SARCOMA

This study tested a new drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, or breast cancer) that had stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors. The study was completed, but res…

This early-phase study tested a combination of two drugs—pembrolizumab (an immunotherapy) and gemcitabine (a chemotherapy)—in 25 people with rare soft tissue sarcomas (leiomyosarcoma or undifferentiated pleomorphic sarcoma) that had spread or couldn't be removed. The main goal wa…

This study tested a combination of the immunotherapy drug durvalumab with standard chemotherapy (doxorubicin) in 44 people with advanced soft tissue sarcoma that had spread or come back. The goal was to see if adding durvalumab could improve outcomes for this aggressive cancer, w…

This study tested a combination of two drugs (MK3475 and cyclophosphamide) in 129 people with advanced sarcomas that could not be removed by surgery or had spread. The goal was to see if the treatment could shrink tumors or stop them from growing for at least 6 months. The trial …

This early-phase trial tested a treatment that uses a patient's own immune cells (called TILs) to fight soft tissue sarcoma. Nine young adults received chemotherapy to lower their immune system, then an infusion of their own tumor-fighting cells plus high-dose IL-2. The main goal…

This early-phase study tested whether immune cells called natural killer (NK) cells, taken from the patient's own blood and boosted in a lab, could be safely given back to children and young adults with solid tumors that didn't respond to standard treatments. Sixteen participants…

This study tested the drug regorafenib in 219 people with soft tissue sarcoma that had spread and was no longer responding to standard chemotherapy. Participants were randomly assigned to receive either regorafenib or a placebo. The goal was to see if the drug could slow cancer g…

This study tested whether artificial intelligence (AI) can help doctors tell if a soft tissue lump is cancerous (sarcoma) or harmless using MRI scans. 186 patients had extra MRI images taken, and AI algorithms were trained to identify cancer and its grade. The goal is to make dia…

This study tested a mobile app called WeCanManage designed to help cancer survivors who have disabilities manage long-term effects of their illness and treatment. Twenty adults who had breast cancer, head and neck cancer, or sarcoma used the app and reported on their symptoms and…

This study involved 654 adults with sarcoma to understand what matters most to them regarding their quality of life. Researchers interviewed patients and healthcare professionals to identify key issues not captured by existing questionnaires. The goal is to create a more accurate…

This study looked at healthy skin tissue from 58 adults in two age groups (18-40 and 55+) to understand why cancer risk rises with age. Researchers checked for signs of cell aging and DNA damage in skin cells. The goal was to learn more about the aging process, not to test a trea…

This study tested a program designed to help adolescent and young adult cancer survivors (ages 15-39) find and use healthcare resources after treatment. The goal was to improve their health knowledge, self-care skills, and support, and to reduce cancer-related distress. 549 survi…

This study tested a tool called an oncology dashboard that shows key information about a patient's cancer treatment to the patient, their doctor, and radiologist. The goal was to see if it helps patients understand their disease and helps the medical team work more efficiently. T…

This study analyzed tumor and blood samples from 84 patients with brain cancer, meningioma, or sarcoma to find biomarkers that predict how well proton beam therapy works. The goal is to identify genetic or immune markers linked to tumor shrinkage six months after treatment. This …

This study looked at the medical records of 700 people diagnosed with osteosarcoma or Ewing's sarcoma between 2003 and 2012. Researchers used computer programs and machine learning to find patterns in the data, especially around survival. No new treatments were given or tested.

This study looked at how the body's immune system reacts during cancer treatment with drugs called immune checkpoint inhibitors. Researchers measured inflammatory proteins in the blood of 98 adults with cancers like melanoma and lung cancer. The goal was to find patterns that cou…

This study looked at over 2,000 patients with advanced soft tissue sarcoma to see how they were treated in everyday medical practice, not just in controlled trials. Researchers analyzed which treatments patients received, how long they worked, and overall survival. The goal is to…

This study looked back at medical records of 207 adults who died from sarcoma to understand how they were cared for by palliative teams. Researchers tracked things like hospital stays in a palliative care unit, visits with a palliative doctor, and whether chemotherapy was given i…