to help survivors access healthcare resources, improve self-management skills, and reduce …

This study looked at 98 adults with cancers like melanoma and lung cancer who were starting immunotherapy. Researchers measured inflammatory markers in their blood to understand how the body reacts to these drugs. The goal was to find ways to better manage side effects from treat…

Researchers used machine learning to analyze electronic health records from 700 patients with osteosarcoma or Ewing's sarcoma. The goal was to find patterns in survival and other outcomes. No new treatment was tested; instead, the study aimed to learn from existing data to potent…

This study looked back at medical records of over 2,100 patients with metastatic soft tissue sarcoma treated in France between 1990 and 2013. Researchers analyzed which treatments patients received, including chemotherapy and local therapies, and how long they lived. The goal is …